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Jun Ishigohoka

@junishigohoka.bsky.social
227 followers 280 following 80 posts

Evolutionary biologist. Phenotypic noise < bird migration genomics Tübingen < Plön < Kiel < Sapporo < Tokyo junishigohoka.github.io

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Reposted by Jun Ishigohoka
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 10/10/2026
Weak selection of phenotypic memory in periodic environments www.biorxiv.org/content/10.64898/20…
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Reposted by Jun Ishigohoka
Eric Topol @erictopol.bsky.social · 08/10/2026
New @science.org A breakthrough in understanding why do we get fever and an inflammation response to vaccines. The gut microbiome chronic production of flagellin Paves the way to potentially prevent these acute phase side-effects in the future www.science.org/doi/10.1126/...
science.org
The human gut microbiome primes fever after vaccination
Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temper...
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Jun Ishigohoka @junishigohoka.bsky.social · 30/09/2026
www.nature.com/articles/s41...
nature.com
Butterfly wing patterns in flight create powerful illusory motion cues - Nature
Butterfly wing patterns and flight dynamics work in tandem to create powerful visual illusions that confuse predators, potentially representing one of the most successful visual defence strategies in ...
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Jun Ishigohoka @junishigohoka.bsky.social · 29/09/2026
www.nature.com/articles/d41...
nature.com
Brain lipids are organized into zones — and reorganized during pregnancy
A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in gene-expression and protein atlases.
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Jun Ishigohoka @junishigohoka.bsky.social · 29/09/2026
cell.com
Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
Vaughen et al. find that brain sphingolipids are degraded by glial-derived glucocerebrosidase (GBA). Glial gba1b knockout in Drosophila causes selective sphingolipid and phospholipid alterations, cycl...
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Jun Ishigohoka @junishigohoka.bsky.social · 28/09/2026
www.nature.com/articles/s41...
nature.com
Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population - Nature Ecology & Evolution
Species persistence following hybridization in nature requires the purging of introgressed alleles. Genomic monitoring of a tsunami-induced hybrid stickleback population in Japan reveals rapid genome-...
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Reposted by Jun Ishigohoka
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 24/09/2026
Somatic differentiation evolves rapidly and repeatedly through the modification of developmental plasticity www.biorxiv.org/content/10.64898/20…
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Reposted by Jun Ishigohoka
Aaron Ragsdale @apragsdale.bsky.social · 20/09/2026
Now out in Genetics: academic.oup.com/genetics/adv...
academic.oup.com
Mean fitness is maximized in small populations under stabilizing selection on highly polygenic traits
Abstract. Stabilizing selection commonly acts on complex traits that affect individual fitness. Here, we relate mean fitness under stabilizing selection to
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Jun Ishigohoka @junishigohoka.bsky.social · 18/09/2026
dx.plos.org/10.1371/jour...
dx.plos.org
Circadian Remodeling of Neuronal Circuits Involved in Rhythmic Behavior
The circadian clock controls a wide array of biological phenomena ranging from basal transcription to overt behavior. Now, new evidence shows that the clock affects a striking remodeling of the circui...
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Jun Ishigohoka @junishigohoka.bsky.social · 18/09/2026
www.ovid.com/journals/dev...
ovid.com
Circadian Changes in Drosophila Motor Terminals : Developmental Neurobiology
ABSTRACT:InDrosophila melanogaster,as in most other higher organisms, a circadian clock controls the rhythmic distribution of rest/sleep and...
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Reposted by Jun Ishigohoka
Nature Portfolio @natureportfolio.nature.com · 05/09/2026
The recently extinct Tasmanian tiger was Australia’s largest marsupial predator and famously likened to dog-family carnivorans. A study in Nature Communications shows that its skull functioned differently in prey capture compared to any living mammalian carnivore. go.nature.com/4r10OFZ #evosky 🧪
This is figure 1, which shows principal component plots of all partition shapes.
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Reposted by Jun Ishigohoka
Haoran Cai @haorancai.bsky.social · 27/08/2026
Now out @molbioevol.bsky.socialGenetic correlations summarize how traits covary, but they can hide different underlying architectures. Distinguishing those architectures can reveal distinct mechanisms generating—and potentially constraining—trait–trait relationships. academic.oup.com/mbe/advance-...
academic.oup.com
Consistent and idiosyncratic pleiotropy in shaping genetic correlations
Abstract. Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evoluti
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Reposted by Jun Ishigohoka
Ken Miller @kenmiller.bsky.social · 26/08/2026
This is wild. >1/2 of HC synapses disappear in artificial hibernation, come back in same/similar locations & memories intact. ~1/2 of engram synapses-between two memory-tagged cells-are clustered on dendrites, those preferentially spared. Not biggest synapses. 1/ www.science.org/doi/10.1126/...
This shows the visual abstract and a paragraph from the extended abstract of the linked article.
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Reposted by Jun Ishigohoka
Journal of Evolutionary Biology @jevbio.bsky.social · 25/08/2026
Does habitat use drive morphological variation in snakes? Our new study of over 400 species shows how distinct environments shape head and body traits, revealing a complex balance between adaptation and specialisation 🐍 Hudry & Herrel 2026 #Ecomorphology #SnakeEvolution doi.org/10.1093/jeb/...
doi.org
From head to tail: Does habitat use drive morphological variation in snakes?
Abstract. Convergence, defined as lineages evolving to be more similar to one another than their ancestors due to selective pressures is a hallmark of adap
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Reposted by Jun Ishigohoka
Timothy Fuqua 🏳️‍🌈 @timothyfuqua.bsky.social · 19/08/2026
@vakirlis.bsky.social and I are proposing a new term in the de-novo genes / molecular evolution cinematic universe. The term is: "Emergence Bias" and our perspective piece describing it was published in @genomebiolevol.bsky.social today! So, what is an emergence bias? (1/7)
academic.oup.com
Emergence Biases in Molecular Evolution
Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d
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Reposted by Jun Ishigohoka
Genome Biology and Evolution @genomebiolevol.bsky.social · 24/08/2026
@timothyfuqua.bsky.social & @vakirlis.bsky.social formalize “emergence bias” as the molecular predisposition that, upon mutation, biases a genetic sequence toward or against manifesting new or latent functions or phenotypes 🔗 academic.oup.com/gbe/article/... #societyjournal #genome #evolution
academic.oup.com
Emergence Biases in Molecular Evolution
Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d
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Reposted by Jun Ishigohoka
Nature @nature.com · 22/08/2026
“It’s the best thing that has ever happened to me” - this is the first approved drug designed to treat the cause of narcolepsy go.nature.com/4hMj3fL
go.nature.com
First-of-its-kind narcolepsy drug opens door to new therapies for the brain
Nature - The drug, called Orzeyful, takes aim at the root cause of the sleep disorder rather than at its symptoms.
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Jun Ishigohoka @junishigohoka.bsky.social · 21/08/2026
Social behavior and activity are decoupled in larval and adult fruit flies academic.oup.com/beheco/artic...
academic.oup.com
Social behavior and activity are decoupled in larval and adult fruit flies
Lay Summary. The adaptive decoupling hypothesis explains the prevalence of complex life cycles in animals by stating that antagonistic selection leads to t
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Reposted by Jun Ishigohoka
FlyBase @flybase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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Reposted by Jun Ishigohoka
Molecular Biology and Evolution @molbioevol.bsky.social · 18/08/2026
McQueen, Yang & Wittkopp show that epistatic interactions between new mutations and as little as one nucleotide change impacting gene regulation can alter the distribution of mutational effects on gene expression. 🔗 doi.org/10.1093/molb... #societyjournal #evobio #molbio
doi.org
Epistatic impacts of cis- and trans-regulatory mutations on the distribution of mutational effects for gene expression in Saccharomyces cerevisiae
Abstract. Epistasis can influence evolution by causing the distribution of phenotypic effects for new mutations to vary among genotypes. Here, we investiga
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Reposted by Jun Ishigohoka
Lisandro Milocco @milocco.bsky.social · 17/08/2026
What can development contribute to predicting evolution? I argue it sets what evolution can access, and this depends on timescale since different parts of development evolve at different rates. Hence coarse-graining: keep only what matters 📣 New in @evojlinnsoc.bsky.social doi.org/10.1093/evol...
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Reposted by Jun Ishigohoka
Genetics Society of America @genetics-gsa.bsky.social · 13/08/2026
Happy birthday to Friedrich Miescher! In 1869, Miescher became the first scientist to isolate what he called “nuclein” from the nuclei of white blood cells—the substance we now know as #DNA. Read more in #GENETICS: buff.ly/0wReMtD
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Reposted by Jun Ishigohoka
Daohan "Rex" Jiang @rexjiang.bsky.social · 07/08/2026
I am organizing a symposium titled "How microevolutionary mechanisms produce macroevolutionary patterns" for the annual meeting of the Society for Evolutionary Studies, Japan this year. The conference will take place from Aug. 19-22 in #Nagoya. sesj2026.agr.nagoya-u.ac.jp/program_en.h...
sesj2026.agr.nagoya-u.ac.jp
Schedule & Program | The 28th Annual Meeting of the Society for Evolutionary Studies, Japan (Nagoya Meeting 2026)
This is the program page for the 28th Annual Meeting of the Society for Evolutionary Studies, Japan. Information on symposiums, oral presentations, poster sessions, and other program details will be p...
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Reposted by Jun Ishigohoka
Matthew Hahn @3rdreviewer.bsky.social · 31/07/2026
Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...
journals.plos.org
Levels of additive genetic variation vary substantially between species
Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...
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Jun Ishigohoka @junishigohoka.bsky.social · 30/07/2026
academic.oup.com/mbe/article/...
academic.oup.com
The life history of recessive deleterious alleles as seen through the eyes of a honey bee (Apis mellifera)
Abstract. Deleterious mutations arise continually in natural populations, yet their full life histories—from origin to elimination—are rarely observed dire
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Reposted by Jun Ishigohoka
Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n
doi.org
Differential epigenetic regulation underlies evolutionary transition of seasonal migration
Abstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolves
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Jun Ishigohoka @junishigohoka.bsky.social · 26/07/2026
www.nature.com/articles/s41...
nature.com
Theoretical morphospace reveals mixed optimisation of the avian wing planform for flight style - Nature Communications
Here, the authors examine bird wing planform shape and functional performance using theoretical morphospace and phylomorphospace. They find that, in a sample of 1138 extant bird taxa, planform shape i...
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Many thanks to all coauthors, especially @genmig.bsky.social 12/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
We are curious whether selection on seasonal traits generally acts on genetic variation in the slope of the reaction norm, instead of the intercept. 11/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Combining these results with the biogeographic history since the last ice age, we argue that blackcap populations diverged through range expansion during the last glacial retreat, with divergent selection acting on genetic variation in the slope of the reaction norm for migratory liability. 10/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Our previous population genomic study showed that multiple resident blackcap populations split simultaneously from ancestral migrants in parallel, and that over the same period the migrants themselves diverged into populations with different migratory distances. 9/n doi.org/10.1002/ece3...
doi.org
Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap
We investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulati...
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
We found that the amount of seasonal change in chromatin accessibility (i.e. the slope instead of the intercept), was reduced in multiple hypothalamic cell types in the resident blackcaps compared with ancestral migrants. 8/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
To answer this question, we ran a common garden experiment on blackcaps from ancestral migratory and derived resident populations, then performed scATAC-seq in the hypothalamus, treating the seasonal hypothalamic chromatin accessibility as a proxy for seasonal migratory liability. 7/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
In our paper, we asked what mode of change in the liability reaction norm underlies the evolution of the resident phenotype from ancestral migrants. Is it a reduced baseline liability (the intercept of the reaction norm)? A reduced seasonal change (the slope of the reaction norm)? Or both? 6/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Importantly, migrants express the migratory phenotype only during the migratory season. This can be accommodated by treating liability as a plastic trait with a seasonal reaction norm. In migrants, the baseline liability is below the threshold and exceeds it only during the migratory season. 5/n
doi.org
Properties of phenotypic plasticity in discrete threshold traits
Abstract. Forms of phenotypic plasticity in key traits, and forms of selection on and genetic variation in such plasticity, fundamentally underpin phenotyp
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Under the threshold model, different selective pressures on migratory liability are expected to drive divergence in migratory propensity between populations. One extreme is the evolution of resident populations from ancestral migratory populations. 4/n
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
Historically, within-species variation in migratory propensity has been modelled using the "threshold model" of quantitative genetics, in which animals express migratory phenotype when their liability — a latent variable shaped by both genotype and environment — exceeds a fixed threshold. 3/n
doi.org
The Genetics and Evolution of Avian Migration
Abstract. One of the characteristics of avian migration is its variability within and among species. Variation in migratory behavior, and in physiological
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
The Eurasian blackcap shows a suite of population-specific migratory phenotypes: long-, medium- and short-distance migrants, plus multiple resident populations. 2/n
doi.org
The evolutionary history and genomics of European blackcap migration
Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
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Jun Ishigohoka @junishigohoka.bsky.social · 24/07/2026
New paper out in Phil. Trans. B! We set out to understand how seasonal migration evolves by combining a common garden experiment and scATAC-seq of the hypothalamus in ancestral migratory and derived resident populations of the Eurasian blackcap. 1/n
doi.org
Differential epigenetic regulation underlies evolutionary transition of seasonal migration
Abstract. Seasonal migratory animals can evolve residency through adaptation. The threshold model of quantitative genetics predicts that residency evolves
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Reposted by Jun Ishigohoka
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 23/07/2026
Genotype-by-environment-by-environment (GxExE) interactions have the potential to shape adaptation in response to multiple stressors www.biorxiv.org/content/10.64898/20…
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Reposted by Jun Ishigohoka
Nature @nature.com · 22/07/2026
Researchers have discovered a contagious cancer in catfish – just the fourth example of tumour cells that spread naturally from one animal to another go.nature.com/4fsoLR3
go.nature.com
Rare contagious cancer discovered in wild catfish
Transmissible tumours have been found in only a few types of animal, but there might be many more out there.
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Reposted by Jun Ishigohoka
Cristian Gutierrez-Ibañez @gallinaciega.bsky.social · 22/07/2026
Neural correlates of seed-eating in songbirds royalsocietypublishing.org/rspb/article... Our new paper showing that songbirds that dehusk seeds with the beak and tongue have an enlarged trigeminal nucleus in the brainstem, particularly the part where the tongue is represented.
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Reposted by Jun Ishigohoka
Cauã Westmann @cauawest.bsky.social · 22/07/2026
Our latest paper on how transcription factor binding sites for global regulators can evolve in bacteria is now published in eLife! Mutation by mutation, we are uncovering the regulatory landscapes of bacteria. elifesciences.org/digests/1037...
elifesciences.org
Step by mutational step
New bacterial regulatory interactions can evolve more readily than previously appreciated, providing new insights into the evolution of gene regulation.
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Reposted by Jun Ishigohoka
Craig MacLean @craigmaclean.bsky.social · 27/06/2026
New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.
rdcu.be
Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
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Reposted by Jun Ishigohoka
Violeta Caballero-Lopez @viocablop.bsky.social · 09/07/2026
📢 happy to share our new paper in @molecology.bsky.social Common chiffchaff subspecies diverge in the same migration-related region as willow warblers (see thread): onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Common Chiffchaffs (<fi>Phylloscopus collybita</fi>) Diverge in a Genomic Region Associated With Migration Differences in Willow Warblers (<fi>Phylloscopus trochilus</fi>)
Despite technological advances in both tracking and sequencing technologies, finding the genetic mechanisms behind migratory traits remains a challenge. Recent studies have shown that migratory direc...
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Reposted by Jun Ishigohoka
ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 15/07/2026
#ERGAReads | 🐦‍⬛ 🦜 🪶 Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds academic.oup.com/gbe/article/... #genomes #birds #convergentevolution #birdgenomics @genomebiolevol.bsky.social @erichjarvis.bsky.social
academic.oup.com
Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds
Abstract. Vocal learning, the ability to imitate sounds, is a complex convergent trait crucial for spoken language and observed in a few independent lineag
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Reposted by Jun Ishigohoka
Earl K. Miller @earlkmiller.bsky.social · 15/07/2026
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience
news.mit.edu
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86
Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...
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Reposted by Jun Ishigohoka
Sergio Hidalgo Sotelo @sergiohidalgo.bsky.social · 15/07/2026
I am very happy to share that our article, "Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism," is now available in Science Advances. 🎊 (1/4) www.science.org/doi/10.1126/...
science.org
Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism
The circadian clock integrates photoperiodic and temperature cues by RNA splicing to promote seasonal plasticity.
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Reposted by Jun Ishigohoka
Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026
New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...
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Jun Ishigohoka @junishigohoka.bsky.social · 15/07/2026
www.science.org/doi/10.1126/...
science.org
CD4+ T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis
CD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies.
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