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Edward Wallace

@ewjwallace.bsky.social
2.2K followers 663 following 140 posts

Group leader, RNA and cellular adaptation in fungi. Carpentries data science instructor. Trying to make my corner of science a better place. Opinions my own. ewallace.github.io

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Reposted by Edward Wallace
The Endless Narf of the Waves @narfnra.bsky.social · 20/09/2026
it made me really happy when i learned that the way mutation ultimately creates new proteins is that it just randomly activates or inactivates parts of dna that start coding and your cellular machinery is like guess we makin 🟡 now. does 🟡 do anything. idk. guess we'll find out if we die
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Reposted by Edward Wallace
Edward Wallace @ewjwallace.bsky.social · 19/08/2026
Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!
ewallace.github.io
Postdoctoral position in fungal engineering biology
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Edward Wallace @ewjwallace.bsky.social · 19/08/2026
Yeast colleagues: any idea what @zymoresearch.bsky.social do in their frozen yeast transformation kit for or instead of carrier DNA? zymoresearch.eu/products/fro... Kit looks great and is highly cited, I'm wondering about publicly available info ideally that I can cite in a review paper.
zymoresearch.eu
Frozen-EZ Yeast Transformation II Kit
Quickly and simply make competent yeast cells for highly efficient transformations.
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Edward Wallace @ewjwallace.bsky.social · 19/08/2026
Bunsen burners limitations in aseptic technique! Data-driven evidence here in a neat and careful study For what it's worth, the senior author Hannah Gavin is a lovely human who I used to occasionally play music with in Chicago.
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Edward Wallace @ewjwallace.bsky.social · 19/08/2026
Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!
ewallace.github.io
Postdoctoral position in fungal engineering biology
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Edward Wallace @ewjwallace.bsky.social · 14/07/2026
Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...
scholar.google.com
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Edward Wallace @ewjwallace.bsky.social · 14/07/2026
Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...
scholar.google.com
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Reposted by Edward Wallace
Alex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026
If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour...
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Reposted by Edward Wallace
Shiv Grewal @grewalsh.bsky.social · 08/07/2026
Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...
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Mara Duncan @mcduncanlab.bsky.social · 23/06/2026
Yes, I've done this. It's always a delight to work with SGD.
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Edward Wallace @ewjwallace.bsky.social · 24/06/2026
Where are we at on acceptable abbreviations for fluorescent proteins? Like, GFP for green fluorescent protein sure, but is mNG for mNeonGreen too much? Etc? Your strongest opinions and arguments invited.
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Edward Wallace @ewjwallace.bsky.social · 12/06/2026
What's the state of genomes that report on early animal / holozoan evolution? A student project in my lab on evolution of RNA-binding proteins is testing the hypothesis of a gene duplication in early metazoa, we want to look for homologs in in holozoa beyond Monosiga. @jlsteenwyk.bsky.social ?
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Reposted by Edward Wallace
Sophie Mason @sophiemason.bsky.social · 30/05/2026
I worked for UKRI for seven years and in my experience, the short timescales were 100% because of delays in central government. Usually because of delays in sign off by a minister; in the worst cases, due to number 10 comms teams insisting we hold back so the PM could announce it or whatever. 1/3
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IGMM-Montpellier @igmm-montpel.bsky.social · 05/05/2026
Save the date : Seminar by Edward Wallace from the University of Edinburgh on Tuesday 12th May at 11h @ewjwallace.bsky.social @edinburgh-uni.bsky.social
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Edward Wallace @ewjwallace.bsky.social · 29/04/2026
How do fungi grow directionally? We think part of the mechanism involves local translation of mRNA near the tip, especially of cell wall components. Delighted to share our preprint showing that an RNA-binding protein, SsdA/Ssd1, is trafficked to the tip of growing fungal filaments.
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Edward Wallace @ewjwallace.bsky.social · 23/02/2026
I am learning a lot from this debate about the last eukaryotic common ancestor. It's thought-provoking to have competing hypotheses and perspectives argued out there in the open. Here, the two arguments are internally consistent, yet different conclusions... so where's the wrong assumption?
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Edward Wallace @ewjwallace.bsky.social · 23/02/2026
Today's @gautamdey.bsky.social seminar on Evolutionary Cell Biology is mind-blowing in so many ways. Dinoflagellates don't have histones!?!?! And BEAUTIFUL microscopy.
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Reposted by Edward Wallace
The Daum Lab @daumlab.bsky.social · 15/01/2026
We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...
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Reposted by Edward Wallace
Evelina Tutucci @anilevetu.bsky.social · 10/01/2026
Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!
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Edward Wallace @ewjwallace.bsky.social · 09/12/2025
Ugh...
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Reposted by Edward Wallace
Bungo Akiyoshi @bungoakiyoshi.bsky.social · 11/11/2025
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
findaphd.com
Dissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh on FindAPhD.com
PhD Project - Dissecting the molecular mechanism of chromosome segregation in the marine plankton Paradiplonema papillatum at University of Edinburgh, listed on FindAPhD.com
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Alexis Rohou @alexisrohou.bsky.social · 31/10/2025
Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry.
Jane Richardson stands next to the lectern and in front of the title slide of her talk. 30 October, 2025. Slide with the follow text: “The zen of model anomalies. Correct most of them. Treasure the meaningful valid few. Live serenely with the rest!”
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The Daum Lab @daumlab.bsky.social · 29/10/2025
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
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Edward Wallace @ewjwallace.bsky.social · 10/10/2025
We had a great fungal minisymposium yesterday @edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together. Next one January or February TBA: Email me to be added to the email list!
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Reposted by Edward Wallace
Marie Winz @mariewinz.bsky.social · 09/09/2025
Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.
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Javier Santoyo @jsantoyo.bsky.social · 04/09/2025
Translon: a single term for translated regions. #Translation @natmethods.nature.com
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Saccharomyces Genome Database @yeastgenome.bsky.social · 20/08/2025
Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited
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Delma Childers @childerslab.bsky.social · 01/08/2025
New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh. www.biorxiv.org/content/10.1...
biorxiv.org
Antifungal exposure can enhance Candida glabrata pathogenesis
Azole antifungal drugs directly inhibit lanosterol 14-α-demethylase and indirectly affect the expression of metabolic, transmembrane transporter, and cell wall organization genes in fungal pathogens. ...
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Richard Sever @richardsever.bsky.social · 31/07/2025
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
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Edward Wallace @ewjwallace.bsky.social · 31/07/2025
V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation.
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c0nc0rdance @c0nc0rdance.bsky.social · 31/07/2025
I NEED to tell you the story of Tae Heung “William” Kim. He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease. He's a *legal permanent resident* of the United States. And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.
From left to right, Dr. Albert Mulenga, William Tae Heung Kim, Dr. Thu Thuy Nguyen, Dr. Alex Kiarie Gaithuma, Dr Hassan Hakimi and Emily Bencosme Cuevas. Kim is a Texas A&M researcher who was detained in San Francisco last Monday despite being a permanent resident of the United States and a green card holder.

COURTESY OF TEXAS A&M UNIVERSITY
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Edward Wallace @ewjwallace.bsky.social · 30/07/2025
Absolutely loving the random ribosome dreams that appear on the #RNAbiology feed.
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Edward Wallace @ewjwallace.bsky.social · 24/07/2025
Wellcome to bluesky @edinburghbiology.bsky.social - Edinburgh School of Biological Sciences! This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...
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Reposted by Edward Wallace
Robert Arkowitz @robertarkowitz.bsky.social · 23/07/2025
wellcome.org/news/can-bio...
wellcome.org
Can bioimaging build capacity in fungi research? | News | Wellcome
Dr Elizabeth Ballou from the University of Exeter writes about her research on antifungal resistance and how bioimaging could help build capacity in fungal research.
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Reposted by Edward Wallace
Michael Baym @baym.lol · 22/07/2025
It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_ This results in a near-logarithmic overcounting of large molecules!
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Edward Wallace @ewjwallace.bsky.social · 17/07/2025
THERE ARE TRANSMEMBRANE RNAs NOW?!?!?!? rnajournal.cshlp.org/content/31/8...
rnajournal.cshlp.org
Implications for OLE RNA as a natural integral membrane RNA
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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Reposted by Edward Wallace
Wolfgang Huber @wkhuber.bsky.social · 04/07/2025
If you work as an academic and behave like your job can be done by a machine, then you should not have that job.
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Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 02/07/2025
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
rdcu.be
Functional amyloid proteins confer defence against predatory bacteria
Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...
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Biochemical Society @biochemsoc.bsky.social · 02/07/2025
#TLUK25 finishing strong! This morning we heard from those with emerging topics within the Translation field. We would like to thank all attendees for their amazing engagement - we will see you next year.
Audience seated in a conference room listening to a speaker presenting at the Translation UK 2025 event at University of Edinburgh.
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Hee-Kyung Ahn @hee-kyung-ahn.bsky.social · 30/06/2025
@instmolplantsci.bsky.social very own Amy Newell presents her work on shade response in plants and translational regulation at the #TLUK25!! @biochemsoc.bsky.social
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Edward Wallace @ewjwallace.bsky.social · 02/07/2025
Recovering from a wonderful 3 days of translation, ribosomes, post-transcriptional regulation at #TLUK25 the Translation UK conference!
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Edward Wallace @ewjwallace.bsky.social · 27/06/2025
Evidence for Safety of Neurospora Species... Feeling this energy today after a sequence I wanted to synthesize raised a pointless biosecurity flag. pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Evidence for Safety of Neurospora Species for Academic and Commercial Uses
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Edward Wallace @ewjwallace.bsky.social · 18/06/2025
School of Biological Sciences symposium: what a wonderful event. So many good talks, great ideas, great conversations, brings our diverse research community together.
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Centro de Investigaciones Biológicas Margarita Salas (CSIC) @cib-csic.bsky.social · 12/06/2025
#REMINDER #CIBseminars Translation on Demand: Exploring the Role of Ribosome Diversity in Plant Adaptation Catharina Merchante, ISHM La Mayora (Universidad de Málaga) 📅June 12 ⏰12pm
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harvestwoman.bsky.social @harvestwoman.bsky.social · 10/06/2025
Meantime, if your grant proposal has any mention of mRNA, better change it to Transcript that the Ribosome Uses to Make Proteins (TRUMP) because otherwise it's not getting approved.
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Edward Wallace @ewjwallace.bsky.social · 11/06/2025
Where do you draw the boundaries between bioinformatics and Exploratory Data Analysis? In discussion with colleagues, wondering about tools like PyMOL and genome browsers - these are clearly used for exploratory data analysis, but aren't exactly Exploratory Data Analysis a la Tukey / data science.
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 10/06/2025
Published now. doi.org/10.1242/jcs....
doi.org
Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis
Summary: This Hypothesis article proposes that key aspects of meiosis evolved prior to mitosis in ancestral eukaryotes.
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Edward Wallace @ewjwallace.bsky.social · 09/06/2025
Fungi special issue!
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