Modern biology is powered by the organization of biological information, a framework pioneered in 1965 by Margaret Dayhoff's Atlas of Protein Sequence and Structure. Databases descended from this comm...

This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

YouTube video by Chaitanya K. Joshi

The p-Tau217 Biomarker for Prediction and Prevention

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

Grant terminations halt research on improving vaccinations and preventing future pandemics

Department of Health and Human Services Secretary Robert F. Kennedy Jr. paused a $240 million contract to create a new coronavirus vaccine.

Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

Advances in machine learning have transformed structural biology, enabling swift and accurate prediction of protein structure from sequence. However, challenges persist in capturing sidechain packing,...

A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patie...

The findings suggest that AI contributes to the early detection of clinically relevant breast cancer and reduces screen-reading workload without increasing false positives.