Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation. ...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in h...

Join us at the Keystone Symposia on Cancer Immunotherapy: Bridging Basic Research and Clinical Translation, January 2027, in Breckenridge, with field leaders!

Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoi...

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract whose genetic basis is only partly resolved because most risk variants identified by genome-wide as...

In this issue of Cell Host & Microbe, Steinberg et al. present a microbial gene atlas of nasopharyngeal swabs in infants with cystic fibrosis and healthy controls using shotgun metagenomic sequencing....

Steinberg et al. generated an infant nasal microbial gene atlas using samples from infants with and without cystic fibrosis. Frequent hypertonic saline inhalation reshapes airway microbiome function, ...

How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt expressi...

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network by which it maintains homeostasis in Th17 cells. They find that TGF-β1 can reverse the glucocorticoid resistance exhibited by both murine and human inflammatory Th17 cells.

How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt expression and function and the blockade of glucocorticoid receptor function. Their study explains how IL-23 locks Th17 cells into an inflammatory disease-promoting state and provides a mechanism that explains steroid resistance in Th17 cells.

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glu...

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis.

Using single-nucleus RNA sequencing and spatial transcriptomics, Jaiswal et al. identify disease-associated cell communities that include aberrant transitional alveolar epithelium and pro-fibrotic fib...

Lee and Wheeler review the interface of neuroimmune interactions, stress, and affective behaviors. They highlight anatomical and cellular mechanisms controlling immune-brain plasticity as well as therapeutic opportunities and new technologies that could be used to modulate and discover relevant pathways.

Mass General Brigham researchers engineered a virus that destroys brain tumor cells while avoiding healthy brain tissue.

The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...

Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...

The enteric nervous system is a vast network of nerves built into the walls of the intestine. A new study adds to accumulating evidence showing that the ENS works closely with the immune system to hel...