Abstract. Nicotinic acid adenine dinucleotide phosphate (NAADP+) and related NAD(P)+ analogues are important tools for calcium signaling, redox biology, an

COLLEGE STATION, TX — Sources across the Varma laboratory at Texas A&M University confirmed Monday that research technician Marcus Cole, 28, who can accurately pipette an entire 384-well plate while…

“Everyone will be affected, not just scientists. Every community in the country.“

Despite increasing interest, there remain limited treatments for chronic pain, with opioids continuing to be one of the top prescribed medications. Marine natural products present a wealth of untapped potential for new treatments for chronic pain. In this study, we investigated the analgesic effects of the sea sponge ligand barettin in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Barettin exhibited efficacious antihyperalgesic activity in male mice with no efficacy shown in females. Through the use of a PRESTO-Tango assay, we found that barettin acts as an inverse agonist at the 5HT2A receptor while also presenting no activity at the μ-opioid receptor. Head twitch experiments confirmed no hallucinogenic activity, suggesting that barettin may be a promising nonopioid, nonhallucinogenic, marine-derived therapeutic agent for the treatment of chronic pain.

Use Your Power for Purpose We are seeking a creative, highly motivated chemist with experience in biocatalysis to join Chemical Research and Development (CRD) in Groton, Connecticut. The successful ca...

In an ideal world, this week’s resignation of Food and Drug Administration Commissioner Marty Makary would signal the end of a troubling period at the agency — one where the job of overseeing a sizabl...

Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enli...

A Bring Me The News reporter was near the scene, and recorded multiple gunshots.

Lipid-binding domains, originally isolated from natural proteins, are useful tools essential for analyzing membrane lipids in cells, and their applications are varied. Yet, there is no general strateg...

Mission: SURF is designed to inspire undergraduate students to pursue careers in STEM (science, technology, engineering, and mathematics) through a unique research experience that supports the NIST mi...

Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...