Jörg Grandl @jorggrandl.bsky.social · 04/03/2026Beautiful new work on the force-gated ion channel Piezo2. 050
Jörg Grandl @jorggrandl.bsky.social · 18/02/2026"Here, we measure the sensitivity of the force-gated ion channel Piezo2 and demonstrate that it is modulated by alternative splicing." New preprint: www.biorxiv.org/content/10.6... 0124
Reposted by Jörg GrandlArdem Patapoutian @ardemp.bskyverified.social · 11/02/2026We are looking for a new member of the Patapoutian lab: recruiting2.ultipro.com/SCR1003TSRI/...recruiting2.ultipro.com 0149
Reposted by Jörg GrandlJohn Pearson @jmxpearson.bsky.social · 13/01/2026My department, Duke Neurobiology, is searching for a new chair. Ad below. Come work with me, @jmgrohneuro.bsky.social @ennatsew.bsky.social @jorggrandl.bsky.social @jnklab.bsky.social @sbilbo.bsky.social @neurocircuits.bsky.social and many other amazing folks! @dukemedschool.bsky.socialnature.comDepartment Chair, Duke Neurobiology - Duke University, Durham job with Duke University - School of Medicine | 12852576The Duke University School of Medicine (SOM) seeks a distinguished neuroscientist to serve as the next Chair of the Department of Neurobiology. 02425
Reposted by Jörg GrandlCordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti... 1/5sciencedirect.comStructures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal bladePIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t… 2138
Reposted by Jörg GrandlJustin Taraska @taraska.bsky.social · 22/12/2025My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053... 16044
Reposted by Jörg GrandlPlessLab @plesslab.bsky.social · 26/11/2025To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026: network.febs.org/posts/new-jo... Further details to come soon. Please share and repost. 01312
Reposted by Jörg GrandlArdem Patapoutian @ardemp.bskyverified.social · 18/09/2025New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...biorxiv.orgPIEZO channels link mechanical forces to uterine contractions in parturitionMechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a... 113142
Reposted by Jörg GrandlArdem Patapoutian @ardemp.bskyverified.social · 19/06/2025I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...kpbs.orgNobel laureate on how Trump's cuts are hurting scienceNeuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche... 2185123
Reposted by Jörg GrandlJie Xu @jie-xu.bsky.social · 09/06/2025Excited to share our latest story in Nature. We developed a high-throughput cellular stretch system to look for genes regulating membrane rupture under tension, and found an amazing small protein called NINJ1 that weakens the membrane for rupture! H/T to Zozo, my 10-y.o. for her artist's impression😃 2186
Reposted by Jörg GrandlSociety of General Physiologists @sgpweb.bsky.social · 05/05/2025Join us for the next SGP EpIC Seminar on Tuesday, 5 May, at 12:00 pm Eastern featuring a talk by Amanda Lewis, "Piezo1 ion channels are capable of conformational signaling." As ever, registration is free and all are welcome. sgp-epic-seminars.com 074
Reposted by Jörg GrandlArdem Patapoutian @ardemp.bskyverified.social · 09/04/2025Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...cnn.comNobel laureate: I owe America my success. Today, its scientific future is in danger | CNNDr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted... 15893488
Jörg Grandl @jorggrandl.bsky.social · 31/03/2025📣 📣 📣 Optically Guided Tension Clamp 📣 📣 📣 Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel! #IonChannel #Biophysics Read more: www.cell.com/biophysj/ful... 1205
Reposted by Jörg GrandlArdem Patapoutian @ardemp.bskyverified.social · 01/03/2025The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!media.tenor.coma cat is laying on top of the number 25ALT: a cat is laying on top of the number 25 101687
Reposted by Jörg GrandlPliotas Group @pliotasgroup.bsky.social · 10/02/2025In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...cell.comThe mechanosensitive channel YbiO has a conductance equivalent to the largest gated-poreLane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows... 1165
Reposted by Jörg GrandlDan Minor @electrosomeucsf.bsky.social · 07/02/2025Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels). portlandpress.com/biochemsoctr...portlandpress.comElectrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)–chaperone interactionsIon channels are multicomponent complexes (termed here as“electrosomes”) that conduct the bioelectrical signals required for life. It has been appreciated for decades that assembly is critical for pro... 032
Jörg Grandl @jorggrandl.bsky.social · 03/02/2025Our lab will be presenting 1 talk at 3 posters at the upcoming Biophysical Society Annual Meeting. If you are attending we would love to connect with you and show our work: 1) A CLOSED-LOOP SYSTEM FOR MILLISECOND READOUT AND CONTROL OF MEMBRANE TENSION. Poster B284. Monday, Feb 17 1:45 PM 1100
Jörg Grandl @jorggrandl.bsky.social · 21/01/2025To catch up, I recently had the opportunity to give a seminar at Johns Hopkins - Neuroscience. How much fun to meet my former Scripps Chair Uli Mueller and @ardemp.bskyverified.social postdoc colleague Zhaozhu Qiu, and make new friends Alex Kolodkin, Edward Twomey, and Xinzhong Dong. 090
Jörg Grandl @jorggrandl.bsky.social · 20/01/2025Excited to join Bluesky today! As an ion channel biophysicist, Professor at Duke Neurobiology, and Director of Graduate Studies I will be sharing my insights. Plus the occasional post of my private life. Please help me connect to my community by sharing this post. 87318
Jörg Grandl @jorggrandl.bsky.social · 20/01/2025Follow the work of the Grandl Lab: sites.duke.edu/grandllab/ 091
