iiinova — where your digital self keeps evolving

Reposted by Luke Yates

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 17/04/2026

'Huge' congratulations to Dr Luke Yates, on being awarded a highly competitive Academy of Medical Sciences' Springboard programme — for research investigating how cells coordinate the process of DNA repair, using advanced molecular imaging and genetic tools @acmedsci.bsky.social

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Reposted by Luke Yates

Uli Rass @u-rass.bsky.social · 11/04/2026

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

Nature Communications banner with title of latest paper from the Yates, Oliver, and Rass groups at the Genome Damage and Stability Centre, University of Sussex: "Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32".

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Reposted by Luke Yates

NealeLab @labneale.bsky.social · 17/02/2026

Now live on Find-A-PhD-dot-com: Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.findaphd.com/phds/project...

findaphd.com

How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex on FindAPhD.com

PhD Project - How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex, listed on FindAPhD.com

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Reposted by Luke Yates

Bertolin Lab @bertolinlab.bsky.social · 18/02/2026

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

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Reposted by Luke Yates

Uli Rass @u-rass.bsky.social · 03/09/2025

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

nature.com

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

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Reposted by Luke Yates

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 29/08/2025

#NEW_PAPER The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

rdcu.be

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

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Reposted by Luke Yates

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 03/09/2025

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

doi.org

DNA2 enables growth by restricting recombination-restarted replication - Nature

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Luke Yates @layates.bsky.social · 06/08/2025

Absolute pleasure to be invited back on the @agentsoftech.bsky.social podcast to join Stephen Horn and Laila Rizvi and talk with #Nobel winner John Jumper about #AlphaFold and research at Google DeepMind. We also touch on needing experimentalists, and what he & AI will tackle next in biology

youtu.be

Exclusive Interview with Nobel Prize Winner John Jumper: AI's Next Frontier After AlphaFold

YouTube video by Agents of Tech

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Reposted by Luke Yates

keithcaldecott.bsky.social @keithcaldecott.bsky.social · 10/02/2025

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

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Luke Yates @layates.bsky.social · 11/02/2025

I have a funded PhD position in my lab in @gdsc-sussex.bsky.social (UK fees only). This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.

sussex.ac.uk

Life Sciences PhD Genome Stability - Molecular basis for DNA damage checkpoint termination : University of Sussex

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Reposted by Luke Yates

Alessandro Costa @costalaboratory.bsky.social · 11/12/2024

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

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Reposted by Luke Yates

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 06/12/2024

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

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Reposted by Luke Yates

Di Jiang @dijiang319.bsky.social · 05/12/2024

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social www.science.org/doi/10.1126/...

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Luke Yates @layates.bsky.social · 24/11/2024

The Equal Dose podcast by @websedgetv.bsky.social covered a topic very close to my heart - organ donation. And it was wonderful to share my story and very humbling to hear about Billy Moon’s legacy. Episode available here: youtu.be/9UAruhx2vk0?...

youtu.be

Celebrating 70 Years of Organ Transplants: Inspiring Stories of Legacy, Innovation, and Hope

YouTube video by WebsEdgeMedicine

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Luke Yates @layates.bsky.social · 15/11/2024

It was a pleasure to be invited on the ‘Agents of Tech’ podcast from @websedgetv.bsky.social to talk about how AlphaFold3 is transforming structural biology and biomedical research. Link to the episode below: youtu.be/ohKGM6A9vhQ

youtu.be

Building Blocks of Life, AlphaFold and AI Drug Development

YouTube video by WebsEdge

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