Reposted by Edward WallaceThe Endless Narf of the Waves @narfnra.bsky.social · 20/09/2026it made me really happy when i learned that the way mutation ultimately creates new proteins is that it just randomly activates or inactivates parts of dna that start coding and your cellular machinery is like guess we makin 🟡 now. does 🟡 do anything. idk. guess we'll find out if we die 183
Reposted by Edward WallaceEdward Wallace @ewjwallace.bsky.social · 19/08/2026Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!ewallace.github.ioPostdoctoral position in fungal engineering biology 11117
Edward Wallace @ewjwallace.bsky.social · 19/08/2026Yeast colleagues: any idea what @zymoresearch.bsky.social do in their frozen yeast transformation kit for or instead of carrier DNA? zymoresearch.eu/products/fro... Kit looks great and is highly cited, I'm wondering about publicly available info ideally that I can cite in a review paper.zymoresearch.euFrozen-EZ Yeast Transformation II KitQuickly and simply make competent yeast cells for highly efficient transformations. 100
Edward Wallace @ewjwallace.bsky.social · 19/08/2026Bunsen burners limitations in aseptic technique! Data-driven evidence here in a neat and careful study For what it's worth, the senior author Hannah Gavin is a lovely human who I used to occasionally play music with in Chicago. 020
Edward Wallace @ewjwallace.bsky.social · 19/08/2026Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!ewallace.github.ioPostdoctoral position in fungal engineering biology 11117
Reposted by Edward WallaceEdward Wallace @ewjwallace.bsky.social · 14/07/2026Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...scholar.google.com 146
Edward Wallace @ewjwallace.bsky.social · 14/07/2026Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...scholar.google.com 146
Reposted by Edward WallaceAlex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour... 01619
Reposted by Edward WallaceShiv Grewal @grewalsh.bsky.social · 08/07/2026Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41... 17333
Reposted by Edward WallaceMara Duncan @mcduncanlab.bsky.social · 23/06/2026Yes, I've done this. It's always a delight to work with SGD. 031
Edward Wallace @ewjwallace.bsky.social · 24/06/2026Where are we at on acceptable abbreviations for fluorescent proteins? Like, GFP for green fluorescent protein sure, but is mNG for mNeonGreen too much? Etc? Your strongest opinions and arguments invited. 400
Edward Wallace @ewjwallace.bsky.social · 12/06/2026What's the state of genomes that report on early animal / holozoan evolution? A student project in my lab on evolution of RNA-binding proteins is testing the hypothesis of a gene duplication in early metazoa, we want to look for homologs in in holozoa beyond Monosiga. @jlsteenwyk.bsky.social ? 100
Reposted by Edward WallaceSophie Mason @sophiemason.bsky.social · 30/05/2026I worked for UKRI for seven years and in my experience, the short timescales were 100% because of delays in central government. Usually because of delays in sign off by a minister; in the worst cases, due to number 10 comms teams insisting we hold back so the PM could announce it or whatever. 1/3 77335
Reposted by Edward WallaceIGMM-Montpellier @igmm-montpel.bsky.social · 05/05/2026Save the date : Seminar by Edward Wallace from the University of Edinburgh on Tuesday 12th May at 11h @ewjwallace.bsky.social @edinburgh-uni.bsky.social 053
Edward Wallace @ewjwallace.bsky.social · 29/04/2026How do fungi grow directionally? We think part of the mechanism involves local translation of mRNA near the tip, especially of cell wall components. Delighted to share our preprint showing that an RNA-binding protein, SsdA/Ssd1, is trafficked to the tip of growing fungal filaments. 1134
Edward Wallace @ewjwallace.bsky.social · 23/02/2026I am learning a lot from this debate about the last eukaryotic common ancestor. It's thought-provoking to have competing hypotheses and perspectives argued out there in the open. Here, the two arguments are internally consistent, yet different conclusions... so where's the wrong assumption? 021
Edward Wallace @ewjwallace.bsky.social · 23/02/2026Today's @gautamdey.bsky.social seminar on Evolutionary Cell Biology is mind-blowing in so many ways. Dinoflagellates don't have histones!?!?! And BEAUTIFUL microscopy. 050
Reposted by Edward WallaceThe Daum Lab @daumlab.bsky.social · 15/01/2026We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr... 0103
Reposted by Edward WallaceEvelina Tutucci @anilevetu.bsky.social · 10/01/2026Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings! 32511
Reposted by Edward WallaceBungo Akiyoshi @bungoakiyoshi.bsky.social · 11/11/2025Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...findaphd.comDissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh on FindAPhD.comPhD Project - Dissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh, listed on FindAPhD.com 01811
Reposted by Edward WallaceAlexis Rohou @alexisrohou.bsky.social · 31/10/2025Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry. 3162
Reposted by Edward WallaceThe Daum Lab @daumlab.bsky.social · 29/10/2025We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66.... 0199
Edward Wallace @ewjwallace.bsky.social · 10/10/2025We had a great fungal minisymposium yesterday @edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together. Next one January or February TBA: Email me to be added to the email list! 020
Reposted by Edward WallaceMarie Winz @mariewinz.bsky.social · 09/09/2025Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel. 1108
Reposted by Edward WallaceJavier Santoyo @jsantoyo.bsky.social · 04/09/2025Translon: a single term for translated regions. #Translation @natmethods.nature.com 074
Reposted by Edward WallaceSaccharomyces Genome Database @yeastgenome.bsky.social · 20/08/2025Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited 084
Reposted by Edward WallaceDelma Childers @childerslab.bsky.social · 01/08/2025New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh. www.biorxiv.org/content/10.1...biorxiv.orgAntifungal exposure can enhance Candida glabrata pathogenesisAzole antifungal drugs directly inhibit lanosterol 14-α-demethylase and indirectly affect the expression of metabolic, transmembrane transporter, and cell wall organization genes in fungal pathogens. ... 153
Reposted by Edward WallaceRichard Sever @richardsever.bsky.social · 31/07/2025bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏 104934
Edward Wallace @ewjwallace.bsky.social · 31/07/2025V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation. 140
Reposted by Edward Wallacec0nc0rdance @c0nc0rdance.bsky.social · 31/07/2025I NEED to tell you the story of Tae Heung “William” Kim. He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease. He's a *legal permanent resident* of the United States. And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas. 131120658
Edward Wallace @ewjwallace.bsky.social · 30/07/2025Absolutely loving the random ribosome dreams that appear on the #RNAbiology feed. 110
Edward Wallace @ewjwallace.bsky.social · 24/07/2025Wellcome to bluesky @edinburghbiology.bsky.social - Edinburgh School of Biological Sciences! This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw... 010
Reposted by Edward WallaceRobert Arkowitz @robertarkowitz.bsky.social · 23/07/2025wellcome.org/news/can-bio...wellcome.orgCan bioimaging build capacity in fungi research? | News | WellcomeDr Elizabeth Ballou from the University of Exeter writes about her research on antifungal resistance and how bioimaging could help build capacity in fungal research. 074
Reposted by Edward WallaceMichael Baym @baym.lol · 22/07/2025It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_ This results in a near-logarithmic overcounting of large molecules! 5307
Edward Wallace @ewjwallace.bsky.social · 17/07/2025THERE ARE TRANSMEMBRANE RNAs NOW?!?!?!? rnajournal.cshlp.org/content/31/8...rnajournal.cshlp.orgImplications for OLE RNA as a natural integral membrane RNA A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms 150
Reposted by Edward WallaceWolfgang Huber @wkhuber.bsky.social · 04/07/2025If you work as an academic and behave like your job can be done by a machine, then you should not have that job. 1213
Reposted by Edward WallaceHannah Ledvina Ph.D. @hannahledvina.bsky.social · 02/07/2025Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.rdcu.beFunctional amyloid proteins confer defence against predatory bacteriaNature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a... 616653
Reposted by Edward WallaceBiochemical Society @biochemsoc.bsky.social · 02/07/2025#TLUK25 finishing strong! This morning we heard from those with emerging topics within the Translation field. We would like to thank all attendees for their amazing engagement - we will see you next year. 083
Reposted by Edward WallaceHee-Kyung Ahn @hee-kyung-ahn.bsky.social · 30/06/2025@instmolplantsci.bsky.social very own Amy Newell presents her work on shade response in plants and translational regulation at the #TLUK25!! @biochemsoc.bsky.social 0114
Edward Wallace @ewjwallace.bsky.social · 02/07/2025Recovering from a wonderful 3 days of translation, ribosomes, post-transcriptional regulation at #TLUK25 the Translation UK conference! 060
Edward Wallace @ewjwallace.bsky.social · 27/06/2025Evidence for Safety of Neurospora Species... Feeling this energy today after a sequence I wanted to synthesize raised a pointless biosecurity flag. pmc.ncbi.nlm.nih.gov/articles/PMC...pmc.ncbi.nlm.nih.govEvidence for Safety of Neurospora Species for Academic and Commercial Uses 010
Edward Wallace @ewjwallace.bsky.social · 18/06/2025School of Biological Sciences symposium: what a wonderful event. So many good talks, great ideas, great conversations, brings our diverse research community together. 120
Reposted by Edward WallaceCentro de Investigaciones Biológicas Margarita Salas (CSIC) @cib-csic.bsky.social · 12/06/2025#REMINDER #CIBseminars Translation on Demand: Exploring the Role of Ribosome Diversity in Plant Adaptation Catharina Merchante, ISHM La Mayora (Universidad de Málaga) 📅June 12 ⏰12pm 022
Reposted by Edward Wallaceharvestwoman.bsky.social @harvestwoman.bsky.social · 10/06/2025Meantime, if your grant proposal has any mention of mRNA, better change it to Transcript that the Ribosome Uses to Make Proteins (TRUMP) because otherwise it's not getting approved. 04112
Edward Wallace @ewjwallace.bsky.social · 11/06/2025Where do you draw the boundaries between bioinformatics and Exploratory Data Analysis? In discussion with colleagues, wondering about tools like PyMOL and genome browsers - these are clearly used for exploratory data analysis, but aren't exactly Exploratory Data Analysis a la Tukey / data science. 010
Reposted by Edward WallaceBungo Akiyoshi @bungoakiyoshi.bsky.social · 10/06/2025Published now. doi.org/10.1242/jcs....doi.orgHypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosisSummary: This Hypothesis article proposes that key aspects of meiosis evolved prior to mitosis in ancestral eukaryotes. 1158