Sign in

Matt Hoare

@matthoare20.bsky.social
169 followers 236 following 10 posts

Assistant Professor of Hepatology at the University of Cambridge. Honorary Consultant in Hepatology at Cambridge University Hospitals.

PostsRepliesMedia
Matt Hoare @matthoare20.bsky.social · 22/12/2025
Christmas holidays in Cambridge
010
Reposted by Matt Hoare
Prof Sam Illingworth @samillingworth.com · 01/08/2025
🩺 Liver cancer cases could double by 2050 A new @thelancet.com Commission warns of 1.5M annual liver cancer cases by 2050 but says 60% are preventable through better HBV vaccination & alcohol reduction. Prevention is possible. Action is urgent. 🔗 www.thelancet.com/journals/lan... #SciComm 🧪
thelancet.com
Reversing the rise of liver cancer
Imagine a future where the global incident cases of liver cancer almost doubles, rising from 870 000 cases in 2022 to over 1·5 million in 2050. This scenario, and all the attendant harms to health and...
511245
Matt Hoare @matthoare20.bsky.social · 29/07/2025
www.theguardian.com/society/2025... Policy changes and enhanced early detection key to reducing death from HCC.
theguardian.com
Lifestyle changes and vaccination ‘could prevent most liver cancer cases’
Lancet Commission says three in five cases preventable with action on obesity, alcohol and hepatitis
230
Reposted by Matt Hoare
Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · 25/07/2025
Registrations for the Early Cancer Institute Annual Symposium 2025, focusing on the latest developments in early cancer research, are open! 📅 Thurs 9 October 2-6pm 📍 CRUK Cambridge Institute, CB2 0RE Find out more and register ➡️ zurl.co/bH4wU @cambridgebrc.bsky.social @cambridge-scm.bsky.social
033
Matt Hoare @matthoare20.bsky.social · 27/03/2025
Great to be at the Bridgewater Hall in Manchester for the annual HCC-UK conference. Exciting day of great speakers.
030
Reposted by Matt Hoare
Natalia Brzozowska @nataliabrzozowska.bsky.social · 12/03/2025
Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12] www.nature.com/articles/s41...
nature.com
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
3175
Matt Hoare @matthoare20.bsky.social · 10/03/2025
Delighted to announce our new paper by Natalia Brzozowska published today, demonstrating somatic escape mutants from a deleterious germline disease. rdcu.be/ecSNo
rdcu.be
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
Nature Genetics - The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These...
160
Reposted by Matt Hoare
Stefan Marciniak @profmarciniak.bsky.social · 10/03/2025
Delighted to have this work published today. A superb collaboration with @matthoare20.bsky.social and @joechambers.bsky.social www.nature.com/articles/s41...
nature.com
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
0198
Reposted by Matt Hoare
Sarah Aitken @s-j-aitken.bsky.social · 27/02/2025
1/n 👩‍💻Research Assistant in Computational Biology 🧬analyse somatic mutations in #HCC 👨‍⚕️international collaboration with Dr Matt Hoare @matthoare20.bsky.social 🌍based at the Early Cancer Institute, University of Cambridge (UK) 🗓️apply by 31 March 2025 www.jobs.cam.ac.uk/job/50461/
jobs.cam.ac.uk
Research Assistant (Computational biology) (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant (Computational biology) (Fixed Term) in the Department of Oncology at the University of Cambridge.
152
Matt Hoare @matthoare20.bsky.social · 25/02/2025
🚨🚨Job Alert🚨🚨 Do you have skills in computational biology? Do you want to work on somatic mutations in #hcc?? Do you want to work in an international collaboration with @s-j-aitken.bsky.social? Come and join us in Cambridge! 🗓️ Closing date 31/Mar/2025 www.jobs.cam.ac.uk/job/50461/
jobs.cam.ac.uk
Research Assistant (Computational biology) (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant (Computational biology) (Fixed Term) in the Department of Oncology at the University of Cambridge.
033
Matt Hoare @matthoare20.bsky.social · 19/02/2025
Many congratulations to Tom Bird and team from @cruk-si.bsky.social for the new paper on correlation between and human #HCC and murine models with specified oncogenic drivers. A landmark paper years in the making: rdcu.be/eaxE2
rdcu.be
Human-correlated genetic models identify precision therapy for liver cancer
Nature - As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which...
020
Reposted by Matt Hoare
Medicine at Cambridge @medcambridge.bsky.social · 24/01/2025
📢 Job opportunities! We're hiring a postdoctoral Research Associate (Fixed Term) in structural biology to join Professor Arthur Kaser's lab at #CITIID and study purine metabolism, autoimmunity, and inflammation. Apply by 2 February: buff.ly/4jmVgkR @uniofcam.bsky.social
buff.ly
Post-doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Post-doctoral Research Associate (Fixed Term) in the Department of Medicine at the University of Cambridge.
011
Reposted by Matt Hoare
The Francis Crick Institute @crick.ac.uk · 23/01/2025
Join our next #MedicineAtTheCrick event on Thursday 13 March, where researchers and clinicians will explore tissue somatic evolution in ageing and disease. The event will be hosted by @ciccarellilab.bsky.social and Ilaria Malanchi www.eventbrite.co.uk/e/medicine-a...
eventbrite.co.uk
Medicine at the Crick
The good, the bad, and the ugly: tissue somatic evolution in ageing and disease
195
Reposted by Matt Hoare
Melina Manolas, MD, MPH @melinamanolas.bsky.social · 23/01/2025
Estimated burden of #MASLD and #MASH over the next 30 years.😮 Future is grim if we don't take active approach from all disciplines and angles, including policy change. jamanetwork.com/journals/jam...
jamanetwork.com
Burden of Metabolic Dysfunction–Associated Steatotic Liver Disease, 2020 to 2050
This decision analytical modeling study estimates the burden of metabolic dysfunction–associated steatotic liver disease among US adults from 2020 to 2050.
053
Matt Hoare @matthoare20.bsky.social · 07/01/2025
Totally rocks, when you get a student onto a PhD fellowship!
media.tenor.com
someone is holding a fortune cookie that says " i love it when a plan comes together "
ALT: someone is holding a fortune cookie that says " i love it when a plan comes together "
030
Reposted by Matt Hoare
Adrian Liston @labliston.bsky.social · 13/12/2024
A very rare position for an immunology professorship at Cambridge. Something to think about! www.jobs.cam.ac.uk/job/49381/
jobs.cam.ac.uk
Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge
Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.
35248
Matt Hoare @matthoare20.bsky.social · 11/12/2024
All medics and scientists interested in #HCC, the HCC-UK annual conference will be in Manchester on 27th-28th March 2025. Register now at: hcc-uk.org.uk
hcc-uk.org.uk
HCC-UK
030
Reposted by Matt Hoare
NEJM.org @nejm.org · 06/12/2024
Hello, #MedSky community! We’re excited to begin our Bluesky journey. Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
32860187