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Jim Mansfield

@jrmansfield.bsky.social
335 followers 351 following 138 posts

Personal account. Spatial biology and multiplex imaging. Scientist, sports fan, and amateur musician. An eclectic mix of science, politics, sports, and music content. #JEDIcouncil4mIFIHC

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Reposted by Jim Mansfield
Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 21/08/2026
"Structural inequalities in segregation, economic conditions, and educational access emerge as key pathways linking historical slavery to contemporary mortality disparities…"
pnas.org
Historical slavery predicts contemporary disparities in mortality between Black and White Americans | PNAS
We tested whether contemporary Black–White mortality disparities in the United States may be rooted in the historical legacy of slavery and perpetu...
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 22/08/2026
Oh God almighty, the horror show continues; you can see why RFK Jr and Bhattacharya want him These “treatments” are utterly barbaric
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Helen Kennedy @helenkennedy.com · 21/08/2026
The Trump administration fired the editor of Stars & Stripes. The military newspaper's publisher, who announced he would retire earlier this week, was also fired. The paper had revealed the deplorable conditions on the USS Lincoln, embarrassing Hegseth and Trump.
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Bill Stewart @billstewart.bsky.social · 19/08/2026
It's amazing how many people simultaneously believed that Covid was a nothingburger cold gone by Easter and you should patriotically get it over with so the bars can reopen, and also that Covid was Fauci's Chinese Bioweapons Lab Leak Designed To Kill Us All. I mean, pick one or the other.
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Eric Topol @erictopol.bsky.social · 18/08/2026
The dangers of RFK Jr's peptide push Example: "If you have a few precancerous cells lurking indolently in your prostate or breast, injecting a peptide that stimulates human growth hormone might supercharge them into a tumor." gift link wapo.st/4wycy3O
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Sanho Tree @sanho.bsky.social · 18/08/2026
“X’s algorithm learns what you hate and shows you more of it, according to a new study just published in the Proceedings of the National Academy of Sciences (PNAS)…It also showed that X serves more ragebait to people who say they are Democrats, although the exact reason for that is unclear.”
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Eric Topol @erictopol.bsky.social · 18/08/2026
Enough of the cure talk. Where are the cures for these diseases?
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International Society for Advancement of Cytometry @isacytometry.bsky.social · 13/08/2026
We're excited to begin the journey toward another unforgettable CYTO experience filled with groundbreaking science, global collaboration, and innovative discoveries. And to kick things off, we're thrilled to announce the CYTO 2027 Program Chairs! Raluca Niesner, PhD Sara De Biasi, PhD
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Don Moynihan @donmoyn.bsky.social · 06/08/2026
Is this just business as usual in politics? No. Approval rates of federal disaster aid requests were about the same regardless of the state and did not vary much with the party of the President. This graph powerfully conveys the scale of the partisan discrimination now.
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 13/08/2026
Ingest your own BS, DoJ:
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Eric Topol @erictopol.bsky.social · 12/08/2026
By the WSJ editorial board www.wsj.com/opinion/dona...
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Keri Martinowich @martinowk.bsky.social · 12/08/2026
With expansion of several stem cell based initiatives @lieberinstitute.bsky.social - we are hiring! We are looking for a Staff Scientist with expertise in hiPSCs and iPSC-derived neuronal models to join our Stem Cell Core, directed by @tsawada1.bsky.social recruiting.paylocity.com/recruiting/j...
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EMBL Events @events.embl.org · 11/08/2026
You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.
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Jim Mansfield @jrmansfield.bsky.social · 09/08/2026
First peer-reviewed paper combining Imaging Mass Cytometry with Xenium on the same FFPE section. Found EMT & checkpoint signatures invisible at the transcript level. Congrats @ankuroncofetal.bsky.social @standardbiotools.bsky.social et al! doi.org/10.1158/2767... #SpatialBiology #IMC
doi.org
An Integrated Spatial Multi-Omics Workflow for Sequential RNA and Protein Profiling in FFPE Tumor Tissue
Abstract. Understanding complex cellular niches, such as tertiary lymphoid structures (TLS), requires spatially resolved, multi-omic approaches that link transcriptional states and protein expression ...
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NJBIZ @njbiz.bsky.social · 31/07/2026
In case you missed it: Michael Johnson steps down as NJII president to lead Multiplex Bio, acquiring Standard BioTools' mass cytometry business in a deal valued up to $10 million.
NJII president departs to launch Multiplex Bio
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Greg Folkers @gregfolkers.bsky.social · 04/08/2026
Nature: Controversial White House plan to overhaul US science funding faces Senate opposition by Dan Garisto @nature.com @dangaristo.bsky.social go.nature.com/3TWoXRw
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Dan Froomkin/Press Watch/Heads Up News @froomkin.bsky.social · 31/07/2026
This is a completely insane interview in that the things they are discussing are so alarming that their heads should be exploding and yet they are calm. History will be unkind to those, like the NYT, who underreacted to Trump’s violation of the country. 1/2 www.nytimes.com/2026/07/31/o...
nytimes.com
Opinion | How Trump Has Changed, With Maggie Haberman
The New York Times correspondent says 70 percent of the president’s mind is dedicated to White House renovations.
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Eric Topol @erictopol.bsky.social · 30/07/2026
Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it gift link www.nytimes.com/interactive/...
nytimes.com
Inflammation Keeps Us Alive. It's Also Making Us Sick. (Gift Article)
The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.
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derek guy @dieworkwear.bsky.social · 29/07/2026
Despite all the accusations of crimes and cover-ups, the Trump admin has never actually prosecuted or jailed anyone. The supposed stolen 2020 election, Jan 6 deep state, Dr Fauci, etc. All of its is just theater for the base, revving them up. In the end, will undermine faith in gov and institutions.
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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 30/07/2026
Had a super lovely time on this podcast talking about bioimage analysis -the practice, the career, and the ~*~magic~*~ of it all. Check it out below!
bioinformaticscro.com
Beth Cimini - The Bioinformatics CRO Podcast
Beth Cimini, of the Cimini Lab at the Broad Institute, discusses her work at the intersection of microscopy, computational biology, and open source software.
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Peter Jacobs @pjacobs.bsky.social · 30/07/2026
Said this before, and will keep saying it: Prior to vaccine availability in the US, almost 1 in 5 people hospitalized during the pandemic DIED. For those admitted to an ICU it was more like 40-50%. The vaccines, and then the combination of vaccines and less lethal variants, changed everything.
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Jon B. Wolfsthal @jonatomic.bsky.social · 29/07/2026
History will praise Fauci as a leader and will bunch his accusers with McCarthy and J Edgar Hoover. They praise themselves at the cost of good men and women who know and care and seek to help our country. They have no decency, at long last.
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Olúfẹ́mi O. Táíwò @olufemiotaiwo.bsky.social · 29/07/2026
to keep functioning, a society must discourage baldfaced lying, especially by authorities
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Eleanor Courtemanche @ecourtem.bsky.social · 29/07/2026
This is why they’re going after Dr Fauci: he impeded grifters
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Science Magazine @science.org · 23/07/2026
A new special issue, with papers in Science and #ScienceAdvances, features single-cell and multiomic studies from the National Institutes of Health Common Fund's 4D Nucleome Program, which examines a fourth dimension of nuclear organization. Learn more: scim.ag/4wc4SF8
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 27/07/2026
"Many publicly traded companies are putting out announcements about their AI productivity gains when I know for a fact that the businesses have done nothing other than purchase Copilot licenses and declare victory."
ludic.mataroa.blog
AI Mania Is Eviscerating Global Decision-Making — Ludicity
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Greg Egan @gregegansf.bsky.social · 27/07/2026
While the Fields Medal celebrates the under-40s, the mathematician Joan Birman has, at the age of 99, solved a major open problem in representations of the Braid groups, a topic she has worked on for more than 60 years.
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Jenna Norton @jenna-m-norton.bsky.social · 24/07/2026
NIH is testing their ability to terminate “unaligned” grants, with at least one new termination documented. Disgustingly, they awarded this grant simply so they could add a termination clause. Then they terminated it. From @jocelynkaiser.bsky.social www.science.org/content/arti...
science.org
NIH is again terminating grants that the Trump administration dislikes
With cancellation of health disparities project, agency may be testing new way to legally kill politically sensitive grants
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Paul Bleicher @pbleic.bsky.social · 24/07/2026
Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
nytimes.com
FDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)
In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
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Mike Masnick @masnick.com · 25/07/2026
Wait. They all shake hands at the end? What are we even doing here? He's the US President suing you for $20 billion for reporting on the birthday card he sent his friend the pedophile in which he drew a naked girl & mused about secrets. And they all shake hands?
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 25/07/2026
This is their overt goal. They are not pretending otherwise.
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Aaron Sojourner @aaronsojourner.org · 25/07/2026
Admirable clarity @science.org
The Trump administration hates academic science funding, full stop. They hate where that money goes, and they hate who it goes to. They want to keep all that money for themselves, to hand out to favored cronies who can help them get elected and to steer yet more money and more power back into their hands.

That’s it. That’s the story
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Nikolai Slavov @slavov-n.bsky.social · 18/07/2026
Communicating research results is among the most important aspects of science; it can be tremendously rewarding and gratifying. Yet, it often falls short. This is an insightful & humorous take on giving a talk by @itaiyanai.bsky.social. 1/
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Ben Allen @evodynamics.bsky.social · 17/07/2026
Congrats we just made it impossible to come here for a PhD www.bostonglobe.com/2026/07/16/m...
bostonglobe.com
Trump administration limits student visas to four years, changing longstanding policy - The Boston Globe
The new rule, which also restricts the international students’ ability to transfer schools or change majors without approval in their first year, will go into effect in mid-September.
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Vicki Metzis @vmetzis.bsky.social · 17/07/2026
How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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Danielle Beckman @daniellebeckman.bsky.social · 17/07/2026
This is not AI. This is real microscopy! 🔬 An intact gut, rendered transparent and imaged in 3D using light-sheet microscopy! 🤓 Looking inside organs to investigate where pathogens, immune cells, or disease processes may persist. More at: www.nature.com/articles/s41... Happy #FluorescenceFriday!
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Albert Vilella, PhD. @albertvilella.bsky.social · 15/07/2026
Element Bio @elembio.bsky.social wins a court battle against @illumina in Germany, and what it means for the #NGS and #Multiomics fields moving forward open.substack.com/pub/albertvi...
open.substack.com
Element Bio succeeds in German court battle against Illumina over MiSeq and MiSeqDx instruments
And what it means for the NGS and Multiomics segment moving forward
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 15/07/2026
youtube.com
The Guns of Brixton (Remastered)
YouTube video by The Clash - Topic
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Rita Strack @ritastrack.bsky.social · 15/07/2026
At the biophotonics GRC, my brain is still processing the quantum microscopy introduced by Lihong Wang. He noted that his lab is hiring students and postdocs!
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Eric Topol @erictopol.bsky.social · 13/07/2026
The serious looming further threat to US science www.newyorker.com/magazine/202...
newyorker.com
An O.M.B. Plan to Defund Science—and Anything Trump Doesn’t Like
Under a new proposal, Administration officials could deny government grants to any group or project on the ground that it didn’t fit the President’s agenda.
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Alexandre Dumoulin @axonsalex.bsky.social · 22/11/2024
Happy #FluorescenceFriday ! Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo. #neuroscience #microscopy
Happy #FluorescenceFriday !
Let's celebrate with a colorful snapshot of the developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 13/07/2026
There are only a few hours left to comment on the proposed OMB rule that would eviscerate American science. This is the single best summary, and guidance for how to write a comment, that I have seen. PLEASE submit something, even if it is only 2 or 3 paragraphs.
elizabethginexi.substack.com
What We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB-2026-0034)
What OMB’s Proposed Federal Financial Assistance Rule Means in Practice
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Manuel Kleiner @manuelkleiner.bsky.social · 10/07/2026
The type and amount of bacterial DNA carried by virus-like particles in the gut microbiome is simply mind-boggling. Amazing work by PhD candidate Jessie Maier in my group and collaborators @duerkoplab.bsky.social and Ben Callahan www.biorxiv.org/content/10.6...
biorxiv.org
Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome
Horizontal gene transfer (HGT) is a driving force in microbial evolution that allows community members to rapidly evolve to cope with environmental stressors and competition. Despite the importance of...
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Joel Lüthi @joelluethi.bsky.social · 30/06/2026
Working with OME-Zarrs in @napari.org ? Check out the newest release of napari-ome-zarr-navigator to make your life easier & allow more interactive ways to write back to OME-Zarrs. Follow the thread for more (1/5 🧵)
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Mark Carney @mark-carney.bsky.social · 30/06/2026
It’s time to unlock Canada’s full potential as an energy superpower.
Screenshot of an article from CTV News. The headline reads: Canada has 'once in a lifetime opportunity' to become an energy superpower: head of IEA.
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Max Kozlov @maxkozlov.bsky.social · 27/06/2026
NIH grants have been under political scrutiny since early 2025. But what does the screening process actually look like? What is being flagged? I spent a month digging into leaked docs and emails. We've published the 235-word list that are being flagged by an internal AI tool. And so much more. 🧵
nature.com
Inside the new political screening that’s stalling NIH grants
Mandatory reviews by top health officials and checks for 235 disfavoured terms have left hundreds of vetted grant applications in administrative limbo.
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Karin Pfisterer @pfistererkarin.bsky.social · 22/06/2026
🚨We are recruiting a Postdoc🚨 We are seeking a highly motivated Postdoctoral Researcher for our newly funded Horizon Europe Mission Cancer Melanoma Project! 🎯Apply, if you are interested in extracellular matrix-cancer cell interactions, tissue mechanics, advanced fluorescence imaging in 2D and 3D!
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markkhurana.bsky.social @markkhurana.bsky.social · 21/06/2026
🚨 Where do new SARS-CoV-2 variants come from? Our new paper in @natcomms.nature.com suggests they stem from persistent infections. We found that immunosuppressed patients face a 5x higher risk of prolonged infection, with the virus mutating at an accelerated rate. www.nature.com/articles/s41...
nature.com
Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infections - Nature Communications
Using Denmark’s genomic surveillance linked to health registries, the authors identify immunosuppression as a key risk factor for persistent SARS-CoV-2 infections and show these infections accumulate ...
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Elizabeth McKenna @elizsmckenna.bsky.social · 24/06/2026
It's another KRAS day at Cancer Discovery @aacrjournals.bsky.social! Three papers now online about mutant KRAS alleles, rewiring that occurs after allele-specific KRAS inhibition, and potential combination approaches 👇
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