Sign in

Rui Gonçalo Martinho

@martinholab.bsky.social
552 followers 1.8K following 160 posts

Our AIM is to understand the way germ cells segregate from the soma and differentiate into functional gametes.

PostsRepliesMedia
Rui Gonçalo Martinho @martinholab.bsky.social · 15/12/2025
Any suggestion for a particularly good anti-H3K4me3 antibody for immunostaining in Drosophila? Lately we have been using AB8580 (rabbit) that works well (i need to double check the batch number), but it is a bit dirty (punctuated staining in cytoplasm). Thanks!!!!
010
Rui Gonçalo Martinho @martinholab.bsky.social · 09/12/2025
“Part of what happens with a lot of this stuff is it's sort of like being too early to the party," says Gustavson. "Because of their [Eastman Kodak's] research labs and innovative nature, they tended to create things that, were ahead of the curve, not behind it." www.bbc.com/future/artic...
bbc.com
A 'toaster with a lens': The story behind the first handheld digital camera
In 1975, a young engineer in the company that made Kodak film took the first picture on a handheld digital camera. Photography would never be the same again.
020
Rui Gonçalo Martinho @martinholab.bsky.social · 28/11/2025
Is there any Drosophila species known to naturally specify more than one oocyte per egg chamber? I’ve been looking through the literature but haven’t found any exceptions. Does an oddball species exist, or is the ‘one-oocyte-per-cyst’ rule truly universal across the genus?
020
Reposted by Rui Gonçalo Martinho
Jonathan Pettitt @genotripe.bsky.social · 28/11/2025
C. elegans researchers were early adopters of open science: "The development of common resources and the belief that research findings and mutant strains should be freely shared has propelled worm research to the forefront" www.pnas.org/doi/10.1073/...
pnas.org
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS
Experimental organisms such as the nematode Caenorhabditis elegans are fundamental to biological discovery. The success of C. elegans research has ...
12213
Reposted by Rui Gonçalo Martinho
Emilio Mármol Sánchez @marmole6.bsky.social · 14/11/2025
🦣🧬🦣🤯💥We are pleased to share our new paper about ancient RNA expression profiles from the Woolly Mammoth, now published in Cell @cellpress.bsky.social www.cell.com/cell/fulltex... If you want to know more, read the 🧵 below:
111142
Reposted by Rui Gonçalo Martinho
Piali Sengupta @senguptalab.bsky.social · 23/10/2025
TT faculty job opening in #Neuroscience! We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply academicjobsonline.org/ajo/jobs/30961
academicjobsonline.org
Brandeis University, Biology Department
Job #AJO30961, Assistant Professor in Biology and Neuroscience Program, Biology Department, Brandeis University, Waltham, Massachusetts, US
186101
Reposted by Rui Gonçalo Martinho
Janelia Research Campus @hhmijanelia.bsky.social · 23/07/2025
🪰 A new ‘Eyemap’ developed by a team led by Arthur Zhao & @michaelreiser.bsky.social reveals how visual information detected by the fly’s eye shows up in neurons deep in the brain. Remarkably, the eye’s shape determines how flies see motion.👁️ 🔗 hhmi.news/4kSZjou
410022
Rui Gonçalo Martinho @martinholab.bsky.social · 09/11/2025
Most migratory birds are gone but its still a gorgeous place do visit - Boquilobo Bog Natural Reserve.
010
Reposted by Rui Gonçalo Martinho
🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 22/10/2025
Not today, parasitic #wasps!✋🚫 #Stinkbugs use a fungus-carrying organ on their hind legs to coat their eggs in #fungi🍄🦵 This provides a physical defense against #parasitic wasp oviposition🛡️ www.science.org/doi/10.1126/...
0126
Reposted by Rui Gonçalo Martinho
Mark Peifer (He, him) @peiferlabunc.bsky.social · 06/10/2025
Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n jobs.utoronto.ca/job/Toronto-... jobs.utoronto.ca/job/Toronto-...
Full text in linksFull text in links
23734
Reposted by Rui Gonçalo Martinho
Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 02/10/2025
Are you interested in a PhD in the area of "Mechanisms of translational control during embryogenesis?" Apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
12415
Reposted by Rui Gonçalo Martinho
Ferwen @ferwen.bsky.social · 03/10/2025
#FossilFriday ‘Black Beauty’, one of the smallest-known specimens of Tyrannosaurus rex, displayed at The Royal Tyrell Museum in Calgary, Alberta. wp.me/p3ihHu-1MX
47623
Rui Gonçalo Martinho @martinholab.bsky.social · 30/09/2025
Quick Drosophila question: I’m planning to integrate a construct on the second chromosome but would like to avoid the attP40 landing site. Any suggestion for a good alternative attP site on chromosome II? It’s for a skeletal-muscle–related project. Thanks! 🙂 Rui
135
Rui Gonçalo Martinho @martinholab.bsky.social · 26/09/2025
www.cell.com/current-biol...
cell.com
Linear covariation between germline and somatic mutation rates across ciliates and mammals
Wang et al. estimate the somatic mutation rate in a ciliate, which contains germline and somatic genomes in the same cell. They discover a linear correlation between per-year germline and somatic muta...
120
Reposted by Rui Gonçalo Martinho
Current Biology @currentbiology.bsky.social · 22/09/2025
Our latest issue is out!👇 www.cell.com/current-biol... On the cover: Nautilus ≈ 🐙+🐚 (Maybe — like the Nautilus — our journal is a living fossil, believing in the interest and inspiration our readers might draw from the diversity of biological systems, questions and approaches we try to feature🙏 )
Nautiloids (pictured)—a lineage of ancient, externally shelled cephalopods—once dominated our oceans, but today, these living fossils are threatened and in need of protection from over-exploitation.
0417
Reposted by Rui Gonçalo Martinho
Maxim Greenberg @maxvcg.bsky.social · 15/09/2025
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
journals.plos.org
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
39135
Reposted by Rui Gonçalo Martinho
Remco Stam @rstam.bsky.social · 14/09/2025
Chart from last year... No big change in % of US applicants, or? . marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
122
Reposted by Rui Gonçalo Martinho
Institute of Molecular Biotechnology @imbavienna.bsky.social · 09/09/2025
📰 New paper alert! In a collaborative project with the lab of Clemens Plaschka at the IMP, the lab of Julius Brennecke has revealed how PIWI proteins kickstart transposon silencing in reproductive cells. The findings are published in Molecular Cell: www.sciencedirect.com/science/arti...
0229
Reposted by Rui Gonçalo Martinho
Nature Portfolio @natureportfolio.nature.com · 13/09/2025
Living organisms are assumed to produce same-species offspring. A study in Nature reports a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species. go.nature.com/3V68MP0 🧪
This is figure 2, which shows M. ibericus queens lay males from two different species.
33512
Reposted by Rui Gonçalo Martinho
Cameron Thrash @jcamthrash.bsky.social · 11/09/2025
Microtubules in Asgard archaea (h/t @lanzen.bsky.social) www.cell.com/cell/fulltex... #jcampubs
cell.com
Microtubules in Asgard archaea
Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.
13110
Rui Gonçalo Martinho @martinholab.bsky.social · 08/09/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Rapid protamine evolution suppresses meiotic drive in Drosophila
Many animal species replace histones with protamines during spermatogenesis. Despite their importance for sperm function, protamines rapidly evolve in many species; the biological causes behind their ...
010
Reposted by Rui Gonçalo Martinho
Phil Plait @philplait.bsky.social · 07/09/2025
I hope everyone on the other side of the Earth is enjoying the total lunar eclipse! Except for flat Earthers.
An image of the full Moon with a thick, fuzzy black line across the middle. The caption says, "Flat Earth eclipses are awesome".
1531942
Reposted by Rui Gonçalo Martinho
paveltomancak.bsky.social @paveltomancak.bsky.social · 07/09/2025
Yesterday me and my lab celebrated #20years @mpi-cbg.de. There is a lot to say about that but the pictures from the event tell it better. Thanks city of #Dresden for the nice fireworks. That was unexpected. 10 more years or so? #LoPaTs 💕
711414
Rui Gonçalo Martinho @martinholab.bsky.social · 04/09/2025
www.nature.com/articles/d41...
nature.com
Flies evolved a shock-absorber tissue used during embryonic development
The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.
020
Reposted by Rui Gonçalo Martinho
paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
16359122
Reposted by Rui Gonçalo Martinho
David Vilchez @thevilchezlab.bsky.social · 03/09/2025
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...
nature.com
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
12915
Reposted by Rui Gonçalo Martinho
Frances Arnold @francesarnold.bsky.social · 03/09/2025
Private tour of the Louvre is a special treat. They were vacuuming the Sphinx. You may not have seen a Sphinx being brushed, so I am sharing.
31089
Reposted by Rui Gonçalo Martinho
Hadi Boukhatmi @muscleflylab.bsky.social · 30/08/2025
Our new preprint is out ! We uncover how adult Drosophila muscles respond to injury through a coordinated dialogue between hemocytes, tracheal cells, and muscles. Check it out and please share @igdrennes.bsky.social
01814
Reposted by Rui Gonçalo Martinho
bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/08/2025
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers www.biorxiv.org/content/10.1101/202…
0133
Reposted by Rui Gonçalo Martinho
Schubeler Lab @schubelerlab.bsky.social · 07/08/2025
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
211549
Rui Gonçalo Martinho @martinholab.bsky.social · 27/08/2025
Land of Port wine (Alto Douro Vinhateiro)
020
Reposted by Rui Gonçalo Martinho
Erna Magnúsdóttir @e-rna.bsky.social · 19/08/2025
Our department is advertising two academic positions. Come join us in beautiful Reykjavík. I can promise a very positive collegial atmosphere! #assistant_professor #physiology #cell_biology #physiology #neuroscience euraxess.ec.europa.eu/jobs/368529
euraxess.ec.europa.eu
Assistant professor in life sciences at the Faculty of Medicine
Two full time assistant professor positions are open for applications at the Department of Life Sciences, within the Faculty of Medicine at the University of Iceland.
0117
Rui Gonçalo Martinho @martinholab.bsky.social · 19/08/2025
"And it wouldn’t matter if CO2 were higher or lower than it is today, or whether the Earth was warmer or cooler as a result. It’s the rate of change in CO2 that gets you to Armageddon." www.theguardian.com/environment/...
theguardian.com
‘A climate of unparalleled malevolence’: are we on our way to the sixth major mass extinction?
The long read: Churning quantities of carbon dioxide into the atmosphere at the rate we are going could lead the planet to another Great Dying
000
Rui Gonçalo Martinho @martinholab.bsky.social · 19/08/2025
Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex www.mdpi.com/2221-3759/13...
mdpi.com
010
Rui Gonçalo Martinho @martinholab.bsky.social · 17/08/2025
www.nature.com/articles/s41...
nature.com
Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging
npj Aging - Psilocybin treatment extends cellular lifespan and improves survival of aged mice
100
Reposted by Rui Gonçalo Martinho
Laura Helmuth @laurahelmuth.bsky.social · 13/08/2025
Sex-reversal in birds (genetically male/female but appear female/male) is surprisingly common. Best detail: A genetically male bird called a laughing kookaburra had recently laid an egg. (1/2) By @phiejacobs.bsky.social on @science.org
science.org
‘Sex reversal’ is surprisingly common in birds, new study suggests
Survey of five Australian avians finds numerous discordant individuals, including a genetically male bird that had laid an egg
521980664
Rui Gonçalo Martinho @martinholab.bsky.social · 13/08/2025
bbc.com/reel/video/p...
bbc.com
Siberia's enormous hole in the ground is getting bigger
A large crater in Siberia's permafrost gives intriguing insights into the past.
010
Reposted by Rui Gonçalo Martinho
Itai Yanai @itaiyanai.bsky.social · 13/08/2025
Evolution is more like a tinkerer than an engineer. New things happen not by perfect engineering but by working with what's already available and repurposing existing objects through recombinations and modifications. This is a classic lesson for any kind of innovation, including that of new ideas..
25614
Reposted by Rui Gonçalo Martinho
Dr Sian Gramates @drglam.bsky.social · 11/08/2025
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
63376223
Rui Gonçalo Martinho @martinholab.bsky.social · 09/08/2025
Interested in pursuing a PhD to study the epigenetic functions of the meiotic synaptonemal complex? This research position offers an excellent entry point! The application deadline is 15 September. euraxess.ec.europa.eu/jobs/365827
euraxess.ec.europa.eu
1 (one) Research Grant in the scope of R&D project EPic-Oocyte, COMPETE2030-FEDER-00849800
Reference: Edital 10/2025/BI/iBiMED/EPic-Oocyte   NOTICE FOR THE AWARD OF GRANTS IN THE SCOPE OF R&D PROJECTS AND INSTITUTIONS
015
Rui Gonçalo Martinho @martinholab.bsky.social · 09/08/2025
www.bbc.com/news/article...
bbc.com
Jim Lovell: Astronaut who guided Apollo 13 safely back to Earth dies aged 97
The commander of Apollo 13 famously rescued his men from near certain death in space.
031
Rui Gonçalo Martinho @martinholab.bsky.social · 08/08/2025
000
Reposted by Rui Gonçalo Martinho
Harmit Singh Malik @harmitmalik.bsky.social · 06/08/2025
To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.
14470162
Reposted by Rui Gonçalo Martinho
Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 07/08/2025
A remarkable paper. Davisson and colleagues describe an in vitro reaction running under plausible prebiotic conditions that efficiently and stereoselectively aminoacylates a model tRNA. This suggests a path through which nature may have chosen L vs. D amino acids! www.biorxiv.org/content/10.1...
37126
Rui Gonçalo Martinho @martinholab.bsky.social · 31/07/2025
“Sleep, like ageing, may be an inescapable consequence of aerobic metabolism.” www.nature.com/articles/s41...
nature.com
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
000
Reposted by Rui Gonçalo Martinho
Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/07/2025
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
Diagram illustrating the two-hit model of retinoblastoma
49936
Reposted by Rui Gonçalo Martinho
Amoyel lab @amoyellab.bsky.social · 25/07/2025
🆕🧪‼️ New lab preprint! We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile. www.biorxiv.org/content/10.1...
biorxiv.org
Somatic cells compartmentalise their metabolism to sustain germ cell survival
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...
12612
Reposted by Rui Gonçalo Martinho
Emily Kolenbrander Ho @emkolen.bsky.social · 22/07/2025
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
59120
Reposted by Rui Gonçalo Martinho
Nature @nature.com · 16/07/2025
A huge project has analysed more than 1,000 claims about the immunity of Drosophila fruit flies in scientific papers published over some 50 years go.nature.com/4lxhwJB
go.nature.com
Giant study finds a research field that’s mostly reproducible
Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.
25316
Reposted by Rui Gonçalo Martinho
Dr Lindsey Fitzharris @drlindseyfitz.bsky.social · 06/07/2025
The Angel of Death (a winged skeletal creature) drops some deadly substances into a river near a town, symbolizing typhoid. Watercolor, 1912, by Richard Tennant Cooper. Typhoid was prevalent in the 19th and early 20th centuries, before people had regular access to clean water.
A painting showing a winged skeleton in dark and moody grays. From the Wellcome Collection, London.
433384