Background: Clinical guidelines recommend bisphosphonates for complex regional pain syndrome (CRPS) despite limited evidence of efficacy. Purpose: To determine the efficacy and safety of bisphosphonat...

The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....

An abstract is unavailable.

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Background In 2019, the FDA and EMA approved intranasal esketamine for treatment resistant depression (TRD). The current study re–evaluated its efficacy and safety. Methods This registered report pres...

This randomized clinical trial compares the effects of 1-page fact sheets that adopt either an information-listing approach or a direct advice approach on management of low back pain to prepare patien...

We are beyond delighted that the ENTRUST-PE framework has been endorsed by the Editors in Chief of 15 International Pain and Anaesthesiology journals. Those editors are copublishing, across the journa...

An abstract is unavailable.

The aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks...

Objective To investigate the impact of retracted trials on the production and use of healthcare evidence in the evidence ecosystem. Design Retrospective cohort study based on forward citation searchi...

This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...

German drugmaker Grünenthal pushed its latest opioid as a safer option. People around the world got hooked. Madlen Davies, Hristio Boytchev, and Rafael Cabrera report.

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Scientists launch a new research center to study what they say is now a leading disease risk factor: corporations.

Relying on published data alone might be insufficient for meta-analyses to be reliable and trustworthy since selective outcome reporting is common, especially for adverse events. We investigated the e...

This webinar is being produced by the International Association for the Study of Pain's Methodology, Evidence Synthesis, and...

Two-year collaboration aims to create tools to help counter the tide of flawed research.

By Carey Gillam People diagnosed with infertility and certain cancers may have to blame the very air they breathe, according to a new report that adds to evidence that tiny plastic particles in air p...

This systematic review and network meta-analysis evaluates the efficacy associated with conventional and novel spinal cord stimulation therapies compared with conventional medical management.

The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing,…