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Memory routinely transforms continuous experience into discrete episodes that support flexible retrieval. We propose that these structured representations are established via rapid neural reactivation...

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In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...

Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Inhibitory interneuron diversity is a central feature of cortical circuits. The IN-CODE consortium seeks to combine large-scale recordings of interneuron types with machine-learning tools to identify ...

The soaring cost and limited supply of computer memory is slowing some projects — and spurring creative approaches.

A trumpet-shaped, single-celled organism seems able to predict one thing will follow another, hinting that such associative learning emerged long before multicellular nervous systems

Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Monday, December 15, 2025 - Paris Brain Institute (Auditorium)

Golbabaei et al. explore how the contributions of projection-defined prelimbic cortex “sub-engrams” to contextual fear memory recall change with time. Sub-engrams projecting to the basal amygdala and lateral entorhinal cortex support recent memory recall, whereas sub-engrams projecting to the nucleus reuniens and nucleus accumbens are additionally recruited at remote delays.

With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.

A central component of wayfinding is the ability to maintain a consistent representation of one's facing direction (FD) when moving about the world. In rodents, head direction cells are believed to su...

Sensory inputs are progressively transformed into internal representations of the environment along the cortical hierarchy. How does the behavioral relevance of these inputs affect this encoding? Usin...

Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell

Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel me...

The real fun of being a neuroscientist, and maybe the key to asking and answering new questions, is to think big and take intellectual risks.

In this Perspective, Barabási, Ferreira Castro and Engert challenge the notion that learning and plasticity primarily drive the assembly of neural circuits. They present a tripartite framework for how...