Mickael PLOQUIN @mickp17000.bsky.social · 05/10/2025event.on24.com/wcc/r/507189...event.on24.comUltrasensitive MRD Detection with WGS ppmSeq: An Expert Panel Discussion on the Clinical and Global Impact of a Scalable MRD SolutionTuesday, October 07, 2025 at 2:00 PM Eastern Daylight Time. 021
Mickael PLOQUIN @mickp17000.bsky.social · 04/04/2025#specificity #GOML www.biorxiv.org/content/10.1... 060
Reposted by Mickael PLOQUINVizgen @vizgen.bsky.social · 30/01/2025🌟 Transforming #SpatialGenomics Research! Vizgen's #MERFISH technology makes groundbreaking discoveries in neuroscience, oncology, & more accessible to researchers worldwide. With 310+ publications (161 peer-reviewed), its global impact is undeniable. Explore: hubs.ly/Q034jjc80 031
Mickael PLOQUIN @mickp17000.bsky.social · 10/02/2025Sign and share www.change.org/p/petition-t...change.orgSign the PetitionPetition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068) 020
Reposted by Mickael PLOQUINVizgen @vizgen.bsky.social · 10/02/2025🔬 Expanding the Limits of Discovery with MERSCOPE Ultra™ 🔬 With an expansive 3 cm² imaging area, easily image normal & diseased tissues, multistage embryos, or serial tissue sections in a single run. Eliminate batch effects & experimental variation! 🔗 vizgen.com/merscope-ult... 042
Reposted by Mickael PLOQUINVizgen @vizgen.bsky.social · 07/02/2025Welcome Portrai Inc, our first Certified Service Provider in APAC! 🌏 Portrai pioneers large-scale spatial transcriptomics and now brings #MERSCOPE Ultra™ expertise to researchers—delivering high-resolution, high-throughput spatial insights at scale. 🔗 vizgen.com/certified-se... 032
Mickael PLOQUIN @mickp17000.bsky.social · 04/02/2025genomeweb.comUS Patent Review Panel Invalidates 10x Genomics' Patent Claims After Parse Biosciences ChallengeParse Biosciences, which has now triggered invalidation of three 10x Genomics patents in response to being sued for infringement, said it was a "significant legal victory." 010
Reposted by Mickael PLOQUINVizgen @vizgen.bsky.social · 16/01/2025🚨 Customer Spotlight: MERFISH 2.0! 💡 MERFISH 2.0 is revolutionizing #SpatialTranscriptomics, delivering exceptional data even from challenging #PDAC samples with suboptimal RNA quality. Marco Genua from Fondazione Telethon shares his success! 👉 Learn more: info.vizgen.com/merfish2.0 041
Reposted by Mickael PLOQUINEarlham Institute @earlhaminst.bsky.social · 07/01/2025ICYMI, our first preprint of 2025 is out, showcasing our first exploration of #SpatialTranscriptomics in plants using @vizgen.bsky.social #MERSCOPE. A great collab with @katielong.bsky.social and @cristobaluauy.bsky.social at JIC, and Ashleigh Lister and the #SingleCell team at Earlham Institute. 0154
Reposted by Mickael PLOQUINCristobal Uauy @cristobaluauy.bsky.social · 07/01/20251/10 We are thrilled to share our preprint on spatial transcriptomics in wheat spikes led by the amazing @katielong.bsky.social and Ashleigh Lister. We resolved expression of 200 genes to cellular resolution. Pre-print👉 tinyurl.com/c7t3kncf., @johninnescentre.bsky.social @earlhaminst.bsky.social 514767
Reposted by Mickael PLOQUINSanderson Center for Optical Experimentation @scope-umasschan.bsky.social · 03/01/2025The instruments at the SCOPE @umasschan.bsky.social are happy to welcome a new piece of equipment. The SCOPE staff is also quite excited about the new #MerscopeUltra. Contact us for more information if Merfish will help expand your research program. @vizgen.bsky.social #micrscopy #newtoys #dearsanta 071
Reposted by Mickael PLOQUINMickael PLOQUIN @mickp17000.bsky.social · 02/01/2025Molecular Cartography of the Human and MouseDown Syndrome Brain www.researchsquare.com/article/rs-5... 051
Mickael PLOQUIN @mickp17000.bsky.social · 02/01/2025Molecular Cartography of the Human and MouseDown Syndrome Brain www.researchsquare.com/article/rs-5... 051
Reposted by Mickael PLOQUINTatsuya Nobori @tatsuyanobori.bsky.social · 23/12/2024Spatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular Resolution www.biorxiv.org/content/10.1...biorxiv.orgSpatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular ResolutionThe diversity of plant inflorescence architectures is specified by gene expression patterns. In wheat ( Triticum aestivum ), the lanceolate-shaped inflorescence (spike) is defined by rudimentary spike... 0116
Reposted by Mickael PLOQUINEarlham Institute @earlhaminst.bsky.social · 02/01/2025We're excited to start 2025 with this preprint from a great collaboration between the Earlham Institute's #singlecell team and the Uauy Group at the @johninnescentre.bsky.social. 👏 #Spatial #Genomicsbiorxiv.orgSpatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular ResolutionThe diversity of plant inflorescence architectures is specified by gene expression patterns. In wheat ( Triticum aestivum ), the lanceolate-shaped inflorescence (spike) is defined by rudimentary spike... 194
Reposted by Mickael PLOQUINWaggoner Lab @labwaggoner.bsky.social · 30/12/2024Mature cDC1 establish and maintain functional tertiary lymphoid structures within tumor lesions doi.org/10.1101/2024... @miriammerad.bsky.social 064
Reposted by Mickael PLOQUINMickael PLOQUIN @mickp17000.bsky.social · 30/12/2024www.biorxiv.org/content/10.1... Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer 021
Mickael PLOQUIN @mickp17000.bsky.social · 30/12/2024www.biorxiv.org/content/10.1... Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer 021
Reposted by Mickael PLOQUINMike Galsworthy @mikegalsworthy.bsky.social · 25/12/2024Merry Christmas! Be of good cheer - it looks like Iceland is going to join the EU. 🇮🇸 🇪🇺 🎄open.substack.comIs Iceland getting ready to join the EU?A new change in Iceland’s government means that joining the EU is back on the cards for Iceland. 341210209
Reposted by Mickael PLOQUINCLaE @claeneuro.bsky.social · 23/12/2024Nature Spatial transcriptomic clocks reveal cell proximity effects in brain ageing www.nature.com/articles/s41...nature.comSpatial transcriptomic clocks reveal cell proximity effects in brain ageing - NatureA spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r... 03011
Reposted by Mickael PLOQUINDr. Ravi Ranjan, PhD California Health Sciences University, CA @methuselah1947.bsky.social · 22/12/2024www.linkedin.com/posts/stanfo...linkedin.comStanford Knight Initiative for Brain Resilience on LinkedIn: How do cellular neighbors shape the aging brain? Knight Initiative…How do cellular neighbors shape the aging brain? Knight Initiative researchers Anne Brunet and James Zou merge spatial transcriptomics and AI to uncover how… 032
Reposted by Mickael PLOQUINMickael PLOQUIN @mickp17000.bsky.social · 22/12/2024𝗦𝗽𝗮𝘁𝗶𝗮𝗹 𝗧𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰𝘀 𝗥𝗲𝘃𝗲𝗮𝗹𝘀 𝗘𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗚𝗿𝗮𝗱𝗶𝗲𝗻𝘁𝘀 𝗶𝗻 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗶𝗻𝗴 𝗪𝗵𝗲𝗮𝘁 𝗜𝗻𝗳𝗹𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝗰𝗲𝘀 𝗮𝘁 𝗖𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗥𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 www.biorxiv.org/content/10.1... 1209
Mickael PLOQUIN @mickp17000.bsky.social · 22/12/2024𝗦𝗽𝗮𝘁𝗶𝗮𝗹 𝗧𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰𝘀 𝗥𝗲𝘃𝗲𝗮𝗹𝘀 𝗘𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗚𝗿𝗮𝗱𝗶𝗲𝗻𝘁𝘀 𝗶𝗻 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗶𝗻𝗴 𝗪𝗵𝗲𝗮𝘁 𝗜𝗻𝗳𝗹𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝗰𝗲𝘀 𝗮𝘁 𝗖𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗥𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 www.biorxiv.org/content/10.1... 1209
Reposted by Mickael PLOQUINMickael PLOQUIN @mickp17000.bsky.social · 18/12/2024global-engage.com/product/webi... 022
Reposted by Mickael PLOQUINMathieu Bourdenx @mbourdenx.bsky.social · 19/12/2024Mindblowing paper creating spatial aging clocks 🤯🤯 ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors 151
Reposted by Mickael PLOQUINJohn Dupuis @dupuisj.bsky.social · 20/12/2024Republicans Cut Child Cancer Research From Funding Bill After Musk’s Meddling www.rollingstone.com/politics/pol...rollingstone.comRepublicans Cut Child Cancer Research From Funding Bill After Musk's MeddlingRepublicans removed funding for child cancer research from a new version of a bill to fund the government after Elon Musk torpedoed the previous deal. 068
Mickael PLOQUIN @mickp17000.bsky.social · 19/12/2024linkedin.comStanford Knight Initiative for Brain Resilience on LinkedIn: How do cellular neighbors shape the aging brain? Knight Initiative…How do cellular neighbors shape the aging brain? Knight Initiative researchers Anne Brunet and James Zou merge spatial transcriptomics and AI to uncover how… 031
Reposted by Mickael PLOQUINJames Zou @jameszou.bsky.social · 18/12/2024🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41... We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠 Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵 13813
Reposted by Mickael PLOQUINAriel K. Frame @arielframe.bsky.social · 18/12/2024BEAutiful study! Looking forward to perusing through this data. So thankful that it’s #openaccess I can’t be the only one excited, can I?media.tenor.coma man with his mouth open is making a funny face .ALT: a man with his mouth open is making a funny face . 1114
Reposted by Mickael PLOQUINHao Yin @haoyin.bsky.social · 18/01/2024Benchmarking 6 Imaging-based #SpatialTranscriptomics methods #MolecularCartography #Xenium #MERSCOPE #MERFISH #EELFISH #STARmapPLUS 🐭🧠 Mutually exclusive co-expression rate/MECR Who wins👑? #CosMx Not even in short list😔 #bioRxiv 2024 www.biorxiv.org/content/10.1... 032
Reposted by Mickael PLOQUINHao Yin @haoyin.bsky.social · 14/03/2024#SpatialTranscriptomics Developing Human Heart 12-13 pcw scRNAseq #MERFISH 238 cell type markers Analyzing the Cellular Communities Layered organization of ventricular #Cardiomyocytes can be directed by #Semaphorin-PlexinA intercellular signals🤠 #Nature 2024 www.nature.com/articles/s41... 044
Reposted by Mickael PLOQUINHao Yin @haoyin.bsky.social · 09/03/2024Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution e9.5/12.5/15.5 #ArterioVenousHierarchy & #Organotypicity of Embryonic #EndothelialCell scRNAseq #MERFISH #SpatialTranscriptomics #SciArt William Pu lab #CircRes 2024 www.ahajournals.org/doi/10.1161/... 022
Reposted by Mickael PLOQUINSanderson Center for Optical Experimentation @scope-umasschan.bsky.social · 17/12/2024Visit our website for more information about doing a merfish project and to discuss your project with SCOPE Staff @vizgen.bsky.social 043
Reposted by Mickael PLOQUINChristian Frezza @frezzalab.bsky.social · 18/12/2024Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Huge work from the @brunetlab.bsky.social www.nature.com/articles/s41...nature.comSpatial transcriptomic clocks reveal cell proximity effects in brain ageing - NatureA spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r... 1267
Reposted by Mickael PLOQUINBrunetLab @brunetlab.bsky.social · 18/12/2024Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵rdcu.beSpatial transcriptomic clocks reveal cell proximity effects in brain ageingNature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T... 2230296
Reposted by Mickael PLOQUINJohanna Joyce @johannajoyce.bsky.social · 18/12/2024Spatial transcriptomic clocks reveal cell proximity effects in brain ageing 🧠 🕙 Incredible study 🧪 in Nature from @brunetlab.bsky.social and the Zou lab 🎉 So many intriguing findings - including that T cells have a pro-ageing proximity effect on neighbouring cells 🤯 @natureportfolio.bsky.socialnature.comSpatial transcriptomic clocks reveal cell proximity effects in brain ageing - NatureA spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r... 16517
Mickael PLOQUIN @mickp17000.bsky.social · 18/12/2024nature.comSpatial transcriptomic clocks reveal cell proximity effects in brain ageing - NatureA spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r... 031
Reposted by Mickael PLOQUINEarlham Institute @earlhaminst.bsky.social · 17/12/2024💬 "We're excited to push the applications of this technology and collaborate with others to drive innovation and discovery." We've become one of five global Certified Service Providers for the @vizgen.bsky.social MERSCOPE platform, and the only site in the UK. #SpatialGenomics #SingleCelllinkedin.comEarlham Institute on LinkedIn: #spatialgenomics #cellularheterogeneity📣 Pleased to announce we're among the first Certified Service Providers for the Vizgen MERSCOPE platform, and the only site in the UK. Through the… 053
Reposted by Mickael PLOQUINCathleen O'Grady @cathleenogrady.bsky.social · 21/11/2024Remember Didier Raoult, the French microbiologist who set off the hydroxychloroquine craze? If you haven't been following, you might have missed that critics have pointed to ethical failings in hundreds of his papers – "ethical failings" meaning no or inadequate ethical approval. 311843
Reposted by Mickael PLOQUINCathleen O'Grady @cathleenogrady.bsky.social · 17/12/2024It took four days from submission to publication, and nearly five years from publication to retraction. After campaigning by many, many scientists, and an investigation by Elsevier, an infamous paper on hydroxychloroquine as a COVID-19 treatment has been retracted. 🧪 www.science.org/content/arti...science.orgInfamous paper that popularized unproven COVID-19 treatment finally retractedStudy on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds 371219510
Mickael PLOQUIN @mickp17000.bsky.social · 17/12/2024vizgen.com/vizgen-launc...vizgen.comVizgenIlluminating Biology to Advance Human Health 011
Reposted by Mickael PLOQUINDanielle Beckman @daniellebeckman.bsky.social · 12/12/2024"The brain microbiome: could understanding it help prevent dementia?" The answer to this question is yes. www.theguardian.com/lifeandstyle...theguardian.comThe brain microbiome: could understanding it help prevent dementia?Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases? 211341
Reposted by Mickael PLOQUINEarlham Institute @earlhaminst.bsky.social · 04/12/2024In a new technical blog, Senior Research Assistant Ashleigh Lister guides you through her workflow for employing @vizgen.bsky.social MERSCOPE technologies in #plant tissues, mapping out #gene activity in situ. www.earlham.ac.uk/articles/how... #SpatialTranscriptomics #PlantScience 🧪🌿earlham.ac.ukHow to use spatial transcriptomics to view single plant cells in situAshleigh Lister is a Senior Research Assistant in the Macaulay group. She is an expert in the field of plant spatial transcriptomics. In this technical article, she shares her insights, some top tips,... 052
Mickael PLOQUIN @mickp17000.bsky.social · 03/12/20241. Integrated analysis of >250,000 single cells from 70 healthy spanning 13 niches 2. Spatial proteomics and transcriptomics (MERSCOPE) atlases comprised of >2 million cells 3. iIntroduce AstroSuite advanced AI-assisted bioinformatics toolkit www.biorxiv.org/content/10.1... 092
Reposted by Mickael PLOQUINMickael PLOQUIN @mickp17000.bsky.social · 21/11/2024Nominating this paper for paper of the year ! Such a stunning work from Xiaowei lab. www.biorxiv.org/content/10.1...biorxiv.orgA platform for multimodal in vivo pooled genetic screens reveals regulators of liver functionOrgan function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the... 054
Reposted by Mickael PLOQUINEarlham Institute @earlhaminst.bsky.social · 27/11/2024📽️ Our recent webinar with @vizgen.bsky.social is now available to watch on demand. Earlham Institute scientists shared their journey of working with the MERSCOPE #SpatialTranscriptomics platform, offering insights on their methods for working with non-model samples. us02web.zoom.us/rec/componen... 1104
Mickael PLOQUIN @mickp17000.bsky.social · 21/11/2024Nominating this paper for paper of the year ! Such a stunning work from Xiaowei lab. www.biorxiv.org/content/10.1...biorxiv.orgA platform for multimodal in vivo pooled genetic screens reveals regulators of liver functionOrgan function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the... 054
Mickael PLOQUIN @mickp17000.bsky.social · 20/11/2024www.science.org/content/arti...science.orgLike ‘old Twitter’: The scientific community finds a new home on BlueskyAfter recent changes to Elon Musk’s X, a gradual migration turns into a stampede 0104
