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Sidrit Uruci (Sid)

@sidrituruci.bsky.social
265 followers 223 following 4 posts

PhD in @luijsterburglab at @LUMC_Leiden, previously in @Tanejalab at @ErasmusMC. Science lover, DNA enthusiast. European child 🇪🇺🇳🇱🇮🇹🇦🇱🏳️‍🌈

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Reposted by Sidrit Uruci (Sid)
Andrew Blackford @andrewblackford.bsky.social · 24/08/2026
Our latest work describing DDIAS as a new component of the TOPBP1-CIP2A pathway in mitosis and its requirement for brain development is now published. Fantastic collaboration with @fenaochs.bsky.social, @profstewartlab.bsky.social, Lars Allan Larsen, @tcr-miller.bsky.social, Zafar Iqbal & others
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Sidrit Uruci (Sid) @sidrituruci.bsky.social · 17/05/2026
Small contribution to the eternal match happening inside every cell: in the red corner, replication. In the blue corner, transcription. Both convinced they own the genome. Another amazing collaboration with @hamperllab.bsky.social and @luijsterburglab.bsky.social lnkd.in/ey9tH7YF
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Reposted by Sidrit Uruci (Sid)
Genome Function Lab @genomefun.bsky.social · 24/04/2026
Our new paper is finally out! 📢 Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab. Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social
science.org
Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed
Slowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.
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Reposted by Sidrit Uruci (Sid)
Kumar Somyajit & Lab @ksomyajit.bsky.social · 29/01/2026
Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt
rdcu.be
PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.
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Sidrit Uruci (Sid) @sidrituruci.bsky.social · 15/01/2026
I'm beyond excited and thrilled to share that my first (co)-first-author research paper has been published in Nature 🎉 If I say Transcription-Replication Conflict, do cilia proteins pop in your head? No? Well, understandable, but you'd be wrong! Intrigued? Then read this paper!
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Reposted by Sidrit Uruci (Sid)
Luijsterburglab @luijsterburglab.bsky.social · 01/08/2025
Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org
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Reposted by Sidrit Uruci (Sid)
Luijsterburglab @luijsterburglab.bsky.social · 09/04/2025
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
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Reposted by Sidrit Uruci (Sid)
Marcel Werner @marcelwerner.bsky.social · 20/02/2025
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇
academic.oup.com
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
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Reposted by Sidrit Uruci (Sid)
Sophie van der Horst @sophievdhorst.bsky.social · 08/02/2025
Very happy to share that our work on identifying and characterizing factors affecting DNA replication is published by Nature Communications!
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Reposted by Sidrit Uruci (Sid)
bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 21/11/2024
RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription www.biorxiv.org/content/10.1101/202…
biorxiv.org
RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1
Independently of the pathways or circuits deregulated in cancer cells, these present altered transcr
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