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Melissa Franch, PhD

@mfranch.bsky.social
1.1K followers 1.9K following 55 posts

Postdoc in the Hayden lab at Baylor College of Medicine studying neural computations of natural language & communication in humans. Sister to someone with autism. F32 NIDCD Fellow | Autism Research Institute funded | Simons F2F | she/her. melissafranch.com

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Reposted by Melissa Franch, PhD
Elliot Murphy @elliot-murphy.bsky.social · 15/09/2026
New work out today! The result of a 15 year project to offer genuine linking hypotheses between linguistics and neuroscience: a revised research program, and its first result - a novel neural binding operation ('Meld') capturing core properties of natural language syntax 🧵 arxiv.org/abs/2609.14384
arxiv.org
Formal Properties of Language as Constraints on Neural Dynamics
What must a neural system be capable of to implement language? Current research annotates stimuli with linguistic variables and tests which electrodes, voxels, or language-model layers predict neural ...
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Nina Miolane @ninamiolane.bsky.social · 22/07/2026
Our review on superposition in AI & brains is published in @nature.com #Machine #Intelligence 🌐 Neural networks encode concepts in superposition. We can recover them in 3 steps: identifiability, compressed sensing, interpretability. W/ @david-klindt.bsky.social O'Neil Reizinger & Maurer 🌟
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Nicole Rust @nicolecrust.bsky.social · 11/09/2026
The Grand Plan for brain & mind research is in terrific hands with the researchers at Baylor College of Medicine! From an excellent panel discussion across silos to many insightful conversations with PIs and trainees, I'm a bit blown away by what they are up to here. Impactful & exciting.
Poster for Reimagining Brain Therapies
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Ben Hayden @benhayden.bsky.social · 09/09/2026
And of course, a great source on why cell types like "place cell" aren't a natural kind: www.biorxiv.org/content/10.1...
biorxiv.org
The inevitability and superfluousness of cell types in spatial cognition
Discoveries of functional cell types, exemplified by the cataloging of spatial cells in the hippocampal formation, are heralded as scientific breakthroughs. We question whether the identification of c...
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Reposted by Melissa Franch, PhD
Ben Hayden @benhayden.bsky.social · 09/09/2026
And in some patients we measured gaze as well. We find that gaze has its own maps, and those are also semi-orthogonalized. So in debates about whether primate hippocampus does gaze or place, the answer is “both, and their codes are rotated”.
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Niklas Buergi @niklasbuergi.bsky.social · 09/09/2026
Autism has long been linked to difficulties with Theory of Mind. But what exactly is driving these differences? And what happens in the brain? In our new preprint, we show that adaptive mentalization might be key. A 🧵 #CogSci #CogNeuro osf.io/preprints/ps...
Repeated Rock-Paper-Scissors task used to study adaptive mentalization, alongside a schematic showing increasingly sophisticated reasoning strategies, from responding to past actions to trying to guess the opponent’s prediction about one’s own next action
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Reposted by Melissa Franch, PhD
Seth Koslov @skoslov.bsky.social · 19/08/2026
New preprint! Posterior cingulate is often linked to memory in humans but decisions in monkeys yet there's little consensus about its functional neuroanatomy. We recorded LFPs+single units in humans during matched value and memory based decisions, finding convergence in dorsal, but not ventral, PCC.
biorxiv.org
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Nicole Rust @nicolecrust.bsky.social · 04/09/2026
The superposition of these two studies — both incredible — reflect a snapshot of "one big thing" systems neuroscience has yet to resolve. In mice: 1. Task-related signals are everywhere. 2. Absent large swaths of "everywhere," suprisingly sophisticated learning & behavior remains.
Post by Enny van Beest, "Brainwide representation of navigation"Post by Jieyu Zheng, "How fast can mice learn complex mazes?"
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Enny van Beest @ennyvb.bsky.social · 04/09/2026
Textbook: tracking position during navigation is primarily the job of the hippocampus. Recent findings suggest a more complicated story. Recording >20k neurons brainwide, we indeed find spatial representations in every region! With @kenneth-harris.bsky.social and @carandinilab.net
Brainwide representations of a virtual corridor
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Tom McCoy @rtommccoy.bsky.social · 01/09/2026
🤖🧠NEW PAPER🧠🤖 (The result of an 8-year project!) LLMs seem very different from symbolic systems. Yet LLMs excel in symbolic domains (e.g., language/code/math). How do they do it? Our finding: LLM representations have implicit symbolic structure! Link in thread ⬇️ 1/n
Overview of the paper. 
Title: The Emergent Symbolic Structure of Artificial Neural Networks
Authors: Tom McCoy, Paul Soulos, Tal Linzen, Paul Smolensky
Left: Neural networks encode information in vectors (there is then an image of a vector), yet they excel at tasks long thought to require symbolic structure (there is then an image of a symbolic representation, specifically a syntax tree). How do LLMs do it?
Right: We find that LLM representations can be closely approximated with symbolic structures. This approximation lets us edit the structure of an LLM’s output by editing the structure of its internal representations, as shown. There is then an image of two edits to LLMs. In the first one, the original input is 3 + 6 * 8, with an answer of 51. But if we swap the positions of the 3 and the 6, the output becomes 30. In the second one, the original input is a Python command repeating the list [Z, U] three times, producing [Z, U, Z, U, Z, U]. But if we edit the input in a way that adds a Q at the end of the input, the output becomes [Z, U, Q, Z, U, Q, Z, U, Q].
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Eliza Bliss-Moreau @eblissmoreau.bsky.social · 31/08/2026
My dept/area is hiring! We're open to animal species/model and research area. UCD is an amazing place to do nonhuman animal work - major 🐒 center, a band new rodent vivarium in the Psych building, and capacity to house all sorts of other animals! recruit.ucdavis.edu/JPF07812
recruit.ucdavis.edu
Assistant Professor of Psychology - Biological Bases of Behavior
University of California, Davis is hiring. Apply now!
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Reposted by Melissa Franch, PhD
Tim Kietzmann @timkietzmann.bsky.social · 31/08/2026
Check out our new TICS article! We present an alternative take on the widely observed alignment between various AI models and human brain representations: the Umwelt Representation Hypothesis.
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Jean-Paul Noel @jpnoel.bsky.social · 29/08/2026
First Noel Lab Pre-print! If you are into "peri-personal space" and feel like we need more single cell recordings, this one is for you! www.biorxiv.org/content/10.6...
biorxiv.org
An egocentric map prioritizing peri-personal space in the mouse rostro-lateral visual area
All physical interactions between an organism and its environment occur within the space immediately adjacent to and surrounding its body, its peripersonal space (PPS). This space has been extensively...
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Reposted by Melissa Franch, PhD
The Transmitter @thetransmitter.bsky.social · 24/08/2026
With agentic AI’s rapid infiltration into science, researchers need to develop AI use policies and practices, writes @nicoschuck.bsky.social. #neuroskyence www.thetransmitter.org/artificial-i...
thetransmitter.org
How, when and why to use agentic AI in our neuroscience labs
With agentic AI’s rapid infiltration into science, researchers need to develop AI use policies and practices.
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Reposted by Melissa Franch, PhD
Herbert Wu @herbertwu.bsky.social · 20/08/2026
First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. (1/3) www.nature.com/articles/s41...
nature.com
Asymmetric prefrontal representations for leader–follower dynamics - Nature
Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
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Ryuto Yashiro @ryuto-yashiro.bsky.social · 11/08/2026
Excited to share our new paper: "Probing the content of semantic representations in body-selective regions" We propose a framework based on object co-occurrence to interpret semantic representations of natural scenes predicted by LLM embeddings. doi.org/10.1162/IMAG...
doi.org
Probing the content of semantic representations in body-selective regions
Abstract. Recent advances in neural networks trained on natural language have revealed that category-selective regions encode complex semantics and contextual information of natural scenes in addition...
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Reposted by Melissa Franch, PhD
Sam Nastase @samnastase.bsky.social · 18/08/2026
New perspective piece out in @cp-neuron.bsky.social with Zaid Zada, @adelegoldberg.bsky.social, and Uri Hasson! We try to articulate some of our excitement about LLMs and discuss what kinds of insights they might provide into the neural computations supporting natural language in the human brain.
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Stories of WiN @storiesofwin.bsky.social · 05/08/2026
Our latest profile is here! Dr. Lea Duncker (@leaduncker.bsky.social) uses statistical and theoretical approaches to study the neural basis of flexible behavior. Follow the link below to learn more! #StoriesOfWiN #WomenInNeuroscience www.storiesofwin.org/profiles/202...
storiesofwin.org
Dr. Lea Duncker — Stories of WiN
uses statistical and theoretical approaches to study the neural basis of flexible behavior
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Reposted by Melissa Franch, PhD
Kanaka Rajan @kanakarajanphd.bsky.social · 07/08/2026
(1/8) Our approach for untangling brain-wide interactions is out today in @cp-neuron.bsky.social! Current-Based Decomposition (CURBD) uses RNNs constrained by real neural data to reveal the input driving neurons, uncovering how brain regions talk to each other. doi.org/10.1016/j.ne... 🧵👇
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Nicole Rust @nicolecrust.bsky.social · 07/08/2026
US scientists: Going into fall 26, how are you thinking about things? Following Fall 24 events and a tumultuous spring 25, I remember a convo with a colleague in which we agreed we just needed to wait things out until fall 25 and we'd have some clarity about the landscape (eg for funding). /1
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Lorenzo Posani @lorenzoposani.com · 06/08/2026
For a neural circuit to be "specialized", does it need specialized neurons? In our new work - now out in @NatureNeuro - we address this question in the BLA, using representational geometry to propose a new population-centric way of defining circuit specialization. 🧵👇 1/
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Greta Tuckute @gretatuckute.bsky.social · 03/08/2026
CCN time--come say hi! @cogcompneuro.bsky.social
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Iris Groen @irisgroen.bsky.social · 31/07/2026
And on Wednesday afternoon it's time for our Community Event that focuses on what neural encoding models are useful for, where I'll be showcasing several cool projects on EEG encoding during scene perception led by @niklasmuller.bsky.social! 2026.ccneuro.org/community-ev...
2026.ccneuro.org
Community Event – So You Have a Highly Predictive Model, Now What? Translating Neural Encoding Models into Scientific and Engineering Impact
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Iris Groen @irisgroen.bsky.social · 31/07/2026
Then on Wednesday, double whammy: in the morning I'll present a poster on our hot-of-the-press EEG decoding study on neural representational dynamics between images vs. video, led by @annewzonneveld.bsky.social (Poster C85) openreview.net/forum?id=njG...
2026.ccneuro.org
Poster Presentation
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Elise Piazza @elisepiazza.bsky.social · 03/08/2026
This project is one of our greatest undertakings as a lab, with Calli at the helm (in terms of data collection, transcription of speech features during naturalistic dialogue, and computational modeling), and we're excited to get everyone's feedback!
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Melissa Franch, PhD @mfranch.bsky.social · 31/07/2026
I'm over the moon to be recognized for my future plans in (and lifelong commitment to) autism neuroscience research through earning the Simons Foundation Fellows To Faculty award! I can't wait to dive into this work alongside this community✨🥹
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IMB @imb-uofsc.bsky.social · 23/07/2026
How does your brain register whether something feels good or bad? New research had people listen to stories in an MRI scanner and found the brain maps feelings on a single scale from unpleasant to pleasant, using far more regions than expected. #Valence, #Naturalistic Link: doi.org/10.64898/202...
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Lorenzo Posani @lorenzoposani.com · 15/07/2026
Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!
nature.com
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
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Biyu Jade He @biyuhe.bsky.social · 09/07/2026
New paper alert from our lab! nature.com/articles/s41... We used stimuli sequences following 1/f statistical patterns—an ubiquitous statistical structure in natural stimuli—to probe predictive processing in the human brain. How does the brain predict upcoming sensory inputs based on past inputs?
nature.com
Neural mechanisms of time-forward predictions for naturalistic auditory tone sequences - Nature Communications
A longstanding question is how the brain predicts complex, naturalistic sensory events and updates those predictions when expectations are violated. Using intracranial recordings, the authors show tha...
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Ye Lab @liye-tsri.bsky.social · 02/07/2026
Our new preprint is out!! The human brain runs on ~20 watts. Computers and modern AI systems require vastly higher energy. This gap raises a fundamental question: how does the brain compute so efficiently? In our new study, we take a critical step toward measuring and understanding this directly 1/3
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Jeremy Berg @jeremymberg.bsky.social · 30/06/2026
Glad to see this story and coverage of an important paper. www.statnews.com/2026/06/17/n... 1/16
statnews.com
NIH diversity programs doubled undergraduates’ odds of getting a Ph.D., 20-year study finds
A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.
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Shervin Safavi @neuroprinciplist.bsky.social · 09/06/2026
1/11 Happy to share our TICS paper on using the flexibility of one of the most basic cognitive functions, perception, to understand one of the most complex cognitive dysfunctions, psychiatric conditions (also my first formal work in computational psychiatry 🎉) 📄: www.cell.com/trends/cogni... 🧵 : 👇
cell.com
Perceptual multistability: a multifaceted window into brain dysfunctions
Perceptual multistability, observed across species and sensory modalities, offers valuable insights into numerous cognitive functions and dysfunctions. For instance, differences in temporal dynamics a...
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Melissa Franch, PhD @mfranch.bsky.social · 25/06/2026
Congratulations @xinyuanyan.bsky.social! I’m so grateful to do neuroscience with you. Your blog post provides a clear summary of the research and illustrates your strong skills in communicating your science!
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Ben Hayden @benhayden.bsky.social · 24/06/2026
New lab paper ! "Shared neural geometries for bilingual semantic representations in human hippocampal neurons" led by @xinyuanyan.bsky.social. 🧵 www.sciencedirect.com/science/arti...
sciencedirect.com
Shared neural geometries for bilingual semantic representations in human hippocampal neurons
The human brain has the remarkable ability to comprehend and express similar concepts in multiple languages. To understand how it does so, we examined…
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Cell Press @cellpress.bsky.social · 24/06/2026
For many bilingual people, switching between languages feels effortless. Now, scientists have figured out how bilingual brains accomplish this feat at the single neuron level. spkl.io/633297EUXJ Xinyuan Yan, Benjamin, Y. Hayden, @sameershethmd.bsky.social & colleagues @cp-cell.bsky.social
first page of Cell paper: “Shared neural geometries for bilingual semantic representations in human hippocampal neurons"
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Eleonora Bartoli @elebartoli.bsky.social · 24/06/2026
Some neurons like to ride on slow LFP oscillations, regardless of their phase! This might represent a mechanism to coordinate neural activity and propagate information across brain circuits 🧠 amazing collaboration led by the super talented @zahrajourahmad.bsky.social and Andrew Watrous!
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 12/06/2026
Many of the scientific questions we're interested in tackling require studying learning over long periods of time across the brain. This is challenging – which is why we're excited to say we've been developing a system for chronic wireless recording using long Neuropixels probes in macaque monkeys.
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Yifei He 何奕菲 @yifeihe.bsky.social · 09/06/2026
Very happy that our manuscript with my brilliant collaborators @jamestrujillo.bsky.social and @straubeb.bsky.social is now published @jneurolang.bsky.social. 🥳🥳🥳 Interested in gesture, discourse, fMRI, prediction, computational modeling? This is the paper for you 👇 doi.org/10.1162/NOL....
doi.org
Discourse context and co-speech gestures jointly shape hierarchical prediction during the processing of a multimodal narrative
Abstract. Understanding one another in daily communication depends on predicting language from prior discourse context and visual signals, such as co-speech gestures. However, it remains unclear how d...
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CosmicRami 🏳️‍🌈🏳️‍⚧️ @rami.spaceaustralia.com · 02/06/2026
If you're looking to queer up your timelines with enriching STEM content this #Pride, then @prideinstem.bsky.social has you covered with these three excellent starter packs! go.bsky.app/BFc4wgf go.bsky.app/Cw9bRYZ go.bsky.app/Cw9bRYZ Lift queer voices this month!
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Stories of WiN @storiesofwin.bsky.social · 27/05/2026
Check out our latest profile! Dr. Megan Peters (@meganakpeters.bsky.social) studies how the brain represents & uses uncertainty and she also co-founded the online summer school, Neuromatch Academy. Learn more at the link below! #WomenInNeuroscience #StoriesOfWiN www.storiesofwin.org/profiles/202...
storiesofwin.org
Dr. Megan Peters — Stories of WiN
studies how the brain represents and uses uncertainty and she also co-founded the online summer school, Neuromatch Academy
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Harsha Gurnani @harshag.bsky.social · 27/05/2026
Info. processing, memory, adaptive decisions.. none of it fully captures what makes us intelligent *beings* with subjective experience. @meganakpeters.bsky.social thinks hard about that gap and how to formalize that in theory & expmt. And she somehow found time to co-build @neuromatch.bsky.social 🤩
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Thomas Yeo @bttyeo.bsky.social · 21/05/2026
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N
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Nicole Rust @nicolecrust.bsky.social · 18/05/2026
My new @thetransmitter.bsky.social piece. Does Claude AI have emotions? *No*. Does Claude have nontrivial emotion-equivalents? *Yes*. Like your "memory" vs your laptop's; similar but not the same. Here, I unpack why that's interesting. www.thetransmitter.org/emotion/what...
thetransmitter.org
What can AI teach us about ‘emotions’?
Exploring why Anthropic’s AI, Claude, displays something like emotion could ultimately help us better understand the function that emotions serve in humans.
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Jeff Yau 姚明穎 @jeffmyau.bsky.social · 17/05/2026
Another successful New-Bee 🐝 neuro program in the 📚! We were delighted to host Elkins HS for a day of neuroscience demos and lessons. The future is bright with these future STEM leaders! 🤩 Special thanks to generous support from @bcmneurosci.bsky.social and @rsb.org.uk.
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Xinyuan Yan @xinyuanyan.bsky.social · 06/05/2026
Polysemanticity in human hippocampal neurons. When single neurons encode word meanings (concepts), they use the computational principle of superposition.
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Eric Cole @ecolibutneuro.bsky.social · 06/05/2026
The anesthetized hippocampus processes language! I've really enjoyed working with new devices for human neuroscience and moving this project forward during my early work at BCM
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Jay Hennig @jhennig.bsky.social · 05/05/2026
🥳 Super excited to share our lab's first preprint, led by @hungyun.bsky.social "Distinct tasks engage shared neural subspaces in human hippocampus and anterior cingulate cortex" www.biorxiv.org/content/10.6... 🧵(1/9)
biorxiv.org
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Joe Barnby @joebarnby.com · 28/04/2026
502 adolescents (15-17) played an interactive pre-task Cyberball, where they were either excluded or included, and then took part in the Intentions Game (elifesciences.org/articles/104...) to make and predict another's social decisions. We examined both behavioural and computational outcomes...
elifesciences.org
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Andrew D Wilson @adw.bsky.social · 20/04/2026
“…the binding problem may be an artifact of theoretical assumptions rather than a real computational challenge for the brain…we propose a framework where the visual cortex represents naturally co-occurring patterns of information rather than processing isolated features that need binding.”
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Hugo Spiers @hugospiers.bsky.social · 17/04/2026
Risk reshapes amygdala representation of choice "...these findings reveal how dynamic reshaping of choice-related basolateral amygdala representations underpins behavioral flexibility in the face of risk." www.cell.com/neuron/fullt...
cell.com
Risk reshapes amygdala representation of choice
Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactiv...
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