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Mathieu Bourdenx

@mbourdenx.bsky.social
480 followers 688 following 26 posts

Neuroscientist at @UKDRI at UCL working on Ageing and Dementia. 🧠 Dad x2 Serial procrastinator

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Mathieu Bourdenx @mbourdenx.bsky.social · 12/08/2026
Few more days to apply to the postdoc in our group to study the mechanisms of interstasis. If you like big questions, ambitious science and deeply collaborative work, get in touch! 🧠 www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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UK Dementia Research Institute @ukdri.ac.uk · 27/07/2026
How might neurons protect themselves from toxic protein build-up?🧠 @ulelab.bsky.social & @mbourdenx.bsky.social have been awarded £3.8m by @wellcometrust.bsky.social to study role of interstasis in protecting neurons ukdri.ac.uk/news-and-eve... @kingsioppn.bsky.social @uclbrainscience.bsky.social
ukdri.ac.uk
Two UK DRI Group Leaders awarded major Wellcome funding to study protective mechanisms against neuron damage and ageing
A new study, co-led by researchers at the UK DRI at King’s and the UK DRI at UCL will investigate how neurons can protect themselves from toxic protein accumulation, with implications for neurodegener...
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Mathieu Bourdenx @mbourdenx.bsky.social · 19/05/2026
Fantastic work! CoppaFISH is an open source, cheap, 3D (🤯) spatial transcriptomics method that can be aligned to multiple modalities: in vivo 2P recordings (🤯🤯), immunostainings, and more! Congrats to all the authors and happy to have been able to contribute!
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Andrew White 🐦‍⬛ @andrew.diffuse.one · 29/10/2025
Making "AI Scientists" has become a hot topic lately. The first reference I could find was from 2008. The term has been used for 20 years! Like "Adam," an AI Scientist robot for studying yeast was published in 2009. I wrote a short post about the term and what it means now. diffuse.one/p/w1-001
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UK Dementia Research Institute @ukdri.ac.uk · 26/09/2025
Meet our new Future Leader Fellows!👏 Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org ⬇️ Read more about their work👉 buff.ly/JOH2d9N
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UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 25/09/2025
🤖 Could an AI scientist help unlock the secrets of dementia? Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research. buff.ly/O8RjZIX #UCLDementia #WorldAlzheimersMonth
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UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 16/09/2025
Huge congratulations to Dr @angelikaza.bsky.social and Dr @mbourdenx.bsky.social who have both been awarded @ukri.org Future Leaders Fellowships! 🙌 @uclqsion.bsky.social @ukdri.ac.uk Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
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UCL News @uclnews.bsky.social · 22/09/2025
“Ultimately, I see AI leading to an acceleration in discovery in dementia research that could be transformative for patients" says Dr @mbourdenx.bsky.social @ukdri.ac.uk, who is working with an "AI scientist", a system that can analyse data and suggest new research directions not yet explored
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benjamindehay.bsky.social @benjamindehay.bsky.social · 18/06/2025
I’m very happy 🥳 to share our new collaborative work, out today in Science Advances! Many thanks to all the co-authors! Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
science.org
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates
Distinct α-synuclein assemblies trigger distinct neurotoxic cellular pathways.
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Gabriela K Popescu @popstarlab.bsky.social · 28/03/2025
"The biggest mystery is not why arXiv succeeded. Rather, it’s how it wasn’t killed by vested interests intent on protecting traditional academic publishing." www.wired.com/story/inside...
wired.com
Inside arXiv—the Most Transformative Platform in All of Science
Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.
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Mathieu Bourdenx @mbourdenx.bsky.social · 02/03/2025
Flabbergasting www.theatlantic.com/health/archi...
theatlantic.com
Inside the Collapse at the NIH
Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Randall Munroe @xkcd.com · 26/02/2025
RNA xkcd.com/3056
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Clémence Guetté @clemenceguette.bsky.social · 20/02/2025
Sur les retraites, Bayrou a menti. Le "déficit caché" des retraites n’a jamais existé. Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030. La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
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Mathieu Bourdenx @mbourdenx.bsky.social · 12/02/2025
🚨Cool Job Alert 🚨consider joining this amazing and rocknroll lab
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Melanie D’Arrigo @darrigomelanie.bsky.social · 08/02/2025
Tesla paid $0 in federal income tax last year. 2022: $0 2021: $0 2020: $0 2019: $0 2018: $0 Tesla reported $6.7 billion in profit in those years.
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Sonia Garcia-Ruiz @soniagr.bsky.social · 27/01/2025
New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...
nature.com
Splicing accuracy varies across human introns, tissues, age and disease - Nature Communications
Inaccuracies in RNA splicing may play a significant role in aging and disease. Here, the authors present a comprehensive characterization of splicing accuracy across over 14,000 human samples, offerin...
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Mathieu Bourdenx @mbourdenx.bsky.social · 25/01/2025
After spending 4 years in the USA for my postdoc and my daughter being born there, it always felt (and still feels like!) a second home. So it’s utterly sad to see what’s happening now. I stand with all my American friends! Resist ✊💪
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Clémence Guetté @clemenceguette.bsky.social · 25/01/2025
Notre programme est prêt. Nous sommes au travail. Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable. www.leparisien.fr/elections/pr...
leparisien.fr
Avec son nouveau programme, LFI fait un pas de plus vers la présidentielle
EXCLUSIF. Le mouvement de Jean-Luc Mélenchon a mis à jour son programme, l’Avenir en commun, et se prépare plus que jamais à une nouvelle él
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Mathieu Bourdenx @mbourdenx.bsky.social · 20/01/2025
That’s completely crazy ! And worrisome …
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Mathieu Bourdenx @mbourdenx.bsky.social · 13/01/2025
Still waiting to see most UK and French universities to do the same …
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Constantin Ahlmann-Eltze @const-ae.bsky.social · 03/01/2025
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 www.nature.com/articles/s41... LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️
Overview of the LEMUR steps: (1) subspace alignment, (2) differential expression, (3) DE neighborhoods, (4) pseudobulking.
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Ming Tommy Tang @tommytang.bsky.social · 30/12/2024
🔥 chatomics! I regret not learning this well in college—and it changed how I approach bioinformatics today. Here’s my story and why you should avoid my mistake. 🧬
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Mathieu Bourdenx @mbourdenx.bsky.social · 26/12/2024
Paper alert from the Duff Lab 🚨🚨 My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!
nature.com
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
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Mathieu Bourdenx @mbourdenx.bsky.social · 19/12/2024
Mindblowing paper creating spatial aging clocks 🤯🤯 ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors
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Mathieu Bourdenx @mbourdenx.bsky.social · 29/11/2024
Help from the MRI community needed: I would like to plot simple regional expression of a protein in the Schaefer atlas. I have a vector of values per region for the atlas. I can’t seem to find my way around that simple thing. Any help will be appreciated!! @nilearn.bsky.social ?
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Mathieu Bourdenx @mbourdenx.bsky.social · 25/11/2024
It seems that a lot of people have transitioned from X to here, however I feel that institutes/centres/unis are still missing. Did you try to convince yours to move? If so, how?
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Sam Rodriques @sgrodriques.bsky.social · 20/11/2024
New on BioRxiv: We report a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body. Paper here: www.biorxiv.org/content/10.1... 1/
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BrunetLab @brunetlab.bsky.social · 22/11/2024
Aging starter pack! go.bsky.app/5UXXaDA
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Jean-François Cudennec @limpetnerd.eurosky.social · 20/11/2024
I will not hide my inner convictions anymore. Be the change you want to see in the world ! #AcademicSky 🧪
A man holds a sign in the street saying « stop asking for slides a week in advance of a talk »
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Mathieu Bourdenx @mbourdenx.bsky.social · 21/11/2024
So happy to this story led by Steph Fowler (Duff lab at UCL, now leading her own lab at Oxford) finally out. Amazing to see tau filaments in situ! Now I want to know what is this additional density and what is the tether!
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Mathieu Bourdenx @mbourdenx.bsky.social · 20/11/2024
Sounds like a fascinating approach!
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James Catterson @scotsfriction.bsky.social · 19/11/2024
🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians. Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋 go.bsky.app/S6FfsTp
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Alan Murphy @al-murphy.bsky.social · 18/11/2024
Delighted to share our work to develop a genomic DNN, Enformer Celltyping, to accurately predict epigenetic signals in previously unseen cell types has now been published doi.org/10.1038/s414...
doi.org
Predicting cell type-specific epigenomic profiles accounting for distal genetic effects - Nature Communications
Enformer Celltyping is a genomic deep learning model that predicts epigenetic signals in unseen cell types using distal DNA interactions and chromatin accessibility data. Here, authors show it general...
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