iiinova — where your digital self keeps evolving

Reposted by @neilblackledge.bsky.social

Alan Au @au-ho-yu.bsky.social · 11/12/2025

Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...

biorxiv.org

SET1/MLL complexes control transcription independently of H3K4me3

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

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Reposted by @neilblackledge.bsky.social

Emilia Dimitrova @edimitrova.bsky.social · 12/12/2024

We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!

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Reposted by @neilblackledge.bsky.social

Tim Behrens @behrenstimb.bsky.social · 30/11/2024

We don’t think the impact factor is a good thing. But this is not the fight we want right now. We are trying something amazing and it’s working. We don’t want authors or other journals to fear trying it. Clarivate know they have this control and are using it to squash innovation. It is bullying.

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neilblackledge.bsky.social @neilblackledge.bsky.social · 26/11/2024

Fantastic to see the latest story from the Klose lab out in Molecular Cell today! Thoroughly enjoyed being part of a team effort spearheaded by @jesskelley.bsky.social and @edimitrova.bsky.social! A project that briefly dragged us away from CpG islands before leading us back to the 5’ end of genes!

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