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Artemy Kolchinsky

@artemyte.bsky.social
1.5K followers 283 following 33 posts

Researcher studying nonequilibrium thermodynamics, information theory, origin of life, complexity. Currently at Universitat Pompeu Fabra in Barcelona, Spain

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Reposted by Artemy Kolchinsky
Physical Review Letters @physrevlett.aps.org · 28/09/2026
To simplify multiscale systems, scientists often average out fast variables and focus on slow ones. New work shows how this method neglects complex, narrow pathways, or “singular funnels,” and misrepresents systems’ resilience to perturbations. More: go.aps.org/3Tp3dxZ
A color gradient contour plot illustrating a singular basin with a singular funnel. On the right, a large region shaded with an orange-yellow color gradient represents the basin of attraction. It contains a thick black vertical curve labeled ɣc (periodic rotation). This region narrows in the lower half, passing a point on the left edge labeled e2 (saddle equilibrium). In the upper half, the region curves around a white space that contains a black point labeled e1 (stable equilibrium). To the left of this region, five very narrow, deep orange vertical strips extend across white space.
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Artemy Kolchinsky @artemyte.bsky.social · 16/09/2026
Beautiful paper!
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Reposted by Artemy Kolchinsky
Luís M. Rocha @lmrocha.bsky.social · 20/08/2026
Some words about Howard Pattee, expanding a bit my comments last night @alifeconf.bsky.social . heycityzen.substack.com/p/howard-h-p... #ComplexSystems #TheoreticalBiology #ArtificalLife
heycityzen.substack.com
Howard H. Pattee (1926-2026)
It is with a lot of emotion that I applaud the International Society for Artificial Life for honoring the lifetime achievement of Howard Pattee to the field.
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Kate Nave @kathrynnave.eurosky.social · 29/07/2026
My postdoc is coming to an end, so I'm looking for work! Let me know if you, or anyone you know, wants to hire a philosopher of biology/cognition with a knack for cross-disciplinary work, a focus on autonomy + agency, and experience writing for the broader public (10+ yrs in sci/tech journalism).
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Artemy Kolchinsky @artemyte.bsky.social · 28/07/2026
What is the fundamental cost of stochastic oscillators? In a recent PRE, I provide an elementary derivation of a fundamental "dissipation-coherence bound". Builds on work on thermodynamics of limit-cycle oscillators by Santolin-Falasco and Nagayama-Ito journals.aps.org/pre/abstrac...
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Artemy Kolchinsky @artemyte.bsky.social · 13/07/2026
Open postdoc position. Interested in complex systems, dynamical systems, and computational mechanics? With Alexandra Jurgens at INRIA (Bordeaux) recrutement.inria.fr/public/clas...
jobs.inria.fr
Post-Doctoral Research Visit F/M Inferring structure in complex systems
Offre d'emploi Inria
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Artemy Kolchinsky @artemyte.bsky.social · 25/06/2026
I just learned Peter Schuster passed away recently. Peter Schuster was a theoretician who did incredible work on the origin of life, evolutionary dynamics, genotype-phenotype maps, and other topics in theoretical biology. A huge loss.
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Reposted by Artemy Kolchinsky
Melanie Mitchell @melaniemitchell.bsky.social · 08/06/2026
I wrote a piece for the Yale Review on AI and "jagged intelligence". (Note: headline was not written by me.) yalereview.org/article/mela...
yalereview.org
Melanie Mitchell: What We Get Wrong About AI
Melanie Mitchell probes the jagged landscape of AI and its uncertain future.
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Tim Taylor @drtimt.bsky.social · 09/06/2026
I'm so very sad to hear of the passing of Inman Harvey. He was my PhD examiner in 1999 (I'm glad to say he passed it!), and was a mentor, inspiration and friend not just to me but to a whole generation (and more) of Artificial Life researchers. He will be very sorely missed, but his legacy lives on.
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Artemy Kolchinsky @artemyte.bsky.social · 22/05/2026
Very interesting preprint 👇
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Artemy Kolchinsky @artemyte.bsky.social · 05/05/2026
How does phase separation, a key mechanism of equilibrium self-organization, interact with nonlinear nonequilibrium dynamics? In our paper with Jonathan Bauermann and Giacomo Bartolucci @gbart.bsky.social, we look at phase separation in chemical oscillators journals.aps.org/prl/abstrac...
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Artemy Kolchinsky @artemyte.bsky.social · 01/05/2026
Open postdoc with the amazing Sarah Marzen (Scripps College, Claremont, California). Intersection of information theory, biophysics, neuroscience, and machine learning. Please RT theclaremontcolleges.wd1.myworkdayjobs.com/en-US/SCR_C...
theclaremontcolleges.wd1.myworkdayjobs.com
Post-Doctoral Researcher
Claremont, CA Job Posting Title: Post-Doctoral Researcher Job Description: PRIMARY PURPOSE/GENERAL DESCRIPTION: Working with Professor Sarah Marzen, the Post-Doctoral Researcher will serve in an advanced professional research capacity to conduct original scholarly and scientific research relating to the engineering of hybrid adaptive networks. The Researcher will routinely need to apply advanced knowledge in physics, applied mathematics, biophysics, scientific computing, and related fields. DESCRIPTION OF DUTIES AND RESPONSIBILITIES: ESSENTIAL FUNCTIONS: This information is intended to be descriptive of the key responsibilities of the position. The incumbent will primarily be engaged in advanced intellectual and creative professional work requiring specialized academic training and the exercise of discretion and independent judgment. Additional duties may be assigned; any such additional duties will primarily be consistent with the professional nature of the position. Independently des
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Artemy Kolchinsky @artemyte.bsky.social · 30/04/2026
We wrote a perspective piece on future directions & challenges for stochastic thermodynamics. Great collaboration with Jan Korbel, Sarah Loos, Gonzalo Manzano, Rosalba Garcia-Millan, Olga Movilla Miangolarra, Edgar Roldan arxiv.org/abs/2604.26601
arxiv.org
Quo vadis, stochastic thermodynamics?
Stochastic thermodynamics is a framework for describing non-equilibrium processes at the level of fluctuating trajectories, where the state of a system evolves as a stochastic time series,...
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davidasivak.bsky.social @davidasivak.bsky.social · 27/04/2026
Reminder: online Workshop on Stochastic Thermodynamics May 18-22 Registration deadline May 17 Detailed schedule now available: wostmeeting.org/programme/
wostmeeting.org
Programme
Workshop programme is available here: wost7detailedDownload The workshop runs from approximately 3pm to 6:30pm on each day (CEST, or UTC+2).
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Paolo De Los Rios @paolodelosrios.bsky.social · 21/03/2026
Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action.
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Artemy Kolchinsky @artemyte.bsky.social · 14/04/2026
Our paper with Andreas Dechant, Kohei Yoshimura and @ito_sosuke is out in Phys Review Research (journals.aps.org/prresearch/...). We propose a "generalized free energy" for nonequilibrium systems, plus an information-geometric decomposition of dissipation into excess & housekeeping terms
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EckfordLab @eckfordlab.bsky.social · 09/03/2026
I was at the IZS in Zurich last week, a spectacular conference in a beautiful location. I used my invited paper as an opportunity to explain what biological information theory is, and why I think it is important [PDF link]: www.research-collection.ethz.ch/server/api/c...
research-collection.ethz.ch
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Artemy Kolchinsky @artemyte.bsky.social · 07/03/2026
Great post on rationalism versus empiricism in the history of optimal control.
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Quanta Magazine @quantamagazine.org · 25/02/2026
In 1874, Georg Cantor published one of the most important papers in math’s 4,000-year history. The ideas in it were stolen. 🧵
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Artemy Kolchinsky @artemyte.bsky.social · 23/02/2026
Fascinating paper — molecular error correction might not incur an accuracy/speed tradeoff. In fact, it may be favored by evolution simply due to increased speed www.science.org/doi/10.1126/...
science.org
Evolution of error correction through a need for speed
Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...
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John C. Baez @johncarlosbaez.bsky.social · 22/02/2026
Which of these shapes looks like the sound "bouba", and which looks like the sound "kiki"? People of all cultures agree on this, and now it's been found that baby chicks do too: phys.org/news/2026-02... It's called the bouba/kiki effect, and I think it follows from physics! (1/2)
The shape at left is angular, while the shape at right has rounded bulges.  This picture is used as a test to demonstrate that people may not attach sounds to shapes arbitrarily. 

From here:

https://commons.wikimedia.org/wiki/File:Booba-Kiki.svg
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Artemy Kolchinsky @artemyte.bsky.social · 19/02/2026
Our paper w/ @maguilera.net & Sosuke Ito is out in PRL. We combine ideas from stochastic thermodynamics & nonequilibrium Maximum Entropy to quantify forces + dissipation in high-dimensional nonequilibrium systems, including spin glasses and neural data link: journals.aps.org/prl/abstract...
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Lance Fortnow @lance.fortnow.com · 16/02/2026
Joe Halpern passed away Friday at the age of 72. He was a leader in mathematically reasoning about knowledge. www.linkedin.com/pos...
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Institut Natura e Teoria ※ Pireneus (INTP) @intp-science.bsky.social · 28/01/2026
☀️ 2026 Summer School in the Pyrenees - Unifying Mathematical Models of Biodiversity Applications are now open! This school offers a state-of-the-art overview for interdisciplinary theoreticians. 🗓️ July 5-11 🎯 PhD students to senior researchers ℹ️ intp.science/en/summer26.... 📭 contact@intp.science 🌐🧪
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Ricard Solé @ricardsole.bsky.social · 10/02/2026
Can we engineer cognition in aneural systems? What are the challenges and implications? Can synthetic biology be used to interrogate basal cognition? Our new paper with @jordiplam.bsky.social explores these questions using models of minimal gene circuits. Available here pubs.acs.org/doi/pdf/10.1...
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Manlio De Domenico @manlius.bsky.social · 28/01/2026
"In other words, European taxpayers will have spent more on the funding process than on the funding itself, and the scientific ecosystem has been drained" The situation is rapidly becoming unsustainable: the current research funding scheme does not work. www.nature.com/articles/d41...
nature.com
Point of no returns: researchers are crossing a threshold in the fight for funding
With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.
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Artemy Kolchinsky @artemyte.bsky.social · 26/01/2026
A remarkable preprint that shows emergence of active protocells from simple starting conditions
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Origin of Life Early-Career Network @oolen.bsky.social · 12/01/2026
If you work on the origins of life / prebiotic chemistry, consider joining OoLEN 🧬🌍 We’re an early-career community for connecting across disciplines, sharing opportunities, and building momentum together. Join: oolen.org/join (And feel free to reply with what you work on!) #OriginOfLife
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davidasivak.bsky.social @davidasivak.bsky.social · 06/01/2026
Interested in the intersection of nonequilibrium thermodynamics and biophysics? Think Canada might be a nice place for your PhD/postdoc? Talk to me! Brand-new funding opportunity has quick deadline (so likely undersubscribed). nserc-crsng.canada.ca/en/news/laun... SFU internal deadline Feb 11
nserc-crsng.canada.ca
Launch of new Canada Impact+ Research Training Awards
As announced in Budget 2025 -
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Itai Yanai @itaiyanai.bsky.social · 05/01/2026
"Choosing problems is the primary determinant of what one accomplishes in science." 'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists. pni.princeton.edu/document/1136
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Artemy Kolchinsky @artemyte.bsky.social · 20/12/2025
New paper in PRL on the relationship between thermodynamic driving and eigenvalues in Markovian master equations. We prove a weaker version of a beautiful conjecture proposed by Uhl and Seifert. Led by Guo-Hua Xu, with Jean-Charles Delvenne and Sosuke Ito journals.aps.org/prl/abstract...
journals.aps.org
Thermodynamic Geometric Constraint on the Spectrum of Markov Rate Matrices
A thermodynamic constraint is placed on the spectrum of Markov rate matrices, allowing for a better understanding of the dynamics of biochemical clocks.
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Ricard Solé @ricardsole.bsky.social · 19/12/2025
Cooperation is a universal feature of complex systems, from the origins of life and microbiomes to societies. What universal patterns can be found in these systems? Here's our new @pnas.org paper. @jordipinero.bsky.social @artemyte.bsky.social @sfiscience.bsky.social www.pnas.org/doi/epdf/10....
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Complexity Cat 🐱 @amahury.bsky.social · 17/10/2025
The characterization of life as a thermodynamic phenomenon out of equilibrium is usually attributed to Schrödinger. What if I told you that he wasn't the first (not even the second😶‍🌫️) to reach that famous and influential conclusion?/1 #complexitycat🐈‍⬛ amahury.github.io/posts/reinve...
amahury.github.io
When Schrödinger Reinvented the Wheel
Erwin Schrödinger’s “What is Life?” is perhaps one of the most influential works in theoretical biology, but what if I told you that one of the key ideas discussed in it was nothing new?
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Artemy Kolchinsky @artemyte.bsky.social · 07/10/2025
After a long time in the making, my paper on nonequilibrium thermodynamics of Darwinian evolution has been published in Philosophical Transactions B. Updated version: arxiv.org/abs/2112.02809
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Ricard Solé @ricardsole.bsky.social · 02/10/2025
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
royalsocietypublishing.org
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936
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Artemy Kolchinsky @artemyte.bsky.social · 15/09/2025
Possible biosignatures detected on Mars www.nature.com/articles/d41...
nature.com
Did Mars harbour life? One of the strongest signs yet is spotted in a peculiar rock
The intriguing chemistry of a rock collected by the Perseverance rover could trace to microbial activity — or not.
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Artemy Kolchinsky @artemyte.bsky.social · 15/09/2025
Reading this beautiful review of the "cutoff timescale" in Markov chains, the timescale over which a system relaxes from nonequilibrium to equilibrium behavior arxiv.org/abs/2508.21055
arxiv.org
Modern aspects of Markov chains: entropy, curvature and the cutoff phenomenon
The cutoff phenomenon is an abrupt transition from out of equilibrium to equilibrium undergone by certain Markov processes in the limit where the size of the state space tends to infinity: instead of ...
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Ben Recht @beenwrekt.bsky.social · 11/09/2025
This new center strikes the right tone in approaching the AI alignment problem. alignmentalignment.ai
alignmentalignment.ai
Center for the Alignment of AI Alignment Centers
We align the aligners
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Ricard Solé @ricardsole.bsky.social · 10/09/2025
Can a single cell learn? Even without a brain, some microbes show simple forms of cognition. Can this basal cognition be engineered? Check our new paper with @jordiplam.bsky.social on the minimal synthetic circuits & their cognitive limits. @drmichaellevin.bsky.social www.biorxiv.org/content/10.1...
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Artemy Kolchinsky @artemyte.bsky.social · 05/09/2025
Helping to organize this workshop on quantum and stochastic thermodynamics in Kyoto, Japan, Dec 8-12. Resource theory, optimal transport, and more. Submissions open! indico.yukawa.kyoto-u.ac.jp/event/68/
indico.yukawa.kyoto-u.ac.jp
Kyoto Workshop on Quantum Thermodynamics and Stochastic Thermodynamics 2025
Schedule and VenueDecember 8-12, 2025 Panasonic Auditorium, Yukawa Hall, YITP, Kyoto University, JapanScopeRecent advances in physics have increasingly highlighted the need to understand energy conver...
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Adam Frank @adamfrank4.bsky.social · 04/09/2025
Here is our new paper that we're really excited about. What makes a cell different from a rock? The answer we argue is the USE of information. But information carries meaning and that changes everything if we want to understand the "physics of life". journals.aps.org/prxlife/abst...
journals.aps.org
Physics of Life: Exploring Information as a Distinctive Feature of Living Systems
Living systems are defined by their active acquisition and use of information. This Roadmap surveys current research on life's information processes and their importance for the search for life beyond...
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Giacomo Bartolucci (he) @gbart.bsky.social · 01/08/2025
Proud of this preprint with my friends Jonathan Bauermann and @artemyte.bsky.social, about chemical oscillators & phase separation! Main findings: 1. Phase separation controls frequency and amplitude of oscillations 2. If reactions are fast, spirals of droplets emerge! arxiv.org/abs/2507.16030
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Ricard Solé @ricardsole.bsky.social · 12/06/2025
How can we build a general theory of mutualistic communities? After five years, we finally completed a new Neutral Theory of Cooperation that is fully solved analytically and displays remarkable properties @jordipinero.bsky.social @artemyte.bsky.social @manlius.bsky.social arxiv.org/abs/2506.09737
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Artemy Kolchinsky @artemyte.bsky.social · 10/06/2025
We have a new preprint about measuring entropy production in high-dimensional systems, using ideas from information geometry. We successfully infer EP from brain recordings and spin models containing 1000+ degrees of freedom. With @maguilera.net and Sosuke Ito arxiv.org/abs/2505.10444
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Ricard Solé @ricardsole.bsky.social · 31/05/2025
How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore key ideas from evolutionary theory and are seriously flawed. Check this paper in PNAS www.pnas.org/doi/abs/10.1...
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Thomas F. Varley @thosvarley.bsky.social · 23/02/2025
If anyone in the complex systems/computational neuroscience field in Europe is looking to poach an American scientist, I'm interested in what might be out there. My scholar profile: scholar.google.com/citations?hl...
scholar.google.com
Thomas F. Varley
‪Postdoctoral Scientist - Vermont Complex Systems Institute‬ - ‪‪Cited by 871‬‬ - ‪Information Theory‬ - ‪Complex Systems‬ - ‪Synergy‬ - ‪Emergence‬
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Artemy Kolchinsky @artemyte.bsky.social · 21/02/2025
Joint European Thermodynamics Conference, May 26-30, Belgrade, Serbia. Honored to participate in a mini-symposium on stochastic thermo alongside Sarah Loos and Cai Dieball, and other sessions look fascinating. Abstracts due March 15. www.mi.sanu.ac.rs/JETC2025
mi.sanu.ac.rs
JETC 2025
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Artemy Kolchinsky @artemyte.bsky.social · 07/02/2025
TIL that scipost.org publishes several high quality physics journals, all open-access and without any publication fees. Maybe its one way to move beyond the current nightmare of academic publishing....
scipost.org
SciPost Homepage
SciPost homepage
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Santa Fe Institute @sfiscience.bsky.social · 28/01/2025
How do systems—biological or technological—maximize energy harvested from their environments? A new study explores how the initial state of a system impacts free energy gain and extractable work and illustrates the findings through a simple information-engine model. doi.org/10.3390/e27
doi.org
Maximizing Free Energy Gain
Maximizing the amount of work harvested from an environment is important for a wide variety of biological and technological processes, from energy-harvesting processes such as photosynthesis to energy storage systems such as fuels and batteries. Here, we consider the maximization of free energy—and by extension, the maximum extractable work—that can be gained by a classical or quantum system that undergoes driving by its environment. We consider how the free energy gain depends on the initial state of the system while also accounting for the cost of preparing the system. We provide simple necessary and sufficient conditions for increasing the gain of free energy by varying the initial state. We also derive simple formulae that relate the free energy gained using the optimal initial state rather than another suboptimal initial state. Finally, we demonstrate that the problem of finding the optimal initial state may have two distinct regimes, one easy and...
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