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Julien Béthune

@julienbethune.bsky.social
179 followers 271 following 42 posts

Professor @HAW Hamburg, interested in RNA & membrane biology, enzyme engineering & proteomics

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Reposted by Julien Béthune
Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 25/09/2026
What role do membrane contact sites play in bacterial pathogenesis and infection? To explore this question, 24 PIs from across Germany, representing two scientific communities - lipid biology and infection biology - came together at CSSB. More info:https://t1p.de/xe7u0 @carobarisch.bsky.social
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Monika Wolkers @monikawolkers.bsky.social · 10/09/2026
Now out in print. We studied the interactome of ZFP36L1 in human T cells We show how its interactome changes throughout T cell activation And whether or not interactions require the presence of RNA Great collaboration with @julienbethune.bsky.social www.life-science-alliance.org/content/9/11...
life-science-alliance.org
Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells
Effective T cell responses against pathogens require a rapid yet tightly controlled remodeling of the proteome, and RNA binding proteins (RBPs) are key in this process. For instance, the RBP ZFP36L1 p...
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Oded Rechavi @odedrechavi.bsky.social · 04/06/2026
I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.
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Timothy Snyder @timothysnyder.bsky.social · 24/05/2026
Last night Russia attacked seventy-seven places in Ukraine with more than six hundred drones and missiles. You can help protect Ukrainian life by donating here. u24.gov.ua/news/timothy...
u24.gov.ua
Timothy Snyder Joins Sky Defense to Help Protect Ukrainian Cities
The goal is $500,000, which will be used to procure interceptor drones and other air defense equipment.
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Reese Richardson @reeserichardson.bsky.social · 21/05/2026
@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...
Apparent manipulation in the antibody verification data in Thermo Fisher's online catalog
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Erik Sontheimer 🇺🇸💙🇺🇦 @eriksontheimer.bsky.social · 29/04/2026
Site-specific, multi-kilobase insertions and over-writes in mammalian cells, without DSBs, HDR, recombinases, integrases, transposases, or active cell cycling? Using fully or predominantly single-stranded DNA donors? 1/15
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Calin Plesa @calin.bsky.social · 03/03/2026
New lab preprint: if ML struggles with extrapolation, let's expand the diversity of training data with gene synth, DNA shuffling, and ML gen.... also lots of #FluorescentProteins #ProteinEngineering #MachineLearning #SyntheticBiology 1/n
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 19/02/2026
A new paper shows that less than 2 months of exposure to Twitter’s algorithmic feed significantly shifts people’s political views to the right. Moving from chronological feed to the algorithmic feed also increases engagement. This is one of the most concerning papers I’ve read in awhile.
The political effects of X's feed algorithm
https://doi.org/10.1038/s41586-026-10098-2
Received: 16 December 2024
Accepted: 4 January 2026
Published online: 18 February 2026
Open access
• Check for updates
Germain Gauthier,5, Roland Hodler?5, Philine Widmer35 & Ekaterina Zhuravskaya3,4,5 m
Feed algorithms are widely suspected to influence political attitudes. However, previous evidence from switching off the algorithm on Meta platforms found no political effects'. Here we present results from a 2023 field experiment on Elon Musk's platform X shedding light on this puzzle. We assigned active US-based users randomly to either an algorithmic or a chronological feed for 7 weeks, measuring political attitudes and online behaviour. Switching from a chronological to an algorithmic feed increased engagement and shifted political opinion towards more conservative positions, particularly regarding policy priorities, perceptions of criminal investigations into Donald Trump and views on the war in Ukraine. In contrast, switching from the algorithmic to the chronological feed had no comparable effects.
Neither switching the algorithm on nor switching it off significantly affected affective polarization or self-reported partisanship. To investigate the mechanism, we analysed users' feed content and behaviour. We found that the algorithm promotes conservative content and demotes posts by traditional media. Exposure to algorithmic content leads users to follow conservative political activist accounts, which they continue to follow even after switching off the algorithm, helping explain the asymmetry in effects. These results suggest that initial exposure to X's algorithm has persistent effects on users' current political attitudes and account-following behaviour, even in the absence of a detectable effect on partisanship.
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Julien Béthune @julienbethune.bsky.social · 06/02/2026
IOC as dumb as ever
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Constantinople lab @constantinoplelab.bsky.social · 30/01/2026
Our lab will be boycotting biotech vendors that have contracts with ICE (e.g., Fisher, Agilent), and telling them why. If you google “vendorname usa spending”, you can see purchases for specific depts including ICE on usaspending.gov. Please talk to your labs and email your vendors!
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Carlo "Realism, Gedankenfetzen und Rants" Masala @carlomasala1.bsky.social · 26/01/2026
Wenn ihr das Geld erübrigen könnt (man kann auch zusammenlegen). Jedes Kit hilft! Ukraine2Power hat ein Überlebenskit für 80€ (Gaskocher, Heizdecken, Hand/Fusswärmer, Thermoskanne, Powerbank) zusammengestellt. Konto: We Aid gGmbH IBAN: DE 52370205000001838801 Kennwort: Ukraine2Power Danke 🙏
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Oded Rechavi @odedrechavi.bsky.social · 26/01/2026
Like the genetic code, bitcoin, or national borders, our methods for evaluating science are a "frozen accident": things that were formed from historical circumstances rather than careful design, and that persist not because they are optimal, but because replacing them is extraordinarily difficult.
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Daniel Pomarède @pomarede.bsky.social · 21/01/2026
The sunglasses you didn't know you needed Pacific 01 S, by Henry Jullien www.instagram.com/henry_jullien/
French president Emmanuel Macron wearing blue sunglasses, photographed against a blue background.
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Deutsche Forschungsgemeinschaft @dfg.de · 16/01/2026
In den vergangenen Tagen wurde auf verschiedenen Social-Media-Plattformen über die Vorankündigung diskutiert, dass die DFG zukünftig unter bestimmten Rahmenbedingungen die Nutzung von KI in der Begutachtung ermöglichen wird. Mehr⏬
Insbesondere zu den beiden Prinzipien Vertraulichkeit und Verantwortung wurden viele Argumente ausgetauscht. Dies ist sehr verständlich, denn beide Prinzipien sind für die wissenschaftliche Integrität essenziell. In den kommenden Wochen werden die angekündigte Nutzungs- und Transparenzleitlinie sowie weitere Informationen veröffentlicht. Vor diesem Hintergrund wird die DFG auch Informationsveranstaltungen anbieten. Wir danken der Community für die engagierte Debatte. 

zur Information für die Wissenschaft Nr. 102 | 15. Dezember 2025
Künstliche Intelligenz in der Begutachtung
Hauptausschuss der DFG ermöglicht unter Rahmenbedingungen künftig die Nutzung von KI in der Begutachtung
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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 05/01/2026
Have you registered yet? Early bird registration and abstract submission are open until January 31. mosbacher-kolloquium.org
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UNITED24 @u24.gov.ua · 24/12/2025
A carol for peace. Together with the Embassies of Germany, the United Kingdom, and France, representatives of the Ministry of Culture, and Ukrainian artists from the National House of Music and Open Opera Ukraine, performed Shchedryk (Carol of the Bells) in the heart of Kyiv❤️
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Philip K. @herbilis.bsky.social · 12/12/2025
immaterielles Kulturerbe "Verspätung der Deutschen Bahn"
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Julien Béthune @julienbethune.bsky.social · 22/11/2025
Yesterday we celebrated the graduation of the first Erasmus Mundus cohort of our international master program EMMaH - Euro-Asian Master of Medical Technology and Healthcare Business in Lille. Congratulations to all our new graduates and good luck for your future endeavors!
Welcome address for the EMMaH graduate ceremony Introducing slide for the partner universities The degree documents on a tableThe first Erasmus Mundus graduates of the EMMaH masters with robes, hats and degrees
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Kai Koddenbrock @kaikodden.bsky.social · 15/10/2025
"Wer wird eingeladen? Wen sehen wir als „sichtbar“ und „erfolgreich“? Und wessen Leistungen übersehen wir systematisch, weil sie mehr Zeit brauchten, um dorthin zu kommen?"Tolle Reflexion @mariehuber.bsky.social zu Karriere und Kindern in der Wissenschaft seriousjourneys.substack.com/p/alleinerzi...
seriousjourneys.substack.com
Alleinerziehend in der Wissenschaft: Was Dauerstellen nicht lösen
Ein Kommentar, angeregt von "Ziel erkannt, Ziel verfehlt?" von Amrei Bahr und Kristin Eichhorn
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Oded Rechavi @odedrechavi.bsky.social · 15/10/2025
It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers.
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taz @taz.de · 14/10/2025
Die AfD Sachsen-Anhalt fragt gezielt nach Listen postkolonialer Seminare und Lehrstühle. Wie die Universitäten beginnen, sich gegen die Angriffe zu wappnen.
taz.de
AfD hetzt gegen Hochschulen: Angriff auf die Freiheit der Wissenschaft
Die AfD Sachsen-Anhalt fragt gezielt nach Listen postkolonialer Seminare und Lehrstühle. Wie die Universitäten beginnen, sich gegen die Angriffe zu wappnen.
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Patricia Skowronek @patiskowronek.bsky.social · 08/10/2025
In labs, hands-on expertise is often lost because it's not written down. We leverage multimodal AI agents to capture & share expertise by analyzing video and speech to generate protocols, detect errors, and guide researchers. #AI #TeamMassSpec 📄 Preprint: doi.org/10.1101/2025... 1/🧵
doi.org
Multimodal AI agents for capturing and sharing laboratory practice
We present a multimodal AI laboratory agent that captures and shares tacit experimental practice by linking written instructions with hands-on laboratory work through the analysis of video, speech, an...
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Victor Tatarskiy @greenrat.bsky.social · 02/10/2025
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky
On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.
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Julien Béthune @julienbethune.bsky.social · 18/09/2025
www.biorxiv.org/content/10.1... For anybody doing proximity-dependent biotinylation have a look at this reference preprint from the @gingraslab.bsky.social . Ten enzymes benchmarked in various conditions, it appears #ultraID is the enzyme of choice for combined specificity, speed and low background🧪
biorxiv.org
Benchmarking of proximity-dependent biotinylation enzymes across cellular compartments and time windows
Proximity-dependent biotinylation has become a powerful approach for mapping protein interactions and subcellular organization in living cells. Although a growing number of engineered biotin ligases h...
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Auschwitz Memorial @auschwitzmemorial.bsky.social · 12/09/2025
12 September 1924 | A Hungarian Jew, Tibor "Ted” Bolgar, was born in Sárospatak. In June 1944, he was deported to #Auschwitz from where he was taken to other camps. He was liberated during a death march from Muhldorf. Today he turns 101. Join us in wishing him a happy birthday.
Black and white portrait of a young man in a shirt, looking directly at the camera with a slight smile.
An elderly person with glasses and a cap smiling inside a busy bus.
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Ben Williamson @benpatrickwill.bsky.social · 07/09/2025
Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:
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Frank Vehafric @fvehafric.bsky.social · 03/09/2025
Well that's amazing.
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Julien Béthune @julienbethune.bsky.social · 02/09/2025
First time in the fair city of Béthune since 1991, glad to be back in the town that bears my name and recommended visit if visiting north of France!
Mr Béthune in front of the city hall of Béthune The city hall of Béthune View of Béthune’s belfry and church towerSome historic houses in Béthune
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Stephen Royle @steveroyle.bsky.social · 27/06/2025
This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport. The mechanistic basis of cargo selection during Golgi maturation Taylor, Zubkov, Ciazynska et al. doi.org/10.1101/2025...
doi.org
The mechanistic basis of cargo selection during Golgi maturation
The multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a cons...
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André Nadler @nadlerlab.bsky.social · 21/08/2025
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
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Joachim Goedhart @joachimgoedhart.bsky.social · 16/12/2024
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
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Julien Béthune @julienbethune.bsky.social · 31/07/2025
🧪 this one is a nice one for anybody interested in the early secretory pathway!
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Robert Arkowitz @robertarkowitz.bsky.social · 31/07/2025
www.nature.com/articles/d41...
nature.com
Scientific bedlam at the world’s weirdest and wildest research conference
Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.
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David Sancho @sancholab.bsky.social · 16/07/2025
💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky
nature.com
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
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JJ @jjodx.eurosky.social · 19/06/2025
Are bar plots without error bars or individual data really the future? While I agree on many things said here, I don't think that the chosen examples of bar plots are a good way forward
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Julien Béthune @julienbethune.bsky.social · 19/06/2025
The magician in Hamburg earlier this week
Carlos Santana playing the guitar
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Consortium for Top-Down Proteomics @proteoforms.bsky.social · 19/06/2025
Program now available for 3rd INTERNATIONAL TOP-DOWN PROTEOMICS SYMPOSIUM in Hamburg, Germany August 26-28 and DEADLINES approaching: >Early Registration ends - JUNE 30 >For Oral Abstract Submissions – JUNE 30 >For Poster Abstract Submissions – JULY 15 Get the Program here >> publ.cc/UFWQwg
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Yoav Gilad @ygilad.bsky.social · 07/06/2025
We developed CrossFilt, a read-level, cross-species filtering approach that avoids these errors without sacrificing usable data. It outperforms all existing strategies and exposes just how much signal in comparative genomics has been misread. doi.org/10.1101/2025...
doi.org
CrossFilt: A Cross-species Filtering Tool that Eliminates Alignment Bias in Comparative Genomics Studies
Comparative functional genomic studies are often affected by biased read mapping across species due to inter-species differences in genome structure, sequence composition, and annotation quality. We d...
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FC St. Pauli @fcstpauli.com · 26/05/2025
7. Oktober und Gaza-Krieg: Humanität ist unteilbar! #fcsp
blog.fcstpauli.com
7. Oktober und Gaza-Krieg: Humanität ist unteilbar!
In den vergangenen Monaten hat es in und rund um unseren Verein zahlreiche Debatten über den Nahost-Konflikt gegeben. Dazu möchte der FC St. Pauli einige grundlegende Gedanken teilen und einige falsch...
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Julien Béthune @julienbethune.bsky.social · 13/05/2025
Biotechnology and science communication at its best: Ad-hoc-Präsentation unserer HAW Hamburg Studierenden über ihr Forschungsprojekt vor Maryam Blumenthal, Senatorin für Wissenschaft, Forschung und Gleichstellung 💪🧪💪
HAW Hamburg Students show their poster to Hamburg’ senator for research
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Noémie Naguet de Saint Vulfran @nnaguet.bsky.social · 05/05/2025
D'où viennent les mythes ? Les versions changent avec le temps en suivant des lois darwiniennes, raison pour laquelle il est possible de remonter à leurs origines, en construisant des arbres phylogénétiques. Cela fait 10 ans que les chercheurs construisent de tels arbres. Comment font-ils ? 👇
media.tenor.com
a black background with flowers and the words `` once upon a time ''
ALT: a black background with flowers and the words `` once upon a time ''
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Sebastian S. Cocioba @atinygreencell.bsky.social · 02/05/2025
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚
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Ricardo Henriques @henriqueslab.bsky.social · 25/04/2025
🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors pubs.aip.org/aip/apr/arti...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 25/04/2025
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...
nature.com
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
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Julien Béthune @julienbethune.bsky.social · 20/04/2025
Happy Eastern!
High end chocolate bunny
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Julien Béthune @julienbethune.bsky.social · 15/04/2025
Hamburg, April 2025
Superreiche?
Superscheisse!
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