iiinova — where your digital self keeps evolving

Reposted by Joshua McGrath

Waggoner Lab @labwaggoner.bsky.social · 11/03/2026

Imprinting by influenza virus infection in children can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes @nature.com @weillcornell.bsky.social www.nature.com/articles/s41...

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Joshua McGrath @joshuamcgrath.bsky.social · 07/08/2025

Thanks @airr-community.bsky.social for the invitation to share our work on codon optimality in immunoglobulins! www.cell.com/molecular-ce... www.youtube.com/watch?v=WSku...

youtube.com

AIRR C Seminar Series, June 26, 2025 Joshua McGrath, Weill Cornell Medicine, United States

YouTube video by AIRR Community

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Joshua McGrath @joshuamcgrath.bsky.social · 07/01/2025

Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics www.science.org/doi/10.1126/...

science.org

Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein

The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfC...

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Reposted by Joshua McGrath

Eric Topol @erictopol.bsky.social · 31/12/2024

Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity www.pnas.org/doi/10.1073/... @pnas.org

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