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Jeff Jones, PhD

@jrjones.bsky.social
265 followers 365 following 32 posts

Molecular biologist focused on aging

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Jeff Jones, PhD @jrjones.bsky.social · 09/02/2026
I’m honored to be featured in an MBI Researcher Highlight from the University of Florida. In the Jones Lab, we study how age-related metabolic changes in neurons influence DNA integrity and contribute to cognitive decline. I'm Grateful to the McKnight Brain Institute! Read more: bit.ly/4amqx3U
bit.ly
MBI Researcher Highlight: Dr. Jeff Jones » McKnight Brain Institute » University of Florida
Dr. Jeffrey Jones' research aims to illuminate age-related metabolic changes in neurons in normal cognitive aging and dementia that result in changes in DNA, to find new treatments.
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Jeff Jones, PhD @jrjones.bsky.social · 02/02/2026
"Tomorrow's illiterate will not be the man who can't read; he will be the man who has not learned how to learn." Herbert Gerjuoy
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Asaf Levy @asaflevylab.bsky.social · 26/10/2025
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
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Eric Topol @erictopol.bsky.social · 09/10/2025
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...
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Elinne Becket, PhD @bielleogy.bsky.social · 29/09/2025
I'm still mad someone decided to call them H2A, H2B, H3, H4.
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Jeff Jones, PhD @jrjones.bsky.social · 28/07/2025
Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊 #Neuro #Aging #Alzheimers #UF ufresearch.bsky.social‬
https://ufresearch.bsky.social‬
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ahellab.bsky.social @ahellab.bsky.social · 10/07/2025
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...
nature.com
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
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Eric Topol @erictopol.bsky.social · 25/05/2025
Front page, NYT today Nothing has been proven to reverse Alzheimer’s disease, including this false claim gift link www.nytimes.com/2025/05/21/w...
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The Conversation U.S. @us.theconversation.com · 18/05/2025
The NSF helped fund the tech in your phone, the models that forecast deadly storms and 268 Nobel prize-winners. The Trump Administration has proposed cutting its budget by 55% – and 1400+ grants are already terminated.
buff.ly
Unprecedented cuts to the National Science Foundation endanger research that improves economic growth, national security and your life
The Trump administration has terminated hundreds of federal grants that support engineering, biology, geology, computer science, STEM education and much more.
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Jeff Jones, PhD @jrjones.bsky.social · 13/05/2025
Great paper out today by my friend and colleague James Tucker! I'm hopeful that some of these scaffolds have therapeutic value. www.sciencedirect.com/science/arti...
sciencedirect.com
Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity
The human protein kinase CK2 has long been of interest as a target in oncology, but new evidence is emerging of its role in central nervous system (CN…
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Eric Topol @erictopol.bsky.social · 04/05/2025
Good summary of this important study linking blood pressure control and reduced dementia www.nature.com/articles/s41...
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Astronomy 🔭 @astronomy.bsky.social · 18/04/2025
Albert Einstein died on this day, April 18, 1955. It is incredible to hear Albert Einstein explain his famous formula, E=mc².
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Oregon 🕎🎲 @oregonthedm.bsky.social · 09/04/2025
Biggest commitment to a 3 second joke I've ever seen
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Jeff Jones, PhD @jrjones.bsky.social · 01/04/2025
My annual post for today: In the era of rampant misinformation, April Fools just doesn't seem appropriate or funny
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Jeff Jones, PhD @jrjones.bsky.social · 31/03/2025
Conda users will get this Solving Environment: \
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Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Society for Neuroscience @sfn.org · 18/03/2025
Success often requires community support. Discuss practical approaches to creating more accessible & inclusive research settings in this webinar w/ @umarchatterjee.bsky.social, Kimberly Fiock, PhD, Billie Goolsby, BA, @brittgratreak.bsky.social, & @dwwilliamslab.bsky.social. #NeuroSky
SfN Neuronline Professional Development Webinar - Disabled in Neuroscience: Promoting Equitable and Accessible Research for All. March 19, noon-1:30 p.m. EDT. Colorful scientific image background.
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Eric Topol @erictopol.bsky.social · 13/03/2025
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/...
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Jeff Jones, PhD @jrjones.bsky.social · 11/03/2025
He would see the entire world burn just to be the king of ashes
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Science Magazine @science.org · 07/03/2025
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
scim.ag
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
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Technology Connections @techconnectify.bsky.social · 03/03/2025
A really clarifying question that I think should be asked of basically every politician out there is "what do you imagine power to be and why do you want it?"
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Omar Wasow @owasow.bsky.social · 02/03/2025
Between 2010 and 2024, CDC estimates that flu resulted in an estimated 9.3 million to 41 million illnesses, 120,000 to 710,000 hospitalizations and 6,300 to 52,000 deaths annually. That’s *with* widespread use of the flu vaccine. www.cdc.gov/flu-burden/p...
Image shows a pyramid with three bands. At bottom CDC estimates that flu has resulted in 9.3 million to 41 million illnesses. The middle band shows an estimate of 120,000 to 710,000 hospitalizations and the peak shows an estimated 6,300 to 52,000 deaths annually between 2010 and 2024.
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Tristan Snell @tristansnell.bsky.social · 01/03/2025
This is Winston Churchill visiting the White House during World War II. Funny how he isn’t wearing a suit either. Almost like he was a wartime leader defending his country from being slaughtered and wiped out by an authoritarian aggressor.
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BK. Titanji @boghuma.bsky.social · 26/02/2025
I commend every parent who is choosing to do the right thing by vaccinating their child as the measles outbreak spreads. There's no shame in changing your mind on a stance you were wrong about. Especially when it concerns protecting children from disease. www.nbcnews.com/health/healt...
nbcnews.com
As Texas measles outbreak grows, parents are choosing to vaccinate kids
At least 124 people, mostly babies, children and teens, have been infected. Eighteen people have been hospitalized.
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Jack Iwashyna @iwashyna.bsky.social · 20/02/2025
Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading www.linkedin.com/posts/nathan...
February 18, 2024
TO:
Dr. Matthew Memoli, Acting Director, NIH
CC:
John Burklow, Chief of Staff, NIH
Julie Berko, Director, OHR, NIH
FROM:
Nathaniel James Brought, Director, ES, NIH
SUBJECT: Resignation
Dear Dr. Memoli,
On July 3, 2001, I stepped off a bus on Marine Corps Recruit Training Depot Perris Island. Scared out of my mind, I stood on a pair of freshly painted yellow footprints, raised my right hand, and recited the oath of enlistment:
I, Nathaniel James Brought, do solemnly swear that I will support and defend the Constitution of the United States against all enemies, foreign and domestic; that I will bear true faith and allegiance to the same; and that I will obey the orders of the President of the United States and the orders of the officers appointed over me, according to regulations and the Uniform Code of Military Justice. So help me God.
For the last 23 years, 7 months, and 15 days, I like to believe I have faithfully carried out the duties of each office to which I've been appointed in my military and civilian service to this nation. That Service has taken me from the Marine Corps to 3 different federal departments, spanned 3 continents, included service in one war zone, and has included:
• For the Marine Corps and the National Security Agency, I worked on intelligence operations at the highest classification levels using bleeding edge intelligence tools to ensure America's special operators put boots-to-asses on America's enemies overseas (including commendations crediting my work for the kill or capture of dozens of terrorists), ensuring America's policy makers were able to track the movement of dangerous dualnuclear technology across international borders, and monitored the flow of terrorist financing across the international banking system.
• Utilized information from all-source intelligence to ensure the continued security of America's homeland from international and domestic threats.
• Worked with some of the finest lawyers in the world to ensure America's security operations were effective, while upholding the rights of all those who interacted with them.
• Ensuring that America's rural communities had access to programs like rural development loans, farm aid, and that America's children wouldn't be hungry as they sat in their classrooms and tried to learn.
• Most recently, and frankly most dear to my heart, working with each of you here at the National Institutes of Health to advance the future of science and medicine. Not for Americans. Not for any one group of people. But for ALL of humanity.
I am unbelievably proud to be able to say that there are Americans who are alive, and terrorists who are not, because of the work I've done to serve this nation. I am proud to say that my service to this country has allowed me to ensure that my children have never faced the struggles of poverty that I grew up with. That service didn't begin because of some great altruistic impulse or drive. I didn't grow up saying "I want to do the great work that needs to be done to weave the fabric of America and ensure her people are not only safe, but healthy." Frankly, that service began because I was poor, and I was inspired. I grew up as a free lunch kid who lived in project housing. It was my fellow Americans who made sure I wasn't hungry in class and that I had enough food to excel academically the way I did. It was Americans who had more than we did that made sure I had good schools to attend where I could learn things that expanded my mind.
As I approached the end of high school, I dreamed of going to college and figuring out how to make a living that would allow me to do more tha…to go to college. I knew my grades weren't good enough to compete for scholarships with kids who were as smart as me but also had private tutors and didn't have to work after class to be able to drive their brand-new cars to our school each day. So, I gave up. I nearly failed my senior year of high school with an attendance failure, even though I only needed two classes to graduate. I didn't see the point. What was the point of learning calculus? So it would be that much harder when my dream of being a brain surgeon died not because I was incapable, but because I didn't have the means to make it come true? I resigned myself to being one of the working poor. I resigned myself to needing a spinal fusion before I was 50, like my father, because he literally broke his back trying to make his dreams come true. The example of my father didn't inspire me at that time. It reminded me of the futility of trying to escape the rung of the social ladder I had been born onto. No matter how smart or "gifted and talented" I may have been, I saw no path that led me to a place where I could realize my potential. So, instead I accepted that it would be wasted.
Ultimately, the reason I find myself here today, rather than in the place I saw as my only end, is because of another young man who committed to serving his country. Shamefully, I do not remember his name, but there was a young corporal from the United States Marine Corps who had been assigned as a recruiter in Reading, Pennsylvania at that time. This man spoke to me about my plans for my future during lunch one day at school. I told him I planned to do what my father had done. Work hard jobs until my body broke down, maybe start a struggling business, and try to do what I could to stay above the poverty line and off welfare. I told him I hoped to be successful enough that my kids never had to watch me use food stamps at the grocery store. It had been hard to watch my mom go through that. How sad is that? I was a smart young 18-…
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Jeff Jones, PhD @jrjones.bsky.social · 05/02/2025
This is not the increased brain plasticity I had hoped for... edition.cnn.com/2025/02/03/h...
edition.cnn.com
Human brain samples contain an entire spoon’s worth of nanoplastics, study says | CNN
Human brains today contain 50% more plastic than in 2016, a new study found. Brain of people diagnosed with dementia had the most.
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Jeff Jones, PhD @jrjones.bsky.social · 05/02/2025
TO-DO lists will grow if left unchecked
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onion person @junlper.beer · 01/02/2025
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Jeff Jones, PhD @jrjones.bsky.social · 31/01/2025
Claims made without evidence can be dismissed without justification
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beetle moses @beetlemoses.bsky.social · 26/01/2025
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Dave Levitan @davelevitan.bsky.social · 25/01/2025
There are currently 67,102 studies registered at clinicaltrials.gov that are (well, were, probably, until this week) actively recruiting participants, and 20,690 studies that are active but not recruiting right now. This is SO many people we're talking about.
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Jeff Jones, PhD @jrjones.bsky.social · 21/01/2025
"Look back over the past, with its changing empires that rose and fell, and you can foresee the future, too." - Marcus Aurelius
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Bluesky @bsky.app · 03/12/2024
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
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Jose Maldonado, PhD @josemald.bsky.social · 04/12/2024
Lightsheet microscopy is unparalleled in its ability to resolve whole circuits in the mouse brain. Michelle Bedebaugh let me image one of her Rabies MC3R Cre samples with the 15X objective on my smartSPIM and we are very happy with the results. 🧪
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Mark Sumner 🌒 @devilstower.bsky.social · 29/11/2024
Six decades later, Star Trek may still be the only franchise based on the ideas that diversity is strength, justice is the measure of civilization, bounty is to be shared, peace is worth the price, and all these things can be achieved. We need more shows that look ahead and find goodness.
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The Washington Post @washingtonpost.com · 25/11/2024
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
washingtonpost.com
Inside your body, aging unfolds at remarkably different rates
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
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Roland Weisleder @rweisleder.de · 18/11/2024
Spending hours with ChatGPT can save you minutes of reading the documentation.
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Tricia Dearborn @triciadearborn.bsky.social · 18/11/2024
There is a special circle in hell for publishers who do not make the gutter margins big enough
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Lord Jeffrey of Nottingham #FBPE 🇬🇧 🇪🇺 🇬🇱 @onemoregoodman.bsky.social · 16/11/2024
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Dave Levitan @davelevitan.bsky.social · 12/11/2024
RFK Jr wants to gut NIH, which is fun because it’s the primary mechanism to fund biomedical research and because it is underfunded *80 percent* or more of researchers applying for the most common type of grant, known as an R01, don’t get funded.
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Jeff Jones, PhD @jrjones.bsky.social · 03/11/2023
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Jeff Jones, PhD @jrjones.bsky.social · 10/10/2023
That feeling when you find a typo in a manuscript you've read 10^10 times, but only after hitting submit 🙃
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