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Changes in nuclear architecture during cell state transitions remain poorly understood. Here, the authors use O-SNAP, a framework to analyze SMLM images of chromatin, to reveal chromatin remodelling i...

TRPV5 ion channels play pivotal roles in epithelial physiology. Here, the authors describe that the common compound menthol acts as a pore blocker on these channels and provide a functional and struct...

Researchers are capturing images of the biology inside our cells using cryogenic electron microscopy to inform how we understand and treat disease.

Lysosomes are vital for cellular health and linked to many diseases. Here, authors use cryo-ET to image intact lysosomes and resolve lysosomal protein structures, providing a platform to advance the s...

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...

The authors use cryo-electron microscopy to reveal two structural states of Ca2+-activated gelsolin bound to the actin filament, illuminating the mechanisms of filament severing and barbed end capping...

Using cryo-electron microscopy, the structures of mammalian fatty acid synthase reveal how the acyl carrier protein dynamically shuttles intermediates between selected active sites.

Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...

YouTube video by Institute of Structural Biology UPENN