To examine the barriers and enablers to integrating evidence-based deprescribing recommendations into clinical practice guidelines.

To identify the reporting characteristics and recommended design features of mapping reviews for public health decision-makers.

Comparative evaluations of machine learning (ML) and logistic regression (LR) for clinical prediction frequently report ML as superior, but the methodological framework producing those comparisons has...

The growing use of the term “real-world evidence” (RWE) has introduced a classification of clinical research based on its perceived proximity to routine practice rather than its methodological charact...

Within a meta-analytic framework, validating surrogate endpoints traditionally requires individual patient data (IPD) from multiple randomized controlled trials (RCTs). This is rarely feasible in rare...

As individuals concerned with ethics in science, medicine, and public health, we wish to express our dismay at the approach taken by Senate leaders to

Diagnostic accuracy studies that compare two or more index tests (comparative diagnostic accuracy studies) can be at risk of generating biased results due to shortcomings in the statistical analysis. ...

Recent studies have raised concerns arising from the exploitation (“mining”) of public health databases for low-quality, mass-produced papers. However, it remains challenging to disambiguate whether s...

An Act to make provision to require Ministers of the Crown and others when making strategic decisions about the exercise of their functions to have regard to the desirability of reducing socio-economi...

The Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group is developing GRADErater (GRADE Rating Automation Through Enhanced Reasoning), an official, automated tool f...

Key tasks in the development of guideline recommendations include determining the magnitude of desirable and undesirable health effects, the overall net effect and assessing the certainty of evidence....

As riots spread across Belfast, Tommy Robinson promoted a movement founded by a sanctioned Russian oligarch, which has pushed white supremacist propaganda about the death of Henry Nowak

Somali referee Omar Artan says he was subjected to an 11-hour immigration interview before being denied entry to the United States for the World Cup despite holding the "right papers" and "right visa"...

Most people want a fairer society, a working democracy, a protected planet. So why split the vote & let the far-right in to destroy it all? That's why I've signed this open letter urging progressive l...

Clinical prediction models that estimate an individual’s outcome risk are often evaluated using discrimination metrics, particularly the area under the receiver-operating characteristic curve (AUROC; ...

Expert panels in diagnostic accuracy research typically classify the target condition dichotomously (i.e. present or absent) for each study participant. This may however lead to biased accuracy estima...

Linked administrative data covering whole populations are fundamental resources for longitudinal studies of children with rare conditions (cases) and unaffected peers (comparators). Data minimisation ...

Many people with diabetes do not consistently receive guideline-recommended preventative foot care, increasing their risk for severe ulcers and amputations. Most people who undergo a lower-extremity a...

The capture of patient baseline characteristics in randomized controlled trials (RCTs) is essential for assessing external validity and for exploring treatment effect heterogeneity. Yet, the capture o...

Temporal trends in exposure are a common source of bias in the case-crossover design. We evaluated four different estimators of the exposure odds ratio (OR) that adjust for such trends.

People with lived experience are increasingly involved in guideline development. There is limited research about the experiences of lived experience engagement in guideline development from the perspe...

Exclusive: Clinical guidelines should change to avoid exposing young people to potentially harmful side-effects, researchers say

With the exponential growth of biomedical literature, the challenge of conducting systematic reviews is becoming increasingly burdensome. We aimed to evaluate the performance of large language models ...

It is becoming ever clearer both how devastating the second wave of winter 2020/21 was, and how much of that devastation could have been avoided.

Channel 4’s new series about sewage in our rivers and beaches will rightly make people angry. But it fails to recognise that things have changed already.

Randomized controlled trials (RCTs) are more likely to be included in evidence syntheses of health interventions due to their methodological rigor. However, the integration of nonrandomized studies (N...

The Journal of Clinical Epidemiology takes a broad approach to the evidence ecosystem. In any given issue, metaresearch topics focused on primary studies, evidence synthesis, and guidelines can be fou...

As the keepers of the editorial “front door” of the journal, we are profoundly aware of the myriad challenges and some opportunities that accompany the ubiquitous rise of artificial intelligence (AI) ...

This study tested the effect of questionnaire structure on response, speed of return, and content of answers in a postal survey. All 259 patients aged 30-59 years who consulted with back pain at four ...

While data sharing holds great potential to maximize the value of research and reduce waste, these benefits can only be fully realized if shared data are also effectively reused. Yet data reuse remain...

To support systematic reviewers new to network meta-analysis (NMA), we (i) identified and described published methods resources for conducting systematic reviews (SRs) with NMA of randomized controlle...

To identify, summarise, and analyse published comments relevant to the PRISMA-P (Preferred Items for Reporting Systematic reviews and Meta-Analyses Protocols) 2015 reporting guideline for systematic r...

The prioritization of clinical practice guideline (CPG) efforts is particularly challenging for rare genetic neurodevelopmental disorders given the large number of (ultra)rare conditions and limited r...

Drafting the monthly round-up of noteworthy manuscripts to be published in the corresponding issue of the Journal of Clinical Epidemiology (JCE) is both a privilege and pleasure. The task includes rer...

Historically, local progression, an outcome of effectiveness in curative radiotherapy, has not always been statistically analyzed with the same method. This article aims to elucidate the validity and ...

Completeness of follow-up is a crucial aspect of data quality in cohort studies and clinical trials. This study aims to provide an overview of different methods to calculate follow-up completeness. Ad...