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Nils Blüthgen

@molsysbio.bsky.social
1.2K followers 866 following 86 posts

Charité and Humboldt University Berlin, Computational Modelling, Cancer, Signaling

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Nils Blüthgen @molsysbio.bsky.social · 14/09/2026
Someone sends fake emails that look like they are from Hiroaki Kitano (president of the International Society for Systems Biology) asking for help with travel refunds. SPAM gets more sophisticated now with LLMs... I guess it goes to everyone in the field?
Email text of a spam email: 
Dear Nils,

Thank you for your kind reply.

Could you please help me process a payment of 3,650 Euros to a colleague for a research journey Itinerary clearance? The financial officer is currently offline, and my remote network token which is required to authenticate the transfer is unavailable while I am away.
I will guarantee the reimbursement as soon as I return. It's urgent. Kindly let me know if you can assist with this, so I can forward to you the recipient's bank details.

Thank you in advance for your assistance.

Best,
Hiroaki
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Steffen Mau @steffenmau.bsky.social · 06/09/2026
The landslide victory for a far-right party marks a profound turning point. The traditional party system is no longer able to bind people to it or absorb the prevailing public mood. The AfD is winning support with ethnonationalist and chauvinistic positions that exclude large sections of society.
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Nils Blüthgen @molsysbio.bsky.social · 18/07/2026
I guess
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Nils Blüthgen @molsysbio.bsky.social · 16/06/2026
www.tagesspiegel.de/wirtschaft/f...
tagesspiegel.de
Fatale Signale für den Wirtschaftsstandort Hauptstadt: Die Gesundheitsreform schwächt vor allem Berlin
Warum aktuelle Sparmaßnahmen nicht nur Krankenhäuser belasten, sondern auch Forschung, Fachkräfte und Investitionen gefährden – und damit langfristig dem Wirtschaftsstandort schaden.
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Carl T. Bergstrom @carlbergstrom.com · 03/06/2026
1. How common is LLM use in scientific publishing, and how does it vary across field, publisher, journal prestige, author demographics etc.? @kylesiler.bsky.social has new paper in PNAS that addresses this question on a massive scale: 7.3 million papers from Elsevier, PLOS, MDPI, and Frontiers.
pnas.org
The diffusion of large language models in published academic articles | PNAS
Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...
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Gabriel Yoran @yoran.com · 24/05/2026
Königs Worcesterhausen
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Cihan Çelik @cihancelik.bsky.social · 25/03/2026
Der Vorname des mutmaßlichen Täters, der Anlass für die Aktuelle Stunde im Bundestag „Gewalt gegen Frauen“ war, lautet übrigens: „Christian“.
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Ele Willoughby @minouette.bsky.social · 20/03/2026
Happy birthday to 🇨🇦Canadian medical researcher & #biochemist Maud Menten (1879-1960). 👩🏼‍🔬🧪🐡 #histsci Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of
Linocut portrait of biochemist and medical researcher Maud Menten (1879-1960) with the Michalis-Menten equation in blue and a histology image in pinks and purples in the background.
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Admirable Women @admirablewomen.bsky.social · 20/03/2026
Chemist/physician Dr. Maud Menten co-authored the seminal paper 𝘋𝘪𝘦 𝘒𝘪𝘯𝘦𝘵𝘪𝘬 𝘥𝘦𝘳 𝘐𝘯𝘷𝘦𝘳𝘵𝘪𝘯𝘸𝘪𝘳𝘬𝘶𝘯𝘨, 1931. This intro'd the Michaelis–Menten equation (image). It remains a cornerstone of #biochemistry, used in drug design, metabolic studies & enzyme engineering. She was born #OTD in 1879. #WomenInSTEM
A black-and-white historical photograph of Dr. Maud Leonora Menten (1879–1960), the Canadian physician and biochemist who co-developed the Michaelis–Menten equation for enzyme kinetics. Taken in her laboratory (likely at the University of Pittsburgh in the 1910s–1920s), she stands with a serious, focused expression—lips closed, eyes direct and thoughtful—against a backdrop of wooden shelves filled with glass bottles, jars, scientific equipment, and a wire-mesh enclosure. She wears a dark dress with a lace collar, a string of beads, and her hair styled in a neat bun. Superimposed on the image is the Michaelis–Menten equation in white text:v=Vmax⁡[S]Km+[S]v = \frac{V_{\max} [S]}{K_m + [S]}v = \frac{V_{\max} [S]}{K_m + [S]}
This iconic portrait captures Menten during her groundbreaking research in biochemistry and histochemistry, where she helped establish the foundational mathematical model of enzyme-substrate reactions still used today, while overcoming significant gender barriers as one of the first women in Canada to earn both an M.D. and a Ph.D.
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Nils Blüthgen @molsysbio.bsky.social · 16/03/2026
Thrilled to be at the 2nd Bonn conference on mathematical life sciences. Great to see a huge lecture hall full of people at the kickoff of the conference, all working at the interface of maths and biology.
Projection of an intro slide for the conference
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Frau Büüsker @uedio.bsky.social · 07/01/2026
Toll, dass die Berliner Behörden jetzt verstanden haben, wie Cell Broadcast grundsätzlich funktioniert, jetzt vielleicht noch ne Schulung zum sinnvollen Einsatz, danke.
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Einstein Foundation Berlin @einsteinberlin.bsky.social · 07/01/2026
Zell- & Molekularbiologin Kerstin Kaufmann wird Einstein-Prof & bleibt an der @humboldtuni.bsky.social! Durch Koops mit BIMSB, @mpi-mp-potsdam.bsky.social & @igzleibniz.bsky.social vernetzt sie Molekularbiologie, quantitative Modellierung & Bioengineering. www.einsteinfoundation.de/presse/2026/...
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Oded Rechavi @odedrechavi.bsky.social · 29/11/2025
Fig. 6: Mathematical model
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Amrei Bahr @amreibahr.bsky.social · 21/11/2025
Der #Forschungsausschuss des Bundestags tagt nicht mehr öffentlich — das war’s dann mit Tranzparenz wissenschaftspolitischen Handelns auf Bundesebene! Erschwert die Arbeit von Journalist_innen ebenso wie unsere für #IchBinHanna uvm. massiv. @wpk.bsky.social fordert in 1 offenen Brief, das zu ändern:
wpk.org
Offener Brief an die Bundestagsfraktionen von CDU/CSU, SPD, Bündnis 90/Die Grünen und Die Linke zur Rückkehr der grundsätzlichen Öffentlichkeit der Sitzungen des Forschungsausschusses
An die Vorsitzenden der Bundestagsfraktionen von CDU/CSU, SPD, Bündnis 90/Die Grünen und Die Linke Berlin, 19.11.2025 Öffentlichkeit im Bundestagsausschuss für Forschung, Technologie, Raumfahrt und T...
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Eva Murašov @evamurasov.bsky.social · 19/11/2025
Die Charité-Chefs haben am Montag im Berliner Wissenschaftsausschuss die Folgen der Kürzungen für die Uniklinik skizziert. "Drittmittel werden sinken, Ambulanzen müssen schließen“, fasste Dekan Joachim Spranger es zusammen. (T+) www.tagesspiegel.de/wissen/chari...
tagesspiegel.de
Charité-Chef Heyo Kroemer über Kürzungsfolgen: „Bei keinem Uniklinikum in Deutschland wird derart gespart“
56 Millionen Euro weniger Zuschüsse bekomme das Berliner Uniklinikum 2026, sagt Charité-Chef Kroemer. Das wird sich auf Berlins medizinische Versorgung auswirken – und könnte die Spitzenstellung in de...
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Nils Blüthgen @molsysbio.bsky.social · 17/11/2025
Welcome our new colleagues: Prof. Flasche aus Ede and Prof. Geschirrschwämme! Looking forward to working with you!
Bill from DM
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Nils Blüthgen @molsysbio.bsky.social · 15/11/2025
I always wanted to join the editorial board for an agricultural journal. Clearly my expertise. Will be a great journal 🤡 #scientificspam
Email: Dear Nils Blüthgen,
Cureus Journals, a part of Springer Nature, will be launching its fourth open access journal—Cureus Journal of Agriculture and Food Science (CJAF)— in December 2025. 
 
I would like to take this opportunity to invite you to apply for a position on our esteemed Editorial Board as an Associate Editor (AE) for CJAF.
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Nils Blüthgen @molsysbio.bsky.social · 06/11/2025
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine. www.tagesspiegel.de/berlin/senat...
tagesspiegel.de
Senat will 12,5 Millionen Euro investieren: NFL kommt 2025 für ein Spiel nach Berlin
Die nordamerikanische Football-Liga NFL wird 2025 ein Spiel in Berlin austragen. Bis 2029 könnten zwei weitere Folgen. Die Kosten dafür sind hoch. Das Land muss trotz Haushaltskrise Millionen investie...
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Nils Blüthgen @molsysbio.bsky.social · 06/11/2025
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
Email: Hi Professor Nils Blüthgen,

My name is xxx yyy, I am a PhD student passionate about economics and entrepreneurship. I came across your work “Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network”, a piece that truly stands out for its precision and contribution to society in the field of finance.
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Edda Schulz @eddaschulz.bsky.social · 06/10/2025
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial
nature.com
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
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Jeremy Berg @jeremymberg.bsky.social · 29/09/2025
When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety Who knows what will happen now Just in case, remember Euruope-PMC (europepmc.org )
media.tenor.com
a cartoon of donald trump with the words be prepared above him
ALT: a cartoon of donald trump with the words be prepared above him
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Nils Blüthgen @molsysbio.bsky.social · 04/10/2025
The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...
aerzteblatt.de
Wissenschaftliche Resilienz: Auf dem Weg aus der PubMed-Abhängigkeit – Deutsches Ärzteblatt
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CompCancer PhD programme @compcancer.bsky.social · 26/09/2025
Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.
Nicky McGranahan
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CompCancer PhD programme @compcancer.bsky.social · 26/09/2025
Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!
Students discussing at posterImpression of the poster session at bimsb, showing the staircase Students discussing at poster
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CompCancer PhD programme @compcancer.bsky.social · 25/09/2025
Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!
Tancredi MassimoAdila ApsaraSiddharth Annaldasula
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CompCancer PhD programme @compcancer.bsky.social · 25/09/2025
Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.
Efrat Shema
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CompCancer PhD programme @compcancer.bsky.social · 24/09/2025
Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.
Finja Becker introducing Sven Nelander
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CompCancer PhD programme @compcancer.bsky.social · 24/09/2025
We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!
Ido AmitAnton Henssen
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CompCancer PhD programme @compcancer.bsky.social · 24/09/2025
First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.
Ulrich KeilholzHeiko Enderling
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CompCancer PhD programme @compcancer.bsky.social · 24/09/2025
Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!
Foto of the kickoff and welcome.
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Markus Landthaler @landthalerm.bsky.social · 12/09/2025
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
cell.com
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...
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Nils Blüthgen @molsysbio.bsky.social · 08/09/2025
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
Poster of CompCancer Seminar Series
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Humboldt-Universität zu Berlin @humboldtuni.bsky.social · 26/08/2025
Spatenstich für den Forschungsneubau Optobiologie an der #HumboldtUni. Gemeinsam mit der Charité und der @berlinualliance.bsky.social entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉 www.hu-berlin.de/de/pr/nachri...
Beim Spatenstich (v.l.n.r.): Dr. Ina Czyborra, Senatorin für Wissenschaft, Gesundheit und Pflege, Prof. Dr. Julia von Blumenthal, Präsidentin der Humboldt-Universität zu Berlin, Christian Gaebler, Senator für Stadtentwicklung, Bauen und Wohnen und Prof. Dr. Heyo K. Kroemer, Vorstandsvorsitzender Charité - Universitätsmedizin Berlin. Foto: Stefan Klenke
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Nils Blüthgen @molsysbio.bsky.social · 19/08/2025
Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly @astaburuaga-garcia.bsky.social ) could contribute a bit. Congratulations @sawitzkilab.bsky.social and @woodenrobo.bsky.social to this great paper!
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Nils Blüthgen @molsysbio.bsky.social · 19/08/2025
Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him. www.cell.com/developmenta...
cell.com
Ben-Zion Shilo (1951–2025)
Ben-Zion Shilo, a distinguished Israeli geneticist (Figure 1), passed away this April at the age of 73 at his home in Rehovot. Benny, as he was known to his friends and colleagues around the world, ma...
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Sawitzki Lab @sawitzkilab.bsky.social · 19/08/2025
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Sawitzki Lab @sawitzkilab.bsky.social · 19/08/2025
Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19! 🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
cell.com
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...
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Leif Erik Sander 🇪🇺🇺🇦 @sanderlab.bsky.social · 07/08/2025
Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU
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Nils Blüthgen @molsysbio.bsky.social · 01/08/2025
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
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Nils Blüthgen @molsysbio.bsky.social · 01/08/2025
Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025
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Nils Blüthgen @molsysbio.bsky.social · 25/07/2025
Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
Picture of an email, starting with Greek letters, followed by Desr Dr. {{Ladt Name}}
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Nils Blüthgen @molsysbio.bsky.social · 22/07/2025
Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...
science.org
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer
A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.
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Nils Blüthgen @molsysbio.bsky.social · 22/07/2025
Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...
science.org
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer
A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.
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Nils Blüthgen @molsysbio.bsky.social · 10/07/2025
Dear Professor [Last Name]...
Foto of an email: Dear Professor [Last Name], I hope you are well...
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Stephan Beirer @beirer.bsky.social · 04/07/2025
I studied physics, theoretical biophysics and was involved in the emerging field (around 2005) of systems biology - this paradigm of @proffeynman.bsky.social always astonished me. Still.
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Nils Blüthgen @molsysbio.bsky.social · 24/06/2025
Join ICSB2025 in Dublin: The late-breaking abstract deadline has been extended to August 1st (for oral presentation) and September 1st (for posters). Hope to see you in Dublin! icsb2025.com
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Freie Universität Berlin @freieuniversitaet.bsky.social · 23/06/2025
Vom 23. bis 29. Juni streicht die #FUBerlin das "E", um zu zeigen, was fehlt, wenn Substanz gestrichen wird. Allein für 2025 sollen die Kürzungen rund 37 Million n uro betragen. D r B rlin r S nat g fährd t damit L hr, Forschung und Zukunftssich rh it. All Infos ➡️ tinyurl.com/aktionswoche...
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Nils Blüthgen @molsysbio.bsky.social · 17/06/2025
Tomorrow (Wednesday) is abstract deadline, so send your abstract quickly!
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Simone Reber @simonereber.bsky.social · 13/06/2025
✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
rdcu.be
Cell state-specific cytoplasmic density controls spindle architecture and scaling
Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...
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Nils Blüthgen @molsysbio.bsky.social · 13/06/2025
5 more days to submit abstracts for International Conference on Systems Biology #ICSB2024! Hope to meet you in Dublin!
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