McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.

The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Des…

The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

Structural analysis reveals species-specific differences in how the antibody IgE binds to its receptor FcεRI.

The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells compris...

The gut commensal protist Tritrichomonas musculis (T.mu) boosts T cell–dependent IgA. T.mu-driven IgA modifies the commensal bacterial microbiota and impro

Antigen-specific B cells constitute a small proportion of the total B cell population, making identification for downstream analysis challenging. Here, this is achieved by pairing fluorescent antigen ...