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Jeremy Kay

@jnklab.bsky.social
1.6K followers 885 following 32 posts

Neuroscientist, retina nerd at Duke. Dept of Neurobiology & Duke Eye Center. Studying nervous system development, cell-cell recognition, and vision.

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Reposted by Jeremy Kay
Bob Johnston @bobbyjeyeguy.bsky.social · 25/08/2026
Happy to share our review by Allie Reed from my lab together with Karina Chaudhari and Alex Kolodkin discussing the conservation of retinal direction-selective circuits across vertebrates! www.sciencedirect.com/science/arti...
sciencedirect.com
Conservation of retinal direction-selective circuits across vertebrate species
Retinal circuits extract visual features such as color, contrast, and motion. Direction-selective (DS) circuits provide a well-studied model for under…
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Kristen Kwan @blockintheback.bsky.social · 14/08/2026
Celebrating the 2026 GRC on Visual System Development: a great meeting with exciting science and fantastic colleagues! Thanks to @jnklab.bsky.social and @flyeyelab.bsky.social for all of their work! Looking forward to planning the next one with @latorrelab.bsky.social and @macdonaldlab.bsky.social!
Some past and present Chairs and Vice Chairs of the GRC on Visual System Development (L-R): Jeremy Kay, Seth Blackshaw, Valerie Wallace, Ryan MacDonald, Nadean Brown, Bob Johnston, Kristen Kwan, Anna LaTorre, and Justin KumarAforementioned folks not being so serious
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Matt Smear @mattsmear.bsky.social · 25/03/2026
Visualizing and Sonifying NeuroData (ViSoND) github.com/Smear-Lab/Vi... is a strategy for observing multiple data streams in video and sound www.biorxiv.org/content/10.6... e.g., watch an animal move while you listen to their physiological signals (or vice versa)
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 22/01/2026
Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death www.biorxiv.org/content/10.64898/20…
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John Pearson @jmxpearson.bsky.social · 13/01/2026
My department, Duke Neurobiology, is searching for a new chair. Ad below. Come work with me, @jmgrohneuro.bsky.social @ennatsew.bsky.social @jorggrandl.bsky.social @jnklab.bsky.social @sbilbo.bsky.social @neurocircuits.bsky.social and many other amazing folks! @dukemedschool.bsky.social
nature.com
Department Chair, Duke Neurobiology - Duke University, Durham job with Duke University - School of Medicine | 12852576
The Duke University School of Medicine (SOM) seeks a distinguished neuroscientist to serve as the next Chair of the Department of Neurobiology.
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Michel Cayouette @michelcayouette.bsky.social · 29/10/2025
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
sciencedirect.com
Retinal glia regulate development of the circadian photoentrainment circuit
Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to th…
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Grace Lindsay @neurograce.bsky.social · 16/06/2025
I wrote a quick-start guide for people to replicate this across the country. It was, in our experience, a very effective way to get real action in a short amount of time. People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
docs.google.com
Postcard Drives for Science Instructions
Postcard Drive Instructions The main goals for this outreach are: A.) Get the public to (continue to) trust in and care about federally-funded science. B.) Get individuals to contact their Senators...
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Jeremy Kay @jnklab.bsky.social · 23/05/2025
Congrats!!
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Jeremy Berg @jeremymberg.bsky.social · 07/05/2025
I have previously posted about the slow issuance of NIH award in fiscal year 2025 compared to fiscal year 2024. jeremymberg.github.io/jeremyberg.g... These data were across all of the institutes and centers at NIH. The results can be examined for each institute and center. 1/n
jeremymberg.github.io
NIH_since_1_20_25
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Jeremy Kay @jnklab.bsky.social · 08/04/2025
Check out our new preprint! Microglia in different layers of the developing retina express distinct gene profiles - implications for how microglia influence development not just in the retina but throughout the CNS.
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Stand Up for Science! @standupforscience.net · 20/02/2025
☀️📣 Looking for a STATE LEAD and VOLUNTEERS to help us #standupforscience2025 in North Carolina! Know someone interested? Fill out this form: airtable.com/app4h5wUssMG... #scienceforall #sciencenotsilence
Image of north carolina with text looking for north carolina volunteers
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jp flores (he/him) @jpflores.rbind.io · 19/02/2025
Let's just say it gets bigger everyday... @standupforscifr.bsky.social We're doing this for the next generation of scientists. To uphold the integrity of science, protect its accessibility, and ensure its benefits serve all people. Join us. @standupforscience.bsky.social
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Scott Thompson, PhD @sthom003.bsky.social · 18/12/2024
The Senate Committee on Health, Education, Labor, and Pensions, led by Senator Bill Cassidy (R-LA) - a gastroenterologist with an MD from LSU, just released a report entitled NIH IN THE 21st CENTURY: ENSURING TRANSPARENCY AND AMERICAN BIOMEDICAL LEADERSHIP. Since he is the ranking Republican, 1/n
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Markus Meister @mameister4.bsky.social · 14/12/2024
Horace Barlow, by all accounts, was thinking about 30 years ahead of his time. Here is a transcript of the opening keynote I gave at a symposium honoring Horace's scientific legacy: markusmeister.com/2024/12/14/h....
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Shane Liddelow @liddelowsa.bsky.social · 11/12/2024
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)
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Marla Feller @mfeller.bsky.social · 10/12/2024
New preprint! A wonderful collaboration of our @FellerMarla lab with Matthew Po, and @shekharlab. Here, we dive into the impact of spontaneous activity on the transcriptome of retinal ganglion cells (RGCs), the sole output neurons of the retina. www.biorxiv.org/content/10.1...
biorxiv.org
Transcriptomic changes in retinal ganglion cell types associated with the disruption of cholinergic retinal waves
In the early stages of retinal development, a form of correlated activity known as retinal waves causes periodic depolarizations of immature retinal ganglion cells (RGCs). Retinal waves are crucial fo...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 07/12/2024
RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR www.biorxiv.org/content/10.1101/202…
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Bita Moghaddam @bita137.bsky.social · 02/12/2024
“While even the agency’s defenders acknowledge that the NIH needs modernization, the radical reforms proposed would be difficult, if not impossible, without YEARS of legal wrangling and significant support from Congress” Exactly! So let’s work on allies in congress www.nytimes.com/2024/12/01/h...
nytimes.com
Long a ‘Crown Jewel’ of Government, N.I.H. Is Now a Target
The agency long benefited from broad bipartisan support. But Republican criticism has intensified, and new choices for top health posts hope to upend the organization.
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John Pearson @jmxpearson.bsky.social · 30/11/2024
Parable time: After the incredible successes of quantum electrodynamics in the late 1940s, particle physics went through what is now considered a pretty fallow period in the the 1950s and 60s. Many interesting ideas from that time that survived (selectively summarized much later in Coleman) 1/n
google.com
Aspects of Symmetry
For almost two decades, Sidney Coleman has been giving review lectures on frontier topics in theoretical high-energy physics at the International School of Subnuclear Physics held each year at Erice, ...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 30/11/2024
While our bodies seem static, our cells are constantly changing shape or on the move during tissue homeostasis or wound repair & even more dramatically during embryonic development, during events like gastrulation. Defining how cellular machines mediate these events is a key task for our field 1/n
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Dr. Brittany J. Carr @drbjcarr.bsky.social · 27/11/2024
This is one of my all-time favorite figures. It shows the size comparison between a retinal bipolar cell and a cortical pyramidal cell in a mouse. Scale bars are great and all but sometimes the sizes just don't compute. Masland. (2012). The Neuronal Organization of the Retina. 🧪 #neuroskyence
An image showing a labelled red and green colored retina on the left hand side with a white circled bipolar cell. On the right hand side, the circled bipolar cell is shown to scale in comparison with a pyramidal neuron from the brain. It is about 1/10th the size, and barely visible.
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Gord Fishell @gordfishell.bsky.social · 24/11/2024
Excited to publish a broad set of enhancers to target interneuron types in the brain, along with a broad set of collaborators. Part of the BI armamentarium. Together this will help revolutionize the targeting of brain circuits.https://www.biorxiv.org/content/10.1101/2024.07.17.603924v2
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Tom Baden @neurofishh.bsky.social · 20/11/2024
New @bioRxiv #preprint with @chiarafornetto.bsky.social and @teuler.bsky.social : www.biorxiv.org/content/10.1...
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Jeremy Kay @jnklab.bsky.social · 20/11/2024
🙋‍♂️
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2024
There are lots of us missing, but so many joining so quickly Please do share, and comment below to be added go.bsky.app/5f2V6L6 (microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)
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Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024
go.bsky.app/Eaua5Jk my starter for neuroimmunology
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/11/2024
go.bsky.app/SxcKi5z
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David Solecki @so-lets-kilab70.bsky.social · 16/11/2024
Neural development community coming together like Voltron with Sergiu’s Starter Pack!
media.tenor.com
a gif of a robot with the words make gifs at gifsoup.com at the bottom
ALT: a gif of a robot with the words make gifs at gifsoup.com at the bottom
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Melina A. Agosto @agostolab.bsky.social · 14/11/2024
The retina provides pretty pictures even when antibodies misbehave. I'm calling this one "bipolars in a starry sky".
Confocal microscope image of mouse retina labeled with antibodies for PKCalpha (red), TRPM1 (yellow), and 4.1B (cyan).
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Andrew Hardaway @andrewhardaway.bsky.social · 12/11/2024
"However, since the specific aims are abstracted for internal management and public reporting, including figures can interfere with application processing. Please advise your colleagues and other investigators not to include figures in the Specific Aims attachment of an NIH grant application."
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Jeremy Kay @jnklab.bsky.social · 27/08/2024
Our paper on retinal mosaic patterning came out in today’s issue of Cell Reports. See below for a thread I wrote last fall and check out the full paper here: www.cell.com/cell-reports... Congrats to co-authors Chris Kozlowski and Sarah Hadyniak!
cell.com
Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories
Evenly spaced “mosaics” of retinal neurons were discovered a century ago, but how mosaics form remains unknown. Here, Kozlowski et al. show that developing mouse starburst amacrine cells use MEGF10, a...
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Christian Puller @christianpuller.bsky.social · 17/12/2023
Once again, retinal neurons challenge textbook knowledge about wiring patterns and functional properties ❤️ 🧪 www.nature.com/articles/s41...
nature.com
A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interaction...
In the retina, visual information is segregated into ON (light increment) and OFF (light decrement) streams. Here, the authors identify a sign-inverting amacrine cell with an inhibitory ON center – ...
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Max Heiman @heiman.bsky.social · 22/11/2023
very nice! possibly relevant, we showed making more copies of a neuron is sufficient to create tiling by homotypic repulsion (heimanlab.com/content/2016...) -- I wonder what you minimally would need to express in another cell type to get it to be treated as part of the mosaic by starburst amacrines?
heimanlab.com
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Jeremy Kay @jnklab.bsky.social · 23/11/2023
We did show that misexpressing Megf10 indiscriminately will cause starbursts to avoid the misexpressing cells (see here: pubmed.ncbi.nlm.nih.gov/22407321/) but this isn’t quite the same thing.
pubmed.ncbi.nlm.nih.gov
MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons - Pu...
In many parts of the nervous system, neuronal somata display orderly spatial arrangements. In the retina, neurons of numerous individual subtypes form regular arrays called mosaics: they are less like...
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Jeremy Kay @jnklab.bsky.social · 23/11/2023
Yes of course I remember this super cool paper from your lab! We always wanted to test if misexpressing Megf10 in another cell type would suffice to incorporate those neurons into the starburst mosaic. But we never found the ideal way to do the experiment.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
There’s way more in the paper – for example, an unexpected difference between ON and OFF starburst cells. We hope you'll check it out on Biorxiv for all the details. www.biorxiv.org/content/10.1...
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
All in all, we think we’ve made some real headway in answering the longstanding question of how retinal neurons repel each other to establish mosaics. Congrats to Chris Kozlowski, who did the vast majority of work for this study, and co-author Sarah Hadyniak!
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
These anatomical observations suggest that the mechanism we describe for starburst neurons could also be involved in patterning the mosaics of other cell types, and that the mechanism may occur in primate retina as well as mouse.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
Also, browsing museum.eyewire.org one can find many intriguing examples of mouse retinal ganglion cell types that may be patterned similarly. Note in this image how each cell body is positioned at the edge of its neighbor's dendrite territory.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
Intriguingly, there are other retinal cell types that show homotypic dendrite-soma exclusion. For example, Dacey & Brace (1992) showed, in primate retina, that parasol retinal ganglion cells are positioned at the edges of their neighbors’ dendritic arbor territories.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
We conclude that newborn starburst neurons make space for themselves in the developing mosaic by contacting neighboring starburst cell bodies using their dendrites (see image for illustration). And that this is the primary mechanism for starburst mosaic patterning.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
That’s exactly what we found: Megf10 mutant starbursts could no longer exclude homotypic neighbors from their dendrite territories.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
Based on this past work, we know that starbursts can’t repel each other anymore in Megf10 mutant mice. So, if dendrite-soma exclusion is really the mechanism for starburst repulsion, it should be messed up in Megf10 mutants.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
But how do we know that dendrite-soma exclusion is involved in mosaic patterning? Back when I was a postdoc, we studied a cell surface molecule, MEGF10, that is required for starburst exclusion zone formation. Without MEGF10, starbursts are randomly positioned.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
To show that the apparent exclusion of somata from dendritic territories was real and did not arise by chance, first author Chris Kozlowski generated thousands of control dendrite + soma images and counted them by hand. It was an amazing amount of work.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
It almost looked like the baby starburst neurons were reaching out to grab their neighbors and hold them at arm’s length.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
When we labeled dendrites of baby starburst neurons, we saw a striking coordination between the dendritic arbor and neighboring starburst cell bodies. Somata were lined up around the edge of the dendritic arbor, suggesting they were physically excluded from the arbor territory.
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
We needed to build new tools for looking at fine starburst anatomy in very young animals, because mosaics are established early – shortly after the neurons are born. In other words: what do baby starbursts look like? i.imgur.com/LHssG6u.gif [please click the GIF links...you won't regret it 😁]
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Jeremy Kay @jnklab.bsky.social · 21/11/2023
To address this problem we focused on mouse starburst amacrine cells, which have long been a model for studying how mosaics form.
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