Sign in

Kari Hoffman

@karihoffman.bsky.social
2.5K followers 215 following 141 posts

neuroscientist @vanderbilt studying neural circuit+population rules for creating and deploying knowledge. computational neuroethology.

PostsRepliesMedia
Kari Hoffman @karihoffman.bsky.social · 08/09/2026
📣Say it louder for the labs in the back.
072
Reposted by Kari Hoffman
The vOICe vision BCI 🧠🇪🇺 @seeingwithsound.bsky.social · 29/08/2026
United States: Amid funding uncertainty, neuroscientists report a mix of cynicism, persistence www.thetransmitter.org/funding/amid... by @emilysingerneuro.bsky.social with @nicolecrust.bsky.social @sharenarice.bsky.social
thetransmitter.org
Amid funding uncertainty, neuroscientists report a mix of cynicism, persistence
Two years into one of the most tumultuous tenures in U.S. federal funding, researchers outline how they are coping with ongoing changes and reflect on the impact these changes are having on the system...
082
Kari Hoffman @karihoffman.bsky.social · 20/08/2026
🔄 Uno reverse alert, PFC-HPC folks! This throws a spanner in the works of the simple “reuniens as relay” to hippocampus! 🏅Well crafted study. (Shoutout to my student @noahwillhite.bsky.social for tipping me off to it)
0130
Reposted by Kari Hoffman
Cory Inman @brainscout.bsky.social · 14/08/2026
Excited to share our lab's recent paper showing that direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes. The article is open-access, and we'd love to hear your thoughts! Please share! TY to everyone involved! www.nature.com/articles/s42...
46320
Kari Hoffman @karihoffman.bsky.social · 14/08/2026
🙌 ❤️🔥Yes to all the things. The 1st and 4th points may be related. Less about minimizing a reward error term and more about maximizing efficiency, allostasis.
140
Reposted by Kari Hoffman
Ben Hayden @benhayden.bsky.social · 13/08/2026
New paper from the BCM Neurosurgery research team! "Neural basis of compositional control" led by @assiachericoni.bsky.social and @justfineneuro.bsky.social ! 🧵 www.nature.com/articles/s41...
nature.com
Neural basis of compositional control - Nature
Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating p...
39546
Kari Hoffman @karihoffman.bsky.social · 14/08/2026
There is nothing either good or bad, but joking makes it so - Bob untucks humor #bb28
050
Kari Hoffman @karihoffman.bsky.social · 10/08/2026
Can’t overstate this:
040
Reposted by Kari Hoffman
Matteo Carandini @carandinilab.net · 31/07/2026
The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell. A causal spatial role for apical dendrites in the cortex www.biorxiv.org/content/10.6... by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social
A cartoon providing a graphical summary of the paper. It is divided in 3 rows.

The top row shows a pyramidal cell and its apical tuft, and shows the two experiments that we ran: optical dendritic pruning (chopping off the apical tuft), and synaptic imaging done in the same neurons where we do somatic imaging. 

The middle row shows the results pertaining to neurons that prefer large stimuli (this is visual cortex): pruning reduced their responses, and the receptive fields of apical synapses are far away from the that of the soma. 

The bottom row shows the results pertaining to neurons that prefer small stimuli: pruning seemed to do nothing to the responses, and the receptive field of apical synapses are right around that of the soma.
17427
Kari Hoffman @karihoffman.bsky.social · 31/07/2026
G-wiz
000
Reposted by Kari Hoffman
Mark Histed @markhisted.org · 31/07/2026
Also, science needs to care about journalism too! The collapse of the US journalism industry (which is related to conspiracies and fractionation but not the only cause) is also a reason we are here.
2124
Kari Hoffman @karihoffman.bsky.social · 30/07/2026
📣New paper! How does the sleeping brain help us to integrate new experiences while managing memories from the past? For his PhD work, @sabbaspoor.bsky.social recorded hippocampal ensembles in freely moving monkeys and found something unexpected. 🧵1/n www.nature.com/articles/s41... 🧪🧠📈👩‍🔬#OpenAccess
nature.com
Experience reorganizes content-specific memory traces in macaques - Nature Neuroscience
In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometim...
410340
Reposted by Kari Hoffman
Danielle Beckman @daniellebeckman.bsky.social · 29/07/2026
One more nail in the coffin of the "it's just deconditioning" hypothesis. 60 days of strict bed rest ≠ #LongCOVID or #MECFS. Rob's group shows that while exercise capacity may be similarly reduced, the underlying skeletal muscle biology is VERY different. Time to move beyond outdated assumptions.
Nature Communications
Article in Press
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
212955
Reposted by Kari Hoffman
Helen Barron @helencbarron.bsky.social · 28/07/2026
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
biorxiv.org
Generative replay across hippocampal-neocortical circuits
To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...
413463
Reposted by Kari Hoffman
Reza Shadmehr @rezashadmehr.bsky.social · 28/07/2026
If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...
biorxiv.org
Climbing fibers encode the gradient of a loss function for the cerebellum
Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...
218170
Reposted by Kari Hoffman
Biyu Jade He @biyuhe.bsky.social · 09/07/2026
New paper alert from our lab! nature.com/articles/s41... We used stimuli sequences following 1/f statistical patterns—an ubiquitous statistical structure in natural stimuli—to probe predictive processing in the human brain. How does the brain predict upcoming sensory inputs based on past inputs?
nature.com
Neural mechanisms of time-forward predictions for naturalistic auditory tone sequences - Nature Communications
A longstanding question is how the brain predicts complex, naturalistic sensory events and updates those predictions when expectations are violated. Using intracranial recordings, the authors show tha...
13313
Reposted by Kari Hoffman
Per Axbom @axbom.com · 10/07/2026
Olivia Guest is my favorite person to follow when it comes to calling out AI hype based on a deep and thoughtful understanding of it. This point is so very important. It's ok not to know things. #FollowFriday
1286
Reposted by Kari Hoffman
Danielle Beckman @daniellebeckman.bsky.social · 10/07/2026
Most people who develop #dementia don't have a family history of the disease. Interactions between vascular health, metabolism, environmental exposures, and *increasingly* pathogens also play a role. Brain aging starts decades before symptoms appear. 🧠 www.nature.com/articles/d41...
nature.com
How to avoid dementia — what the science really says
Ambitious studies have been examining the protective effects of diet, exercise and socializing — with surprising results.
27921
Reposted by Kari Hoffman
Oscar Chadney @oscar-chadney.bsky.social · 09/07/2026
I’m excited to share our latest preprint, and the main work from my PhD, on the role of the direct entorhinal input in hippocampus CA1 spatial coding. 1/9
13617
Reposted by Kari Hoffman
Morgan Barense @barense.bsky.social · 09/07/2026
Check out our @royalsociety.org Philosophical Transactions B theme issue, "The role of hippocampal prediction: bridging perception and memory." Thanks to all our fabulous authors, and my co-editors @peterkok.bsky.social and @mariamaly.bsky.social who dreamed it up and kept the train on the tracks.
1196
Reposted by Kari Hoffman
Phil Williams @philinvestigates.com · 18/03/2026
A very personal story that I have kept to myself for four months posts tomorrow morning to HateComesToMainStreet.com. Subscribe now to get immediately notified.
hatecomestomainstreet.com
Hate Comes to Main Street | Phil Williams | Substack
Examining the influence of white supremacists, neo-Nazis, Christian nationalists, and QAnon conspiracy theorists on Main Street America. Click to read Hate Comes to Main Street, by Phil Williams, a Su...
019148
Reposted by Kari Hoffman
Pablo Fernandez Velasco @pfvelasco.bsky.social · 16/03/2026
Here is a brief overview of existing approaches to studying "real-world" navigation. Really happy to have worked on this with @hugospiers.bsky.social & @antoinecoutrot.bsky.social! arxiv.org/pdf/2603.11347
0104
Reposted by Kari Hoffman
Jonathan Pillow @jpillowtime.bsky.social · 17/12/2025
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists. arxiv.org/abs/2512.12467
arxiv.org
Reduced rank regression for neural communication: a tutorial for neuroscientists
Reduced rank regression (RRR) is a statistical method for finding a low-dimensional linear mapping between a set of high-dimensional inputs and outputs. In recent years, RRR has found numerous applica...
211338
Reposted by Kari Hoffman
Juan Gallego @juangallego.bsky.social · 13/12/2025
let's talk in person! but fwiw I personally think that we talk about dimensionality! to me the important ideas within the neural manifold framework are: (1) manifolds reflect biological constraints, (2) capture population-wide functions/computations, (3) manifolds (may) have ontological power
471
Kari Hoffman @karihoffman.bsky.social · 13/12/2025
🤩 + impressive answer 🧭🚕 @ 2:50 “Trust me, knowledge is power” 💀 This is my guy.
131
Reposted by Kari Hoffman
Mark Histed @markhisted.org · 13/12/2025
Good resp to Bhattacharya, noting the agenda of The Spectator. When we rebut Trump attacks on science it’s good to talk about his agenda and the agenda backing him—he was selected for the job by donors who want to privatize federal funding and use science as a wedge issue to get votes for thr side.
33513
Reposted by Kari Hoffman
hakwan lau @hakwan.bsky.social · 13/12/2025
www.science.org/doi/10.1126/... damn this is so very clever! "... we investigated how the brain categorizes stimuli that are not linearly separable in the physical world ... The sensory manifold was ... expanded into a seven-dimensional perceptual manifold..."
science.org
From sensory to perceptual manifolds: The twist of neural geometry
The brain uses geometric twists to expand neural dimensionality, thus untangling perception from sensation.
1709
Kari Hoffman @karihoffman.bsky.social · 13/12/2025
Human multipatch L2/3 functional cell types. LFG. 🧠📈🧪
0163
Reposted by Kari Hoffman
Amanda Katz @katzish.bsky.social · 13/12/2025
Tolerance has gone too far. Researchers should date other people, in my opinion
71439
Reposted by Kari Hoffman
Ben Hayden @benhayden.bsky.social · 12/12/2025
Landmark paper from @srheilbronner.bsky.social and colleagues! www.cell.com/trends/neuro...
cell.com
Reconstructing the human brain’s wiring diagram from axons up
The human brain’s long-range axonal connections are the scaffolding for communication across functionally distinct areas. Yet knowledge of the human brain’s wiring diagram remains limited, largely due...
0162
Kari Hoffman @karihoffman.bsky.social · 12/12/2025
Last day to register for the 50th anniversary meeting Jan 8-11: parkcitywinterconf.org/register/ Historical perspectives from Lynn Nadel, Os Steward, Jim McClelland, and topics from synaptic plasticity to neural circuit dynamics of learning and memory systems to aging and dementia. #neuroskyence
parkcitywinterconf.org
Register – Park City Winter Conference
040
Kari Hoffman @karihoffman.bsky.social · 12/12/2025
Nice thread (and nice recognition for @trackingactions.bsky.social!)
120
Reposted by Kari Hoffman
Juan Gallego @juangallego.bsky.social · 12/12/2025
We give examples for less striking number of neurons here. For different species, tasks, and brain areas, it's always the same observation: PCA overestimates the dimensionality -except for one very simple task- and this overestimate gets worse w the number of neurons www.biorxiv.org/content/10.1...
biorxiv.org
Nonlinear manifolds underlie neural population activity during behaviour
There is rich variety in the activity of single neurons recorded during behaviour. Yet, these diverse single neuron responses can be well described by relatively few patterns of neural co-modulation. ...
3174
Kari Hoffman @karihoffman.bsky.social · 11/12/2025
📣Register now for the 50th Anniversary Park City Winter Conference on the Neurobiology of Learning and Memory parkcitywinterconf.org/register/ Deadline tomorrow, Friday, the 12th! Spread the word. 🧠🔬👩‍🔬 ➡️Top 5 reasons to attend: 1/6
meeting logo
173
Kari Hoffman @karihoffman.bsky.social · 22/11/2025
correction: he *is* reviewer #3
120
Reposted by Kari Hoffman
Danielle Beckman @daniellebeckman.bsky.social · 22/11/2025
Keep in mind, we could have already advanced so much in this field if, for political reasons, mRNA vaccines were not severely attacked over the past 5 years. We are closer than ever to a cure for #MultipleSclerosis, and that involves preventing #EBV from damaging the brain.
independent.co.uk
Common virus jab could be key in fight against multiple sclerosis
The vaccine will be trialled in patients recently diagnosed with MS
312638
Reposted by Kari Hoffman
Laura Dugué @lauradugue.bsky.social · 19/11/2025
🚨New publication! I am extremely happy to share this new review article in elife on #Traveling_Waves! @erc.europa.eu @upcite.bsky.social elifesciences.org/articles/106...
elifesciences.org
Traveling waves across scales: Different mechanisms but same canonical computation?
The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computationa...
37625
Reposted by Kari Hoffman
Mark Histed @markhisted.org · 19/11/2025
I wrote this last week with the news of the shutdown deal, about why we need a lot more to save US science. Comments and questions are welcome. ------------------- As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/
171
Kari Hoffman @karihoffman.bsky.social · 17/11/2025
Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒
Poster presentation
171
Reposted by Kari Hoffman
john sakon @johnsakon.bsky.social · 15/11/2025
For those coming to SfN, I’ll be giving a talk showing evidence of hippocampal neuronal replay 🎞️🔁 in HUMANS as part of the “Representation of Time in the Brain” minisymposium (Wednesday morning) Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025 🧠
jneurosci.org
Neural Representation of Episodic Time
Inspired by recent discoveries of neural populations that track time for specific moments (time cells) and elapsed durations (temporal context and periodic time cells), this review, based on a minisym...
2449
Reposted by Kari Hoffman
Theresa Desrochers, Ph.D. @desrocherslab.bsky.social · 16/11/2025
Good morning #SfN25! Looking for some posters to see this afternoon? Check out two by our lab: GG15 and HH1 🧠🧪👩🏻‍🔬
0103
Reposted by Kari Hoffman
Stefan Treue @stefantreue.bsky.social · 16/11/2025
Make sure to add this event to your #sfn25 schedule 👇 #animalResearch #transparency #neuroscience
031
Reposted by Kari Hoffman
Nicole Rust @nicolecrust.bsky.social · 16/11/2025
Sad to miss the rest of this session, but excited to go meet with the brainfacts.org team. We have a lot of exciting new results in brain/mind research to unpack (yeah!) as well as a disturbing amount to misinformation to combat (sigh). If you aren’t following @brainfacts.org, you must!
brainfacts.org
BrainFacts
041
Reposted by Kari Hoffman
Vinny Costa @vincentcostaphd.bsky.social · 16/11/2025
How our foray into acute neural recordings from the frontopolar cortex started. Check out Kati Rothenhoefer’s LBP028 poster this afternoon (11/16) to learn about how it’s going. #sfn25 #sfn2025
0238
Reposted by Kari Hoffman
Nima Dehghani @neurovium.bsky.social · 16/11/2025
Come hear about state-driven neural complexity today #SfN25 PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability" Poster Session 1-5 pm Computational Approaches & Experimental Analyses I
media.tenor.com
a man in a star trek uniform is sitting in front of a control panel
ALT: a man in a star trek uniform is sitting in front of a control panel
031
Reposted by Kari Hoffman
allen institute @alleninstitute.org · 15/11/2025
🧬 Evolution meets neuroscience at #SfN25! Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species. 📅 Tues., 11/18, 9:30am–12:00pm 📍 Rm 6CF 📲 www.abstractsonline.com/pp8/#!/2117…
051
Reposted by Kari Hoffman
Mark Histed @markhisted.org · 15/11/2025
And I’m a big fan of Turing, von Neumann, Shannon, Metcalfe, Hinton, Sejnowski, and all the other algorithmic and computation people. No shade. But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.
2344
Reposted by Kari Hoffman
Mike Yassa @mikeyassa.bsky.social · 15/11/2025
Landed at #SfN and we have lots of fun new results to share. See below for Yassalab poster presentations. If you want to talk #Alzheimers or #mentalhealth come chat with us. #SfN25 #neurosky #neuroskyence #academicchatter
0347
Reposted by Kari Hoffman
Mark Histed @markhisted.org · 14/11/2025
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers. I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research. As @jenna-m-norton.bsky.social put well: 1/
328399
Reposted by Kari Hoffman
Carlos Brody @carlosbrody.bsky.social · 15/11/2025
@markhisted.org , you have been and are incredibly brave and admirable. I hope the rumors are false. and: keep up the amazing work!
0186