iiinova — where your digital self keeps evolving

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Michael Le Page @mjflepage.bsky.social · 01/05/2026

And his company did fail. The public Human Genome Project mapped the human genome first to help it assemble the pieces. Venter tried to beat them by skipping the mapping part but it didn't work and he ended up relying on HGP's map to assemble his version of the genome

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Pedro Beltrao @pedrobeltrao.bsky.social · 24/04/2026

It looks like Anthropic has included fake paper generation in their model alignment considerations and Claude tries to avoid doing it. Maybe we need to make more noise about this in general to get the others model developers onboard with this.

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Mathurin Dorel @mathsrish.bsky.social · 18/04/2026

Congratulation, you're officially a scientist now.

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John FitzGiraffe Kennedy @jgiraffekennedy.bsky.social · 17/04/2026

2. The Slow Path: Go slow, verify everything, achieve frustration This is the “responsible adult” mode. The engineer tries to: - read every line - reconstruct intent - validate assumptions - check invariants - write tests the model should have written - rewrite, refactor, and fix all things (6)

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Mathurin Dorel @mathsrish.bsky.social · 22/03/2026

Do they have it after infecting the fish with bacteria as well ?

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Elena Nicolay @enicolay.bsky.social · 18/03/2026

I have a joke about poor data management, but it's not FAIR.

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Mathurin Dorel @mathsrish.bsky.social · 18/03/2026

Elle peut aussi essayer de demander à un labo ou un incubateur. Genre le shaker (Génopole à Évry) ou biolabs par exemple.

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Mathurin Dorel @mathsrish.bsky.social · 13/02/2026

And now they are about to reach the pinnacle for biology with full length protein with PTMs. I see a future where every "mass spec" facility runs a Promethion and it is glorious.

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Mathurin Dorel @mathsrish.bsky.social · 13/02/2026

I would say it went to where we are today, but some ideas take longer to reach reality than others. I think ONT's strategy was and still is the correct one: start easy with DNA (stable, 4 letters to discriminate, massive application in diagnostic) and climb up the value chain.

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Mathurin Dorel @mathsrish.bsky.social · 13/02/2026

Wait, so ONT demonstrated that they solved protein nanopore sequencing, including three PTMs, on peptides with a few zeptomolar accuracy (1e-21 !, 6 molecules/mL) almost a year ago (finally catching up London calling 2025) and no-one made a big deal out of it ?? This is actually insane.

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Mathurin Dorel @mathsrish.bsky.social · 04/02/2026

Very interesting read, making the important distinction between software dev and data analysis workflows. Data analysis is more iterative than software dev because you mostly don't know what the final state of the analysis should look. Iteration is key. Will definitely try the positron databot.

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Mathurin Dorel @mathsrish.bsky.social · 02/02/2026

Did some of the perpetrator's name fail to be redacted as well or did the DOJ work with proper diligence for those ?

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Natasha Loder @natashaloder.bsky.social · 20/01/2026

EXCLUSIVE: A quiet revolution happened at Great Ormond Street Hospital last week. A girl with a rare fatal condition received a custom drug under a new MHRA protcol that is 1st step towards process approval, a shift that could one day save millions of lives. www.economist.com/science-and-...

economist.com

Treatment of a teenager with an ultra-rare condition is a medical milestone

It will change regulators’ rule books

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Jon Cooper @joncooper-us.bsky.social · 07/01/2026

👇👇👇👇

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lauren @lauren.rotatingsandwiches.com · 31/12/2025

good piece with an incidental insanely brutal takedown of klein

The media has spent the last few months trying to make sense out of nonsense, attempting to conjure motive, manifesto, and meaning out of the dumbest shit scrawled onto bullets. These were sad attempts to impose meaning on an increasingly incoherent world by a literati that has not yet accepted its irrelevance in a postliterate society. But the most humiliating display of literate obliviousness in the face of the total collapse of meaning, however, was Ezra Klein's bizarre eulogy to Charlie Kirk. The now-infamous column ("Charlie Kirk Was Practicing Politics the Right Way") can best be understood as an expression of class solidarity. Klein, I would argue, sees both himself and Kirk as being Debate Guys, wordcels who engage in the marketplace of ideas and let speech sort itself out into political action.

Kirk did not commit violence, not because he abhorred it, but because committing violence was someone else's job. Last year, he called for using whips against migrants, saying, "Of course you should be able to use whips against foreigners that are coming into your country. Why is that controversial?" In early June of this year, as the president deployed troops to Los Angeles, Kirk publicly advocated for invoking the Insurrection Act of 1807 to crush the immigration protests. And in August, he called for "federalizing" the district of Columbia, saying,
"Roll in the tanks, bring in the military."
With his close relationship to the commander in chief of the United States of America, Charlie Kirk was no mere talker, idea-peddler, or purveyor of discourse. He built an empire on legitimizing violence and harvesting the enthusiasm and glee around it. Even before his death became a pretext to enact violence on American cities, he had already substantively shaped history. Charlie Kirk was a part of the real world in a way that Ezra Klein will never be.

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Mathurin Dorel @mathsrish.bsky.social · 20/12/2025

Anyone with non existing reference in their paper should get publicly named and shamed, and barked from any scientific role forever. The continuity of knowledge is too important, we have to be able to trace the source of scientific claims.

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Isabel @isabelott.bsky.social · 20/12/2025

Our job is to engage with, build upon, & further the academic literature! If you don’t take that responsibility seriously, feel free to find a better-paying job that you’ll be better at.

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Randall Munroe @xkcd.com · 14/11/2025

Car Size xkcd.com/3167/

4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: It’s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I don’t get the biggest one, I’m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I don’t install more whirling spike clubs, I’ll be destroyed by all the other drivers who...

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Derek Powazek @fraying.bsky.social · 10/09/2025

You are under no obligation to mourn the death of people who would’ve celebrated yours.

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Mathurin Dorel @mathsrish.bsky.social · 08/09/2025

It's not totally impossible with everything they throw at the cancer and the Russians' expertise in virology. I'm curious about the side effects though, no way they could dose every cancer patients repeatedly with 4 viruses. Then comes the question of patient inclusion and mRNA manufacturing.

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Mathurin Dorel @mathsrish.bsky.social · 08/09/2025

Anyone knows more about the new Russian cancer vaccine ? The most reliable info I could find in English is that it's 4 viruses. The new press releases also sound like the full treatment involves personalized mRNA and that it was tested in 48 patients with 100% success new.nmicr.ru/en/pacientam...

new.nmicr.ru

Cancer Vaccine - biotech solutions in the fight against cancer diseases

Oncolytic and personalized vaccines - clinical trials and patient enrollment for Phase I begins as early as late 2024, early 2025

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Mathurin Dorel @mathsrish.bsky.social · 21/08/2025

Yeah, LLM suck at data retrieval... (Tried to be lazy today)

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Mathurin Dorel @mathsrish.bsky.social · 18/08/2025

Please delete. This lazy AI crap should not be encouraged. This dumbass could not even be bothered with getting actual pictures of all European leaders for this collage when then each have dozens of official portraits.

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laydgeur @laydgeur.bsky.social · 15/08/2025

Je m’arrête là dessus un instant, car je vois souvent cette étude citée pour dire qu’en gros le recours à la clim augmenterait systématiquement la température de la ville de 2 à 3°C et que c’est bien la preuve que c’est pas une solution. Ce qui est complètement partiel et trompeur.

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George Takei @georgetakei.bsky.social · 08/08/2025

No, you did not give those of us who happened to look like the people who bombed Pearl Harbor any due process. And that was profoundly wrong. It destroyed our lives.

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Mathurin Dorel @mathsrish.bsky.social · 09/08/2025

Great model for both science and the journals viability. Everyone just need to convince philanthropists to fund their favorite journals and everybody wins.

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Mark A. Hanson @hansonmark.bsky.social · 04/08/2025

If I could change one thing about #ScientificPublishing I'd ask funding bodies to stipulate all work they fund be published in non-profit journals. The knock-on effects would alleviate most of the strain on #AcademicSky. This isn't hard. It's big, but actually, it's pretty easy. 1/n

direct.mit.edu

The strain on scientific publishing

Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

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Mathurin Dorel @mathsrish.bsky.social · 18/07/2025

For Europe at least. USA, Canada and Asia seem better represented at www.higheredjobs.com/international/ and www.higheredjobs.com/international/ But basically looking for "academic job board" should provide the outcome you're looking for.

higheredjobs.com

International Positions - HigherEdJobs

Jobs in higher education. Faculty and administrative positions at colleges and universities. Updated daily. Free to job seekers.

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Mathurin Dorel @mathsrish.bsky.social · 18/07/2025

Notions is great for organisational data aggregation but it's too heavy for note taking. Great for collaboration though, and you can easily copy-paste the important notes from obsidian.

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Mathurin Dorel @mathsrish.bsky.social · 18/07/2025

Obsidians is great for simple formatted text with links. The simplicity and lightness makes it perfect to take note on the phone. I use it for all my notes now and I've come back to them multiple times thanks to the search function. Tags are great to link topics years appart. And I love the graph.

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Mathurin Dorel @mathsrish.bsky.social · 18/07/2025

Starter packs are not the right tools for that, too centralized and not flexible enough. This should be a community actualized website, or a smart webscrapper that tracks where it finds offers and removes them when they're gone.

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Mathurin Dorel @mathsrish.bsky.social · 10/07/2025

Solar is great to power AC during heat waves when managed efficiently (and there also batteries would help). For everything else it's trash that jiggles electrons when they don't need jiggling and needs to be curtained because it's not economically viable. Cheap to install but worthless production.

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Mathurin Dorel @mathsrish.bsky.social · 10/07/2025

But if falls to less than 5% in winter, when Europe needs the most electricity. Notice on the left graph how wind, *gas* and *coal* take over. Europe needs to scale up nuclear and batteries big time, for the climate and for it's energy independence. (Hydro scale up is not possible sadly).

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CNRS Ile-de-France Villejuif @cnrs-idf-villejuif.bsky.social · 23/06/2025

La #ScienceTailleXXelles revient en lle-de-France ! 🤩 Nos 21 nouvelles ambassadrices sont mécatronicienne, archéobotaniste, exobiologiste, ou encore informaticienne👩‍🔬 Chercheuses, doctorantes, ingénieures et techniciennes, toutes ont à cœur de montrer que la science se conjugue aussi au féminin ! ⤵️

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Mathurin Dorel @mathsrish.bsky.social · 02/07/2025

Nice thing about having a thermal camera on your phone is that you can quantify your suffering during a heat wave. You can also check if your insulation measures are working and how much worse it could get which is nice I guess.

Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.

Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.

Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

If you have staff for it, I would track the president or the head of HR down and ask them personally. Technically whoever you hired on this project should now qualify as a "US scientific refuge".

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

Aah, got it. It was a collaborative project right? Administratively you can't do it alone so there would be no sense in providing the funding (practically we know it's different). Unless you already hired someone I would just reapply for a similar project since it's not funded anymore.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

Europe has the minds to be a global scientific power, but it needs to provide the infrastructures and fundings to enable their expression.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

"The call for a substantial boost in financial resources is a central tenet of the Warsaw Declaration, adopted in March 2025." Yes! And make it billions. Anything short of doubling the ERC budget would be insufficient. Member states also need to increase their national funding.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

"the mid-term evaluation of Horizon Europe, conducted under the Polish Presidency of the EU Council, highlighted several areas in need of improvement. These include the necessity for better coordination, simpler administrative procedures, and, crucially, increased funding."

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European Research Council (ERC) @erc.europa.eu · 30/06/2025

On the final day of Poland’s EU Presidency, 🇵🇱 Deputy Minister for Science ‪Andrzej Szeptycki @szeptycki.bsky.social ‬argues that Europe’s global standing depends on stronger investment in research and innovation. 🧠 “Strategic sovereignty starts with research” Read the piece 👉 europa.eu/!6BkvPj

europa.eu

Europe’s path to competitiveness: The strategic role of research and innovation

By Andrzej Szeptycki

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Johannes Hohlbein @hohlbeinlab.bsky.social · 30/06/2025

Good read. My fav: "If I could distill my scientific life into five words, they would read: “I regret to inform you”"... www.embopress.org/doi/full/10....

embopress.org

A career in science requires a thick skin | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

Europe never lacked ideas, but since the 1970s it lacks funding. We're still more than happy to rescue our American colleagues but don't over ask. Our politicians are unfortunately not up to the task to replace the loss of US funding. Not the admin's fault.

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Mathurin Dorel @mathsrish.bsky.social · 30/06/2025

Well, it's Europe. You'll get a position while you would have been fired in the US. But we have a way more competitive funding environment and it's only fair that you have to compete for it. Half of the *excellent* proposals to the ERC were not funded this year.

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Jen Christiansen @jenchristiansen.com · 25/06/2025

Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪

scientificamerican.com

Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science

These graphics will guide you through science-based vaccine guidelines for children and adults

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