Abstract. NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production

Author summary How an individual’s immune system responds to infection is diverse, with multiple factors influencing the disease outcome. One such factor is individuals’ prior exposure to other pathog...

Abstract. Archaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contri

Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA dive...

An international gathering of scientists studying the killer-cell immunoglobulin-like receptors (KIR). It will cover topics such  evolution, immunogen

YouTube video by Society for Immune Polymorphism

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Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re...

CU Anschutz researchers contribute to one of the most inclusive human genome maps created, advancing disease research and precision medicine through groundbreaking genetic diversity insights.

HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, ar...

Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that govern these responses are diverse due to the large number of activating and inhibi...

For Immediate Release: Tuesday, July 29, 2025, 10:00 a.m. U.S. Eastern Time Media Contact: Evelyn Mantegani, (301) 634-7300, press@ashg.org Rockville, Md. – The American Society of Human Genetics (ASH...

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Certain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer...

IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucos…

The Society for Immune Polymorphism is dedicated to understanding the genetic and functional variation of the vertebrate immune system, and the immune system’s role in evolutionary biology, disease and health.

Evidence for disassortative mating based on the human-specific MHC, i.e. HLA, is equivocal1. Initial evidence for disassortative HLA-pairing in the European-descent Hutterites2 has tended not to repli...

New data in The Journal of Immunology uncovered the role of malaria in the development of Burkitt lymphoma, the most common childhood cancer in equatorial Africa and New Guinea.

Abstract. Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA)