Additional Links Faculty Resources Faculty Highlight Videos Faculty Faculty Awards The 2026-2027 faculty search is now open. Department of Biochemistry, School of Medicine—Basic Sciences Vanderbilt Un...

Biayna, Baranovskii and colleagues report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the periphery of nuclear speckles and undergo synchronou...

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

Cameron et al. show that dormant pre-replication complexes are removed upon collision with replication forks in Xenopus egg extracts. They identify FANCJ and RTEL1 as key factors in this process and s...

DNA replication forks frequently encounter obstacles and remodel into four-way junctions to actively slow DNA fork progression. Fork slowing can also spread to undamaged forks via an ATR-dependent mec...

Transcription condensates are dynamic, phase-separated compartments that control gene activation. Here, we present a protocol for studying transcripti…

The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.

This Prize was created to recognize that global economic health is dependent upon a vibrant research community and we need to encourage our best and brightest to continue in their chosen fields of res...

Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

Li et al. uncover a new mechanism, fork-MMEJ, at broken replication forks that repairs seDSBs with characteristics distinct from the canonical MMEJ (cMMEJ). This study provides insights into replication-associated DSB repair, implicates microhomology-mediated chromosomal rearrangements in cancer, and offers potential therapeutic strategies to selectively target cancer cells.

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases t...