The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

In this study, Miserocchi et al. find that Tgf-β receptor signaling is a conserved, cell-intrinsic regulator of microglial differentiation in zebrafish. Disrupting this pathway blocks acquisition and ...

Heart regeneration requires coordinated immune activation, timely inflammatory resolution, and dynamic extracellular matrix (ECM) remodeling in addition to cardiomyocyte (CM) proliferation. However, t...

Summary: Interferon-Φ1 signaling is required for early neutrophil recruitment after zebrafish heart injury, revealing a key immune trigger that shapes inflammation and may influence efficient cardiac ...

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

The Pentagon has told lawmakers it needs roughly $80 billion, mostly to cover the cost of the war in Iran.

A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.

In the rapidly evolving field of biomedical research, the role of animal models has long been a topic of scientific and ethical debate. However, despite advancements in alternative modeling approaches...

McCune et al. demonstrate that progranulin enforces myeloid fate by regulating JAK2/STAT3 and uncover functional differences between two embryonically derived macrophage populations. These findings pr...

This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...

Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...