Microglia clear intraneuronal α-synuclein aggregates.

Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in ...

Researchers at the Francis Crick Institute, King’s College London and Complutense University of Madrid have shown that γδ T cells use adaptive immune receptors to drive rapid, innate-like responses to...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration *Speaker: Hao Hu (Washington University in St. Louis) *Moderator: Jerry Lin (Massachusetts General…

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

The serotonin system modulates nearly all neural circuits across development and adulthood and is a major pharmacological target for mood and anxie...

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent, metabolically trained state in sensory neurons that amplifies later neuroimmune responses to allergens and enables cross-sensitization to antigenically distinct allergens.

We now offer: ✅ Live streaming on Zoom and YouTube ✅ Live Q&A through Zoom (during live sessions) ✅ Asynchronous Q&A via YouTube comments (after live sessions, contingent to speaker availability) ✅...

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data sug...

The people who work in AI are not gurus and most of their predictions have been wrong. Working in the industry makes them less reliable commentators, not more

Dai et al. identify stress-responsive neuropeptide Y receptor Y1-expressing neurons in the hypothalamic paraventricular nucleus that engage the dorsal vagal complex to suppress feeding and delay gastric emptying. Inhibiting this pathway alleviates these stress-induced responses, revealing a hypothalamic-brainstem circuit coordinating feeding and gastric function during acute stress.