Representing scientists nationwide who collaboratively research, diagnose, and treat pain in the United States.

Chronic pain and mental health conditions are often conceptualised and communicated to young people, and others, as totally separate entities. Taken together however, ‘one plus one does not equal…

Pain is the hallmark symptom of claudication, the early stage of peripheral artery disease (PAD), yet its relationship with psychological distress remains unclear. We described pain patterns and…

The Global Perceived Effect (GPE) scale is widely used to evaluate perceived improvement in individuals with low back pain (LBP). However, factors that influence GPE ratings by patients and…

Negative interpretation bias, the tendency to interpret ambiguous information in a threatening way, is thought to play an important role in the experience and maintenance of chronic pain. However,…

Greater caregiver protectiveness is often associated with poorer outcomes in children and adolescents with pain. However, there is a lack of understanding about the specific contexts of where…

Emerging research indicates the potential of psychological pain management programs to address disability and distress associated with endometriosis-related pain. Understanding the characteristics of…

Chronic pain affects millions of people in the United States (U.S.), with Latinx individuals facing higher risks due to chronic illness, manual labor jobs, and limited access to healthcare and…

Well-intentioned policies to reduce opioid prescribing can conflict with efforts to manage advanced cancer pain, resulting in structural barriers to opioid pain management that complicate the…

Among persons with High Impact Chronic Pain (HICP), we assessed the impact of cognitive behaviorally-based self-management interventions on sustained HICP and on favorable chronic pain outcomes (mild…

Central post-stroke pain (CPSP) of thalamic origin is one of the most frequent subtypes in all kinds of CPSP, and often be refractory to treatments and affect the long-term prognosis of thalamic…

Neuroinflammation influences the development of chronic pain, an increasingly prevalent condition impacting the lives of many worldwide. Given the challenges of managing chronic pain, it is essential…

Objectively measuring pain in laboratory animals is essential for pain research and analgesic development. Despite the development of various behavioral tests to measure evoked pain in animal models,…

Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory and immune mechanisms are activated following TSE, play a role in the transition from acute…

Visceral pain remains a major clinical challenge, often resistant to conventional analgesics. Sigma-1 receptor (σ1R) antagonists enhance opioid antinociception in somatic and neuropathic pain, yet…

Chronic pain affects approximately 20% of adults worldwide and is a leading cause of disability. Emerging evidence suggest that nutrition may influence pain perception. However, the association…

The co-occurrence of chronic pain and trauma symptoms is prevalent; thus treatment approaches that address both are required. This systematic review of non-randomized studies aims to describe…

High-frequency stimulation (HFS) is a human surrogate model of secondary hyperalgesia and a key experimental tool for understanding the mechanisms and modulation of central nociceptive pathways. An…

This cross-sectional study examined whether individualized racism, as measured by experiences of discrimination, internalized stigma of chronic pain, and perceived injustice, as well as structural…

Poor sleep and pain are common in rheumatoid arthritis (RA). This study sought to understand the temporal relationships between multidimensional sleep and pain in daily life among individuals with…

Pediatric post-surgical pain is common and associated with diminished quality of life and significant medical costs. While quantitative sensory testing (QST) is a promising tool for predicting…

Traumatic injuries from road traffic crashes are a major global health concern, resulting in significant physical, emotional, and social consequences, with pain being a frequent outcome. Chronic pain…

This secondary analysis of a randomized controlled trial investigated whether baseline clinical characteristics moderate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and motor…

This secondary analysis of a randomized controlled trial investigated whether baseline clinical characteristics moderate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and motor…

Understanding pain and pain management in the construction workforce is critical due to the physically demanding nature of their work. This study aimed to describe pain and quality of life among…

Intense injury induces long-term changes in the spinal nociceptive system, which increases pain in magnitude and duration. We investigated whether activation of G protein-coupled receptor 37 (GPR37)…

Dental surgeries are among the most common outpatient procedures, yet the temporal aspects of pain resolution and the relation to longer term pain outcomes remains poorly understood. Furthermore, the…

Behavioral depression is a cardinal sign of clinically relevant pain and a target of pain treatment. Accordingly, preclinical assays of pain-depressed behavior can serve as tools for translational…

Chronic low back pain (CLBP) is prevalent. Understanding its progression and identifying related predictors is essential to guide its management. This study aimed to characterize CLBP trajectories…

Given chronic pain remains a major public health concern and focus of national prevention and management objectives, this study examined temporal trends, a complementary prevalence-burden framework,…

The clinical efficacy of opioid-based therapies is severely limited by the emergence of maladaptive neuroplasticity which drives both analgesic tolerance and paradoxical pain sensitization. Although…

Children with painful disorders of gut brain interaction (DGBIs) report stigmatization from medical providers, school personnel, family members, and peers. The consequences of pain-related stigma…

Chronic pain is common and burdensome among people with end stage kidney disease (ESKD). Pain management options are limited and prescription opioids are often used in this population, but carry…

Despite guideline recommendations to the contrary, patients experiencing low back pain are commonly exposed to low-value care. Spinal injections for chronic low back pain are a key example of this…

Musculoskeletal pain costs over $100 billion annually in the U.S., severely impacting daily life, especially chronic low back pain. Disparities in prevalence and management, particularly for…

Chronic ocular pain (COP) defines any type of pain in the eye persisting for more than 3 months and is often accompanied by symptoms that extend beyond the ocular system, including central nervous…

Despite evidence that racial and ethnic minoritized groups experience greater pain burden and poorer treatment outcomes, Asian Americans (AAs)—one of the fastest-growing U.S. populations—remain…

Chronic pain (CP) that significantly impacts a person's life, known as high impact chronic pain (HICP), is an important measure of CP consequences. The aims of this study were to propose EuroQol 5…

Pain is an unpleasant experience regulated by endogenous mechanisms. Conditioned pain modulation is a particularly well-studied inhibitory mechanism in which continuous painful stimuli (2 min) are…

This natural experiment study examined associations between system-wide telehealth implementation and pain psychology service utilization and socioeconomic disparities among patients with chronic…

Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity, impaired epithelial barrier function, and autonomic dysregulation, and has a higher prevalence in women. Most preclinical…

Chronic pain is a subjective experience, and the absence of objective medical evidence can contribute to stigma. Despite being classified as a disease in the ICD-11 and research findings showing…

Affective, cognitive, and behavioral factors contribute to pain persistence and disability. Cognitive-behavioral therapy (CBT) is known to be useful in chronic pain treatment. Clinical trials of CBT…

Cervical radiculopathy (CR) is a neuropathic condition characterized by heterogeneous clinical presentations affecting musculoskeletal, neurological, and psychological domains. The variable success…

Prior studies report association between elevated C-reactive protein (CRP), low vitamin D and development of chronic musculoskeletal pain. However, these small studies did not consider relevant and…

Prior research has established a bidirectional relationship between sleep and pain, yet this relationship remains understudied in people living with HIV (PLWH). The current cross-sectional study…