iiinova — where your digital self keeps evolving

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Michael Le Page @mjflepage.bsky.social · 01/05/2026

And his company did fail. The public Human Genome Project mapped the human genome first to help it assemble the pieces. Venter tried to beat them by skipping the mapping part but it didn't work and he ended up relying on HGP's map to assemble his version of the genome

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Pedro Beltrao @pedrobeltrao.bsky.social · 24/04/2026

It looks like Anthropic has included fake paper generation in their model alignment considerations and Claude tries to avoid doing it. Maybe we need to make more noise about this in general to get the others model developers onboard with this.

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John FitzGiraffe Kennedy @jgiraffekennedy.bsky.social · 17/04/2026

2. The Slow Path: Go slow, verify everything, achieve frustration This is the “responsible adult” mode. The engineer tries to: - read every line - reconstruct intent - validate assumptions - check invariants - write tests the model should have written - rewrite, refactor, and fix all things (6)

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Elena Nicolay @enicolay.bsky.social · 18/03/2026

I have a joke about poor data management, but it's not FAIR.

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Mathurin Dorel @mathsrish.bsky.social · 13/02/2026

Wait, so ONT demonstrated that they solved protein nanopore sequencing, including three PTMs, on peptides with a few zeptomolar accuracy (1e-21 !, 6 molecules/mL) almost a year ago (finally catching up London calling 2025) and no-one made a big deal out of it ?? This is actually insane.

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Mathurin Dorel @mathsrish.bsky.social · 04/02/2026

Very interesting read, making the important distinction between software dev and data analysis workflows. Data analysis is more iterative than software dev because you mostly don't know what the final state of the analysis should look. Iteration is key. Will definitely try the positron databot.

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Mathurin Dorel @mathsrish.bsky.social · 02/02/2026

Did some of the perpetrator's name fail to be redacted as well or did the DOJ work with proper diligence for those ?

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Natasha Loder @natashaloder.bsky.social · 20/01/2026

EXCLUSIVE: A quiet revolution happened at Great Ormond Street Hospital last week. A girl with a rare fatal condition received a custom drug under a new MHRA protcol that is 1st step towards process approval, a shift that could one day save millions of lives. www.economist.com/science-and-...

economist.com

Treatment of a teenager with an ultra-rare condition is a medical milestone

It will change regulators’ rule books

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Jon Cooper @joncooper-us.bsky.social · 07/01/2026

👇👇👇👇

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lauren @lauren.rotatingsandwiches.com · 31/12/2025

good piece with an incidental insanely brutal takedown of klein

The media has spent the last few months trying to make sense out of nonsense, attempting to conjure motive, manifesto, and meaning out of the dumbest shit scrawled onto bullets. These were sad attempts to impose meaning on an increasingly incoherent world by a literati that has not yet accepted its irrelevance in a postliterate society. But the most humiliating display of literate obliviousness in the face of the total collapse of meaning, however, was Ezra Klein's bizarre eulogy to Charlie Kirk. The now-infamous column ("Charlie Kirk Was Practicing Politics the Right Way") can best be understood as an expression of class solidarity. Klein, I would argue, sees both himself and Kirk as being Debate Guys, wordcels who engage in the marketplace of ideas and let speech sort itself out into political action.

Kirk did not commit violence, not because he abhorred it, but because committing violence was someone else's job. Last year, he called for using whips against migrants, saying, "Of course you should be able to use whips against foreigners that are coming into your country. Why is that controversial?" In early June of this year, as the president deployed troops to Los Angeles, Kirk publicly advocated for invoking the Insurrection Act of 1807 to crush the immigration protests. And in August, he called for "federalizing" the district of Columbia, saying,
"Roll in the tanks, bring in the military."
With his close relationship to the commander in chief of the United States of America, Charlie Kirk was no mere talker, idea-peddler, or purveyor of discourse. He built an empire on legitimizing violence and harvesting the enthusiasm and glee around it. Even before his death became a pretext to enact violence on American cities, he had already substantively shaped history. Charlie Kirk was a part of the real world in a way that Ezra Klein will never be.

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Mathurin Dorel @mathsrish.bsky.social · 20/12/2025

Anyone with non existing reference in their paper should get publicly named and shamed, and barked from any scientific role forever. The continuity of knowledge is too important, we have to be able to trace the source of scientific claims.

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Isabel @isabelott.bsky.social · 20/12/2025

Our job is to engage with, build upon, & further the academic literature! If you don’t take that responsibility seriously, feel free to find a better-paying job that you’ll be better at.

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Randall Munroe @xkcd.com · 14/11/2025

Car Size xkcd.com/3167/

4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: It’s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I don’t get the biggest one, I’m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I don’t install more whirling spike clubs, I’ll be destroyed by all the other drivers who...

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Derek Powazek @fraying.bsky.social · 10/09/2025

You are under no obligation to mourn the death of people who would’ve celebrated yours.

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Mathurin Dorel @mathsrish.bsky.social · 08/09/2025

Anyone knows more about the new Russian cancer vaccine ? The most reliable info I could find in English is that it's 4 viruses. The new press releases also sound like the full treatment involves personalized mRNA and that it was tested in 48 patients with 100% success new.nmicr.ru/en/pacientam...

new.nmicr.ru

Cancer Vaccine - biotech solutions in the fight against cancer diseases

Oncolytic and personalized vaccines - clinical trials and patient enrollment for Phase I begins as early as late 2024, early 2025

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Mathurin Dorel @mathsrish.bsky.social · 21/08/2025

Yeah, LLM suck at data retrieval... (Tried to be lazy today)

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laydgeur @laydgeur.bsky.social · 15/08/2025

Je m’arrête là dessus un instant, car je vois souvent cette étude citée pour dire qu’en gros le recours à la clim augmenterait systématiquement la température de la ville de 2 à 3°C et que c’est bien la preuve que c’est pas une solution. Ce qui est complètement partiel et trompeur.

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George Takei @georgetakei.bsky.social · 08/08/2025

No, you did not give those of us who happened to look like the people who bombed Pearl Harbor any due process. And that was profoundly wrong. It destroyed our lives.

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Mathurin Dorel @mathsrish.bsky.social · 09/08/2025

Great model for both science and the journals viability. Everyone just need to convince philanthropists to fund their favorite journals and everybody wins.

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Mark A. Hanson @hansonmark.bsky.social · 04/08/2025

If I could change one thing about #ScientificPublishing I'd ask funding bodies to stipulate all work they fund be published in non-profit journals. The knock-on effects would alleviate most of the strain on #AcademicSky. This isn't hard. It's big, but actually, it's pretty easy. 1/n

direct.mit.edu

The strain on scientific publishing

Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

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Mathurin Dorel @mathsrish.bsky.social · 10/07/2025

But if falls to less than 5% in winter, when Europe needs the most electricity. Notice on the left graph how wind, *gas* and *coal* take over. Europe needs to scale up nuclear and batteries big time, for the climate and for it's energy independence. (Hydro scale up is not possible sadly).

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CNRS Ile-de-France Villejuif @cnrs-idf-villejuif.bsky.social · 23/06/2025

La #ScienceTailleXXelles revient en lle-de-France ! 🤩 Nos 21 nouvelles ambassadrices sont mécatronicienne, archéobotaniste, exobiologiste, ou encore informaticienne👩‍🔬 Chercheuses, doctorantes, ingénieures et techniciennes, toutes ont à cœur de montrer que la science se conjugue aussi au féminin ! ⤵️

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Mathurin Dorel @mathsrish.bsky.social · 02/07/2025

Nice thing about having a thermal camera on your phone is that you can quantify your suffering during a heat wave. You can also check if your insulation measures are working and how much worse it could get which is nice I guess.

Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.

Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.

Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.

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European Research Council (ERC) @erc.europa.eu · 30/06/2025

On the final day of Poland’s EU Presidency, 🇵🇱 Deputy Minister for Science ‪Andrzej Szeptycki @szeptycki.bsky.social ‬argues that Europe’s global standing depends on stronger investment in research and innovation. 🧠 “Strategic sovereignty starts with research” Read the piece 👉 europa.eu/!6BkvPj

europa.eu

Europe’s path to competitiveness: The strategic role of research and innovation

By Andrzej Szeptycki

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Johannes Hohlbein @hohlbeinlab.bsky.social · 30/06/2025

Good read. My fav: "If I could distill my scientific life into five words, they would read: “I regret to inform you”"... www.embopress.org/doi/full/10....

embopress.org

A career in science requires a thick skin | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Jen Christiansen @jenchristiansen.com · 25/06/2025

Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪

scientificamerican.com

Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science

These graphics will guide you through science-based vaccine guidelines for children and adults

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Mathurin Dorel @mathsrish.bsky.social · 18/06/2025

You regular reminder that European science does not lack ideas, it lacks fundings.

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Benoit Bruneau @benoitbruneau.bsky.social · 15/06/2025

Weizmann Institute rn

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Claus Wilke @clauswilke.com · 10/06/2025

I also reject the notion that "most biomedical literature is unreliable/untrue." This is simply not the case. The vast majority of biomedical research is so reliable we don't even think about it. And yes, some studies and even subfields have issues, but let's acknowledge all the things that work. 🧵

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Ted Underwood @tedunderwood.com · 07/06/2025

It’s becoming clearer and clearer that universities have to produce their own open models. If we can’t pull that off, we may continue to provide cafeterias and climbing walls — but the key decisions about learning will take place elsewhere.

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Mathurin Dorel @mathsrish.bsky.social · 02/06/2025

Seems I'm exhausting my jinx this week (technically last week). In one back and forth trip I'm getting enough flights cancelled to make a thread about it.

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Mathurin Dorel @mathsrish.bsky.social · 02/06/2025

As I just visited CERN I have to oppose this statement. But EMBO is a very good second ^^ And I say it as a biologist who regularly interacts with EMBO. (Also personally I choose Geneva over Heidelberg any day 😍)

Artwork at CERN: the entertwined metal ribbons engraved with landmark contribution to physics.
On the top salient edge of the ribbon "2012 CERN: Higgs boson" is at the forefront of the picture.

Landscape photograph from the bridge of CERN's museum encompassing the tram, a few cars, the flags of CERN contributing nations, and in the background the "Haut Jura".

Landscape picture of the Geneva lake and the Alps taken from the Jura chain near La Dôle. Geneva and it's iconic "Jet d'eau" is visible on the right of the picture.

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Institute of Molecular Genetics @imgprague.bsky.social · 18/02/2025

🚀We are very pleased to announce that Prof. David Staněk became a member of the European Molecular Biology Organization @embo.org 👏David considers EMBO as "the best thing that European countries have done for science."

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Hank Green @hankgreen.bsky.social · 29/05/2025

200+ scientists are in the middle of a marathon livestream to show why weather and climate science is so important and needs all our help to continue. It is here: wclivestream.com/watch

wclivestream.com

Redirecting to: https://www.youtube.com/@wclivestream/live

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Melaine Le Roy @subfossilguy.bsky.social · 28/05/2025

INCREDIBLE !! Here we are... 😱😱😱 After days of overloading and cracks propagating, Birch Glacier collapsed today at 3.24 pm over Blatten and the dammed Lonza river... Devastating! 😭 www.letemps.ch/suisse/valai...

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Mathurin Dorel @mathsrish.bsky.social · 27/05/2025

I need to vent: the most stupid thing we are imposed by air carriers is that they will not wait 2 minutes for you in case of slightly delayed correspondence even when a bus drives to the airplane. Either you win the sprint (which seniors just cannot) or the bus and flight leave without you.

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/05/2025

Lux Capital providing funding opportunities for academic biomedical research aligned with interests 👏 www.luxcapital.com/news/our-hel...

luxcapital.com

Our Helpline for American Scientists

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Denis Wirtz @deniswirtz.bsky.social · 07/05/2025

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free: research.jhu.edu/rdt/funding-...

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Mathurin Dorel @mathsrish.bsky.social · 06/05/2025

So today 18 morons decided their selfish little beef with Mertz justified blocking a coalition-agreed chancellor. Germans (internal) compromise culture has been stabbed and it's gonna take a lot of healing.

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derek guy @dieworkwear.bsky.social · 29/04/2025

personally would like to see every store show what part of the price increase is due to tariffs bc if these tariffs ever come down, i need to see that price go right back down

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Florian Trigodet @floriantrigodet.bsky.social · 28/04/2025

Our pangenomes were certainly raising some red flags. But we were not sure if fractions of genomes as circular elements were a feature of nature that we missed due to the years of short-read assemblies. With changing technology, you sometimes learn things you didn't even know you were missing.

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Thomas @thomasthefrench.eurosky.social · 29/04/2025

#spain #blackout As you know I'm talking a lot about the electricity and electricity grid (ok a bit less recently) So I can explain to you what happened: we don't know.

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Jessica Ellis @baddestmamajama.bsky.social · 23/04/2025

Always baffles me when someone said “I didn’t hear about that when I was a kid.” Of course you didn’t. You were a child. You hadn’t heard of most things. I didn’t know who Paul Newman was when I was a kid, that doesn’t mean he didn’t exist.

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Medlife Crisis (Rohin) @medcrisis.bsky.social · 23/04/2025

I was born in the 80s, and could truthfully say I had not heard of ADHD when I was a kid. Neither had my mum. But what I did hear about was being put in detention regularly, being suspended from school, being sent to see a psychologist due to my disruptive behaviour and inability to concentrate.

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