A 54-year-old woman presents with subacute exertional dyspnea after heavy lifting and a history of chronic repetitive upper-limb strain from caregiving. What would you do next?

This secondary analysis of a randomized clinical trial evaluates whether frailty modifies the efficacy and safety of the GLP-1 RA semaglutide in adults with cardiovascular disease and overweight/obesity.

This randomized clinical trial analyzes whether finerenone lowers blood pressure and whether its cardiovascular benefits in patients with mildly reduced or preserved ejection fraction heart failure depend on baseline blood pressure or blood-pressure reduction.

This case report discusses a case of nonbacterial thrombotic endocarditis in an adult male with non–small cell lung cancer.

This case report discusses instantaneous cardiac tamponade due to hemorrhagic pericardial effusion captured on computed tomography imaging in a previously hemodynamically stable patient with acute chest pain.

This narrative review discusses the current and emerging role of right ventricular–focused imaging and hemodynamic parameters as end points in clinical trials and a comprehensive framework for their development, validation, and broader implementation.

This economic evaluation examines Medicare-linked registry data to estimate the 1-year health care cost offset and net cost associated with using quadruple guideline-directed medical therapy after hospitalization for heart failure with reduced ejection fraction.

This systematic review and meta-analysis evaluates the safety and efficacy of abbreviated dual antiplatelet therapy durations in patients at high bleeding risk undergoing percutaneous coronary intervention.

This ad hoc analysis of a randomized clinical trial reports on the 7-year outcomes among a group of low-risk patients with symptomatic severe aortic stenosis treated with transcatheter aortic valve replacement vs surgery.

This randomized clinical trial assesses the use of aficamten vs metoprolol for exercise in patients with obstructive hypertrophic cardiomyopathy.

This cohort study among UK Biobank participants assesses whether inflammatory biomarkers may modify lipoprotein(a)-associated risk for coronary artery disease and aortic stenosis in a primary prevention population.

This randomized clinical trial evaluates the progression of coronary artery calcification compared with placebo over a 2-year period.

This nonrandomized clinical trial evaluates the safety and preliminary efficacy of administration of AAVrh.10hFXN to adults as gene therapy to treat Friedreich ataxia cardiomyopathy.

In this issue of JAMA Cardiology, Vossen et al1 report the results of a randomized clinical trial investigating whether supplementation with the vitamin K homologue menaquinone-7 (MK-7) at a daily dose of 360 µg would delay progression of coronary artery calcification. Among 180 patients with...