This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in h...

Cerebrospinal fluid’s compartmentalization remains unclear. Here, the authors show increased CSF-mobility around major cerebral arteries within the surrounding subarachnoid space, suggesting the prese...

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Nature Reviews Immunology, Published online: 22 June 2026; doi:10.1038/s41577-026-01329-8A preprint by Hu et al. shows, in a mouse model of primary tauopathy, that conventional type 1 dendritic cells outside of the central nervous system prime CD8+ T cells against brain-derived antigens, which exacerbate neurodegeneration.

Senescent cell states arise across brain-barrier cell types during development but diverge in duration and function. Endothelial cells and macrophages enter a transient, inflammatory state, whereas choroid plexus epithelial cells maintain a persistent, non-inflammatory state supporting long-term barrier function. These cells are required for brain-barrier formation and function.

Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.

Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

We show that bridging veins accumulate amyloid in mouse models of Alzheimer’s disease and human Alzheimer’s disease specimens, associated with impaired cer

Neuronal protein tracing, unlike CSF tracers, reveals that brain clearance follows a “nearest exit” principle through distinct border immune niches disrupted differently by disease.

A long-overlooked layer of fibroblasts exists inside the choroid plexus of mice and humans, adding complexity to the area’s compartmentalization.

Prinz and colleagues examine the distinct functions and repopulation properties of leptomeningeal and perivascular macrophages that mediate immune responses at brain boundaries.

The Next Generation Leaders program at the Allen Institute aims to support emerging and diverse early-career researchers in bioscience who will contribute to cultivating new ideas to make a broad, tra...

Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...

Nature Neuroscience - Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective...

Verhaege et al. identify a conserved fibroblast barrier population at the base of the choroid plexus that compartmentalizes brain–CSF interfaces and is disrupted by inflammation, revealing a new site ...