The authors develop SPIN-Seq, a method that directly links the sequence of individual DNA molecules to their functional behavior, revealing how DNA sequence impacts protein-DNA interactions and the ki...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

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Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.

A new work from the Klose lab published in the journal Molecular Cell

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The major cellular protein phosphatases are widely recognized as transcriptional repressors. However, Wang et al. identify the PP1 phosphatase as a global transcriptional activator that activates paus...

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...