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Lynch Syndrome Ireland

@lsireland.bsky.social
232 followers 307 following 278 posts

Central point for Lynch syndrome related issues in Ireland. An inherited predisposition to certain types of cancer e.g. colon and endometrial.

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Reposted by Lynch Syndrome Ireland
International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 19/08/2026
🧬 Lynch syndrome–associated colorectal cancers do not rely on a single Wnt pathway mutation. New research reveals a diverse spectrum of genetic alterations driving Wnt activation in MLH1-associated tumors: Read full paper: pubmed.ncbi.nlm.nih.gov/41556860/ #LynchSyndrome #ColorectalCancer
pubmed.ncbi.nlm.nih.gov
MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations - PubMed
MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
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Reposted by Lynch Syndrome Ireland
Hutlab @hutlab.bsky.social · 25/08/2026
Congratulations to Nanako, @longnguyen.bsky.social and the whole team for their new paper out today 🎉🥳 - Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution Link - gut.bmj.com/content/earl...
gut.bmj.com
Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution
Recent work in Gut has highlighted multi-kingdom interactions between gut bacteria and bacteriophage (‘phage’) as contributors to Crohn’s disease.1 Whether similar alterations characterise colorectal ...
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Reposted by Lynch Syndrome Ireland
UT MD Anderson Cancer Center @mdanderson.bsky.social · 26/08/2026
Mismatch repair testing can tell oncologists important information about patients newly diagnosed with colorectal cancer. How these tests combined with clinical trials aim to expand the benefit of immunotherapy to more patients. #OncSky #EndCancer
spr.ly
DNA mismatch repair status: What colorectal cancer patients should know
What does MMR deficiency mean for colorectal cancer patients? S. Daniel Haldar, M.D., explains testing, the link to Lynch syndrome and how MMR status helps determine who will benefit from immunotherapy.
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Reposted by Lynch Syndrome Ireland
Scarlett Lillian Shiloh @scarsresearch.bsky.social · 07/09/2026
I had the great honor of being on the @cgaigc.com podcast to talk about my experiences being a neurodivergent person living with Lynch syndrome~ ✨ I talked a bit about what neuro-inclusive care means to me. You can listen to the whole podcast here: www.cgaigc.com/podcast/epis...
cgaigc.com
Podcasts | CGA-IGC
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Reposted by Lynch Syndrome Ireland
International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 27/11/2025
November is Pancreatic Cancer Awareness Month 💜 It’s the deadliest of the common cancers due to late detection. Researchers stress genetic testing - hereditary risk matters. Know your family history. Advocate for early detection. 💜 Read more 👉 shorturl.at/eKuTB #PancreaticCancer #GeneticTesting
shorturl.at
Genetic testing and pancreatic cancer: Why is it important?
By Eric Traub | Northside Hospital Cancer Institute Pancreatic cancer: arguably the most haunting pair of words in the medical world. Numerous high-profile people have succumbed to pancreatic cancer a...
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Reposted by Lynch Syndrome Ireland
International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 25/11/2025
We’re proud to present the current Council members of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), driving progress in research, collaboration, and patient care worldwide. Learn more about us👉 shorturl.at/6cyJV #Genetics #GIHealth #HereditaryGICancer #InSiGHT
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 12/11/2025
We had the 3rd meeting of the UK EOCRC Research Consortium in beautiful Edinburgh yesterday supported by British Society of Gastroenterology (BSG) and @bowelcanceruk.bsky.social attended by over 50 UK academics - celebrating our first project funding success only 1 year after foundation
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 27/11/2025
Diagnostic yield of colonoscopy in Lynch Syndrome We demonstrate a high adenoma burden with distinct phenotypic and gene-specific characteristics in a UK LS population undergoing high quality surveillance fg.bmj.com/content/earl...
fg.bmj.com
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Reposted by Lynch Syndrome Ireland
CBS Philadelphia @cbsphiladelphia.bsky.social · 08/11/2025
Chemo and surgery failed to treat one woman's advanced cancer. Hope emerged through genetic testing, revealing an unexpected cause. www.cbsnews.com/news/advanced-ovari… 
cbsnews.com
A woman's cancer seemed incurable. Identifying a rare genetic condition saved her life.
Chemo and surgery failed to treat Diane Davis' advanced cancer. Things seemed hopeless until genetic testing found an unlikely culprit.
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 16/11/2025
We are looking for our new Tom Smith Clinical Research Fellow in #LynchSyndrome and Early Onset ColorectalCancer with @trevorgraham.bsky.social in translational science … thanks to 40tude curing colon cancer for supporting this fellowship - get in touch! @stmarksgenomics.bsky.social @icr.ac.uk
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Reposted by Lynch Syndrome Ireland
CGA-IGC @cgaigc.com · 13/10/2025
📣Missed #CGAIGC25 this year? Catch the short discussion between Prof Sir John Burn & @swatipatelmd.bsky.social sharing long-awaited CaPP3 results, a follow-up to the landmark CaPP2 trial showing aspirin’s 💊role in lowering cancer risk in #LynchSyndrome 👉 tinyurl.com/msshdb5b #HereditaryGICancer
tinyurl.com
Baby Aspirin and Cancer Prevention in Lynch Syndrome: New CaPP3 Results
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
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Reposted by Lynch Syndrome Ireland
CGA-IGC @cgaigc.com · 22/10/2025
🧬 October = National Family History Month! Read the blog📜👉 tinyurl.com/bdhjjv83 Reminding us that even in the era of🧬testing, 👪history is still the foundation of hereditary cancer care. Asking the right❓& sharing results can save lives across generations. #HereditaryGICancer
tinyurl.com
National Family History Month: A Reminder for Providers and Genetic Counselors!
October’s National Family History Month is an important opportunity to emphasize how family history drives cancer risk assessment, genetic referrals, and prevention. Even with growing access to geneti...
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Reposted by Lynch Syndrome Ireland
CGA-IGC @cgaigc.com · 30/09/2025
Day 3 of Hereditary Cancer Awareness Month 🧬 also highlights Gynecologic Cancer Awareness Month 💜. Watch the video on ctDNA for Endometrial Cancer 🎥 tinyurl.com/3fajahme + listen to our podcast on Lynch syndrome & NCCN updates 🎧 tinyurl.com/2jmvmt7t #HereditaryGICancer #LynchSyndrome
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Reposted by Lynch Syndrome Ireland
rpm @parabello.bsky.social · 09/10/2025
I have been able to connect with other people with Lynch Syndrome, and this has helped me so much, as I felt so alone when I was first diagnosed in 2024.
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Reposted by Lynch Syndrome Ireland
Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 15/10/2025
While the underlying genetic defects differ significantly between Lynch syndrome and FAP, the pathogenetic mechanisms in these two disorders represent canonical pathways of young-onset colorectal cancer carcinogenesis. www.nature.c...
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Reposted by Lynch Syndrome Ireland
Matthew Wright @matthew-wright.bsky.social · 09/10/2025
Back to London early as today’s my date for ongoing Lynch Syndrome bowel/prostate cancer research project at Royal Marsden. I don’t have the genetic flaw so am part of the control group. Important stuff x
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Reposted by Lynch Syndrome Ireland
Alliance for Clinical Trials in Oncology @alliance-org.bsky.social · 18/10/2025
Frank Sinicrope MD of Mayo Clinic Comprehensive Cancer Center will present new subgroup findings from the #ATOMIC trial (Alliance A021502) in a poster session at #ESMO25. Data highlight outcomes in sporadic vs. Lynch syndrome–related dMMR colon cancer. Sunday, Oct 19. @ALLIANCE_org #NCI #NCTN #CRCsm
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 23/10/2025
Low Yield of Genetic Testing in Serrated Polyposis Syndrome journals.lww.com/ctg/fulltext...
journals.lww.com
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Lynch Syndrome Ireland @lsireland.bsky.social · 11/10/2025
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JCO Oncology Practice ascopubs.org/doi/10.1200/...
ascopubs.org
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JCO Oncology Practice
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Reposted by Lynch Syndrome Ireland
Randi Weingarten 🖇️📚✊🇺🇸 @rweingarten.bsky.social · 10/10/2025
New study shows COVID vaccines: 💉Reduced people’s risk of ER by 29% 💉Reduced risk of hospitalizations by 39% 💉Reduced the risk of death by 64% 💉Vaccination was effective in all age groups and “in persons with or without major chronic conditions.” www.scientificamerican.com/article/new-...
scientificamerican.com
Annual COVID Vaccines Save Lives, New Study Shows
A new study shows that receiving an updated COVID vaccine reduced people’s risk of severe disease and death in all age groups, regardless of immunity from prior infection or vaccination
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Reposted by Lynch Syndrome Ireland
Prof Sheena Cruickshank @sheencr.bsky.social · 10/10/2025
Excellent op Ed about the issues with single vaccines published in response to Trumps Statement about single shots for Measles, mumps and rubella as well as CDC call for single vaccine manufacturer 🧵🧪#HealthPolicy
cidrap.umn.edu
CIDRAP Op-Ed: Why the CDC director is wrong about the MMR vaccine
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Reposted by Lynch Syndrome Ireland
EACR - European Association for Cancer Research @helloeacr.bsky.social · 10/10/2025
Join our free, open access webinar with the Young European Hematology Association & @yefis-immunology.bsky.social, featuring 3 presentations on CAR T-cells! 📅 19 November 14:00-15:30 CET 🌍 Zoom us02web.zoom.us/webinar/regi...
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Reposted by Lynch Syndrome Ireland
International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 19/09/2025
🚨 It’s here! The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live! 🔗 Check out the full program: insight2026.org/scientific-programme 🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines #InSiGHT2026 #HereditaryCancer #GICancerResearch
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Reposted by Lynch Syndrome Ireland
ralucagordan.bsky.social @ralucagordan.bsky.social · 03/10/2025
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
cell.com
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.
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Reposted by Lynch Syndrome Ireland
National Screening Service @nsshse.bsky.social · 07/10/2025
Mary Kennedy's powerful story about bowel screening inspired thousands of others to take action. Her message is simple: even if you feel well, screening can save your life. Read how her story made an impact: tinyurl.com/PPP-story-ca... #ChooseScreening #BowelScreen
tinyurl.com
Shouting from the rooftops: how a powerful patient story about bowel screening inspired others to take action
A social media campaign highlighting the power of co-designing with our screening participants to share human stories.
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Reposted by Lynch Syndrome Ireland
Cancer Trials Ireland @cancertrialsie.bsky.social · 30/09/2025
Today, we launch #CancerNeedsTrials. Cancer trials give patients access to tomorrow’s treatments today — but in Ireland, access is too limited. We’re calling on the government to invest so more patients can benefit. Add your voice: bit.ly/4nos5iL #CancerNeedsTrials
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Lynch Syndrome Ireland @lsireland.bsky.social · 28/09/2025
lynchsyndromeireland.com/2025/09/28/b...
lynchsyndromeireland.com
Blame-Ridden Language in Medicine
Problematic Language: Words like claims, denies, and failed treatment subtly blame or cast doubt on patients. Dehumanizing Terms: Using labels like diabetic or ep…
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 27/09/2025
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
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Reposted by Lynch Syndrome Ireland
Kevin Monahan @kevinmonahan.bsky.social · 27/09/2025
Genetic testing appears to have limited utility in SPS patients and may primarily identify those with an incidental diagnosis of Lynch syndrome pubmed.ncbi.nlm.nih.gov/41002021/
pubmed.ncbi.nlm.nih.gov
Low Yield of Genetic Testing in Serrated Polyposis Syndrome - PubMed
Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing appears to have...
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Reposted by Lynch Syndrome Ireland
Nature Reviews Cancer @natrevcancer.nature.com · 25/09/2025
nature.com
Unlocking the potential of urine-based liquid biopsy through improved reporting and standardization
Nature Reviews Cancer, Published online: 25 September 2025; doi:10.1038/s41568-025-00882-zUrine-based tumour DNA detection enables non-invasive profiling of urological malignancies and may inform on distant cancers via trans-renal cell-free DNA (cfDNA). Here the authors propose the ‘minimal urine methods in experiments’ (MUMIE) framework to enhance validation and standardization of urinary cfDNA biomarkers.
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Reposted by Lynch Syndrome Ireland
Prof Sheena Cruickshank @sheencr.bsky.social · 23/09/2025
So the politicisation of health continues in the States and I want to highlight a few key things 🧪🧵
theguardian.com
Trump attacks Tylenol as officials unveil highly contentious conclusions on autism
President says acetaminophen – also known as paracetamol - increases risk when taken by pregnant women, assertion contradicted by research
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Reposted by Lynch Syndrome Ireland
Sarah Fitzgibbon @sarahfitzwimin.bsky.social · 17/06/2025
Doing Cancer Wrong: I have an innate tendency to do precisely the opposite of what society expects from me. adventuresofasickdoctor.blogspot.com/2025/06/doin...
adventuresofasickdoctor.blogspot.com
Doing Cancer Wrong
doctor cancer blog
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Reposted by Lynch Syndrome Ireland
Tracy Bale @thebalelab.bsky.social · 18/09/2025
Fantastic piece in Nature Reviews Neuro by @nicolecrust.bsky.social on the importance of science communication. My take? Everything matters - just do something. It will make a difference for how science is valued and trusted, how community understands. Let's get out there and communicate! 👏
rdcu.be
The unexpected value of communicating science to the public
Nature Reviews Neuroscience - As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much...
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Reposted by Lynch Syndrome Ireland
JAMA @jama.com · 18/09/2025
Endometriosis is a chronic inflammatory disease in which cells similar to those lining the uterus are present outside of the uterus. This JAMA Patient Page describes endometriosis development, as well as its signs and symptoms, diagnosis, and treatment. ja.ma/3K53fpL
Informational diagram explaining endometriosis: its causes, symptoms, and treatments. Text includes definitions and risk factors. Anatomic drawings show affected areas like the uterus, fallopian tubes, and ovaries.
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Lynch Syndrome Ireland @lsireland.bsky.social · 18/09/2025
lynchsyndromeireland.com/2025/09/18/s...
lynchsyndromeireland.com
Sometimes we need permission to be grumpy
Sometimes we need permission to be grumpy and ungrateful and selfish. We need to allow ourselves the opportunity to take a day off from being a better person.  Then we can wake up again the next da…
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Lynch Syndrome Ireland @lsireland.bsky.social · 18/09/2025
lynchsyndromeireland.com/2025/09/18/t...
lynchsyndromeireland.com
THISISGO.IE
The platform (on-line portal) which was developed ‘by patients for patients’ in partnerships with healthcare professionals, was launched in Sept 2021 and is aiming to change the landscape in how we…
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Lynch Syndrome Ireland @lsireland.bsky.social · 18/09/2025
lynchsyndromeireland.com/home-2/blog/
lynchsyndromeireland.com
Lynch Syndrome Ireland
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Reposted by Lynch Syndrome Ireland
Fergal Bowers @fergalbowers.bsky.social · 18/09/2025
www.rte.ie/news/ireland...
rte.ie
15,000 more beds needed by 2040 - Nursing Homes Ireland
Ireland's ageing population means there will be a sharp rise in demand for both home support hours and long-term residential care beds up to 2040.
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Lynch Syndrome Ireland @lsireland.bsky.social · 17/09/2025
lynchsyndromeireland.com/2025/09/17/m...
lynchsyndromeireland.com
Medical misogyny and “harrowing” experiences: what are doctors doing to improve outpatient gynaecological procedures?
This is a subject recently explored by a UK parliamentary inquiry. Reporting its findings in December 2024, the Women and Equalities Committee found that doctors were too often dismissive of sympto…
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Lynch Syndrome Ireland @lsireland.bsky.social · 16/09/2025
lynchsyndromeireland.com/2025/09/16/w...
lynchsyndromeireland.com
What to expect from the NHS Bowel Screening Programme for people with Lynch syndrome
If you live with Lynch syndrome, regular bowel screening is one of the most effective ways to reduce your risk of bowel (colorectal) cancer and catch problems early. The NHS Bowel Cancer Screening …
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Reposted by Lynch Syndrome Ireland
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 15/09/2025
ICYMI: New online! Vaccine for pancreatic and colorectal cancer: phase I AMPLIFY-201 trial
nature.com
Vaccine for pancreatic and colorectal cancer: phase I AMPLIFY-201 trial
Nature Reviews Gastroenterology & Hepatology, Published online: 08 September 2025; doi:10.1038/s41575-025-01123-2Vaccine for pancreatic and colorectal cancer: phase I AMPLIFY-201 trial
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Reposted by Lynch Syndrome Ireland
Cystic Fibrosis Ireland @cfireland.bsky.social · 15/09/2025
The 2025 Fuel Allowance lump sums are scheduled for the last week of September 2025 and the first week of January 2026. The 2025/2026 Fuel Allowance season begins on Monday, September 22, 2025, and the allowance is paid for 28 weeks.
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Reposted by Lynch Syndrome Ireland
Digestive Cancers Europe @digestivecancerseu.bsky.social · 15/09/2025
How do #patents affect #AccessToMedicines? On 🗓️6 November, 16:00–17:30 CET, we invite patient advocates to a dedicated 🖥️webinar on the role of patents in shaping the availability of medicines. Register here➡️ events.zoom.us/ev/ApxG1qgYa... #MakingAccessHappen #DiCE @mepsagainstcancer.bsky.social
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Lynch Syndrome Ireland @lsireland.bsky.social · 14/09/2025
lynchsyndromeireland.com/2025/09/14/m...
lynchsyndromeireland.com
Making Listening a Core Competency in Healthcare
In practice, listening remains underdeveloped. Systems reward efficiency, clinicians are pressed for time, and communication is often reduced to extracting the minimum information needed to move fo…
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Lynch Syndrome Ireland @lsireland.bsky.social · 14/09/2025
lynchsyndromeireland.com/2025/09/14/g...
lynchsyndromeireland.com
Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome
Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting and removing adenomas. The existence of gene-specific differences in adenoma detection has be…
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Lynch Syndrome Ireland @lsireland.bsky.social · 13/09/2025
lynchsyndromeireland.com/2025/09/13/w...
lynchsyndromeireland.com
World GO Day Planned Activities in Ireland
Visit the post for more.
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Lynch Syndrome Ireland @lsireland.bsky.social · 13/09/2025
lynchsyndromeireland.com/2025/09/13/t...
lynchsyndromeireland.com
Talking to your children about Cancer
Visit the post for more.
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Lynch Syndrome Ireland @lsireland.bsky.social · 13/09/2025
If you or a loved one have been diagnosed with #bowelcancer or you're a member of the public who wants to understand more about the disease- risk-factors, diagnosis, treatments, research, advocacy check out this great booklet from @RCSI_Irl 👇 Free to download
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Lynch Syndrome Ireland @lsireland.bsky.social · 12/09/2025
x.com/Lynchsyndrom...
x.com
lynch syndrome irl @lsireland.bsky.social on X: "Well done Kevin. Well deserved." / X
Well done Kevin. Well deserved.
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Lynch Syndrome Ireland @lsireland.bsky.social · 11/09/2025
lynchsyndromeireland.com/2025/09/11/o...
lynchsyndromeireland.com
Occurrence of dMMR/MSI-H tumor during follow-up in Lynch syndrome patients treated with immune checkpoint inhibitors for metastatic digestive cancer
2015 and 2024: a retrospective analysis of a monocentric prospective cohort study Highlights Patients with LS treated with ICIs are at risk of metachronous dMMR/MSI-H cancers (8% of cohort). The mo…
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