Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine life to postnatal, extrauterine life. This Review highlights recent advances in our understanding of perinatal immune plasticity and the factors that modulate it, with implications for neonatal health and disease.

Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid.

A natural experiment comparing recipients of the live attenuated versus recombinant herpes zoster vaccines found that the recombinant vaccine was associated with a lower incidence of cardiovascular events across 7 years of follow-up.

Study Design.Retrospective cohort study.Objective.To evaluate the characteristics and outcomes of low threshold screws (LTS) identified through...

Study Design.Prospective multicenter cohort study.Objectives.To investigate the impact of symptom duration on surgical outcomes and functional...

Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

The authors provide a multiomic single-cell and spatial atlas of Crohn’s disease, focusing on the crosstalk between immune and stromal cells and heterogeneity around mucosal lesions.

This whole-genome sequencing study based on 7,851 parent−offspring families shows that parental age and assisted reproductive technologies influence the number and types of de novo mutations, highlighting potential health impacts and the need to optimize reproductive practices.

Trained on 2.3 million whole-slide images and 14 million clinical question−answer pairs, the multimodal foundation model PRISM2 matched clinical-grade cancer detection performance without task-specific training, demonstrating the value of clinical dialogue supervision for computational pathology.

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In a pair of pivotal phase 3, placebo-controlled, randomized clinical trials, the oral JAK1 inhibitor povorcitinib significantly reduced abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa.