AbstractIntroduction. Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8+ T cell–mediated killing. Introducing full-length NLRC5 (N5FL) or

NLRP10 is an atypical member of the NLR family because it lacks a leucine-rich repeat domain at its C-terminus. Here, we show that in human epithelial cells and keratinocytes NLRP10 oligomerises in re...

How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the ...

NLRP10 is an atypical member of the NOD-like receptor (NLR) family because it lacks a leucine-rich repeat domain at its C-terminus. Recently, NLRP10 has been shown to form an inflammasome, however, th...

Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.

Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.

Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...

Cell-autonomous defense encompasses the inherent mechanisms of the cell that allow individual cells to protect themselves from infectious and inflammatory dangers. Recent advancements in the field in…

This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning.

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Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.

Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenito...

Advances in immunology are inherently linked to progress in implementing novel methods as best illustrated by the development of the cre-lox technique that a...

A key mechanism of immune escape from CD8+ T cell-mediated tumor control occurs via downregulation of NLRC5, the IFNγ-induced transcriptional activator of MHC class-I. As NLRC5 deficiency does not abr...

The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointes...

Vom 12.-14. März 2025 lädt die DGE zusammen mit dem Institut für Ernährungs- und Agrarwissenschaften der Martin-Luther-Universität Halle-Wittenberg herzlich zum 62. Wissenschaftlichen Kongress nach Ka...