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Hoy Lipid Metabolism Lab

@hoylipidlab.bsky.social
883 followers 513 following 29 posts

Located the Charles Perkins Centre at the University of Sydney with research interests in type 2 diabetes, cancer metabolism, and obesity led by A/Prof Andrew Hoy

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Hoy Lipid Metabolism Lab @hoylipidlab.bsky.social · 24/02/2026
1/ Updated preprint (v2) out on bioRxiv! A wonderful team effort with @nancyts.bsky.social, Lake-Ee Quek and others. “Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer” Link: www.biorxiv.org/content/10.1...
biorxiv.org
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Mike Clark @michaelbclark.bsky.social · 26/11/2025
Australian #NHMRC Ideas grants are out. 8.1% success rate. Lowest since the scheme began. Congrats to the successful few, as it looks like less than 200 were funded. 🧪
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htw @heniek-htw.bsky.social · 01/05/2025
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis www.cell.com/molecular-ce...
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The EMBO Journal @embojournal.org · 17/11/2025
Measuring mitochondrial membrane potential @marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells www.embopress.org/doi/full/10....
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Carlo Barnaba 🇮🇹🇲🇽 @barnabalab.bsky.social · 29/10/2025
As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.
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James Olzmann @olzmannlab.bsky.social · 29/10/2025
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...
nature.com
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
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Mike Lange @mikelangelipid.bsky.social · 29/10/2025
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD
nature.com
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
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Molecular Systems Biology @molsystbiol.org · 03/07/2025
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
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Pieter Dorrestein @pieterdorrestein.bsky.social · 12/06/2025
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...
cell.com
Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...
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Hoy Lipid Metabolism Lab @hoylipidlab.bsky.social · 06/06/2025
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10.... We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
embopress.org
Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology
imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...
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Cellular Bioenergetics Laboratory @cellbioenerglab.bsky.social · 03/04/2025
Our group leader Prof Nigel Turner was interviewed for the Guardian earlier this week, discussing the hype and hope for NAD+ boosters as anti-ageing therapeutics. Read what he (and our collaborator A/Prof Lindsay Wu) had to say about it here: www.theguardian.com/australia-ne... 🧪
theguardian.com
NAD boosters: Kendall Jenner and Hailey Bieber are into them, but do they actually stop ageing? | Antiviral
Despite social media hype, there is little evidence that the therapies, marketed as pills, shots and IV infusions, have any effects on ageing
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ARC Tracker @arc-tracker.bsky.social · 25/03/2025
A Future Made in Australia … as long as no new knowledge is needed.
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ARC Tracker @arc-tracker.bsky.social · 20/03/2025
ARC has “paused” future rounds of grant schemes pending outcomes of its NCGP Policy Review. All schemes previously scheduled to open before 1 July this year will go ahead. But next year’s Laureates, Industry Fellowships & Discovery Indigenous won’t. See table👇 & www.arc.gov.au/funding-rese...
Black text on white background. Screenshot from ARC’s Grants Calendar webpage showing which schemes will go ahead next year (upper bullet points), and which will be “paused” pending the outcomes of the review of the National Competitive Grants Program (lower bullet points). Source: https://www.arc.gov.au/funding-research/ARC_grants-calendar
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Jason Cantor @jasonrcantor.bsky.social · 12/03/2025
happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...
cell.com
Seeing the world through the eyes of cultured cells
The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and adv...
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Maureen Barr @barrlab.bsky.social · 09/12/2024
When I try to explain how things are actually getting worse, people look at me like I'm crazy.This piece is spot on. #SIStem (senior #womeninSTEM)
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 05/12/2024
Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD events.abcam.com/event/cancer...
events.abcam.com
Home - Cancer and Metabolism
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Jason Cantor @jasonrcantor.bsky.social · 03/12/2024
a fitting first post to mark the beautiful PhD thesis defense this afternoon from our lab’s very first student! Kim’s courage to join a brand-new lab and her ensuing grit, enthusiasm, and creativity were exceptional! extremely proud of all she has achieved, stay tuned for some of her cool findings!
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Cosimo Commisso @cosimocommisso.bsky.social · 04/12/2024
I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities. www.nature.com/articles/s41...
nature.com
Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications
Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of mac...
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Phillip White @phillipjwhitephd.bsky.social · 15/11/2024
Registration is open for #METPHYS2025! www.sablesys.com/metphys2025-...
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Nick van Gastel @nickvangastel.bsky.social · 29/11/2024
We are hiring! There is still time to apply for an open postdoc position in stem cell metabolomics (mass spec experience required) in our lab, and we’ll soon open applications for a PhD student interested in studying metabolic crosstalk in the bone marrow (but feel free to already send me your CV)!
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Hoy Lipid Metabolism Lab @hoylipidlab.bsky.social · 29/11/2024
So good - @voodooglowskulls.bsky.social and Hey Smith in Sydney!
Hey Smith band on stageVoodoo Glow Skulls on stage
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ARC Tracker @arc-tracker.bsky.social · 29/11/2024
We've seen this movie before, Minister @jasonclaremp.bsky.social, in Japan. Please help us take a different path!
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ARC Tracker @arc-tracker.bsky.social · 29/11/2024
We’ve had nearly 3 years of review, review, review. We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done. This was true 3 years ago. Still true now. By @drjr.bsky.social
nature.com
Falling enrolments and funding cuts force Australian universities to take stock
The Australian Universities Accord offers a roadmap for reform, but there are major challenges ahead.
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Nuria Lopez-Bigas @nlbigas.bsky.social · 27/11/2024
Only a subset of patients respond to immunotherapy Why? Which ones? We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response. www.nature.com/articles/s41...
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Glen O'Hara @gsoh31.bsky.social · 26/11/2024
You can't save your university by cutting. That's an illusion. You can only weaken it further. See: the logic of Mr George Osborne, 2010-c.2013. Every redundancy programme in fact takes you closer to the edge. How can there still be people out there who don't realise this?
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Prof Gina Ravenscroft🇿🇦🇦🇺 @ginaravenscroft.bsky.social · 26/11/2024
If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs
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Andrew Burgess @drandrewburgess.bsky.social · 26/11/2024
Huge day in Australian Research with grant outcomes for both #ARC Discovery Projects and #NHMRC Ideas released. Congratulations to all those successful, and sincere apologies to the >85-90% who missed out. It's a brutal, brutal system with so many great grants and research missing out.
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Brendan Manning @bdmanning.bsky.social · 21/11/2024
Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
academicpositions.harvard.edu
Assistant Professor, Department of Molecular Metabolism
The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...
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Andrew Mendiola @andrewmendiola.bsky.social · 20/11/2024
I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.
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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 20/11/2024
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism? Then come join me & @juanquintana.bsky.social at @lydiabeckeriii.bsky.social as a research assistant Email to arrange an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Assistant in Tissue Immunology:Oxford Road
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Hoy Lipid Metabolism Lab @hoylipidlab.bsky.social · 20/11/2024
First post on here and it's one I always love to post - celebrating the final presentation of our amazing hons Natalie. She did a brilliant job and a great way to finish the year. Always rewarding.
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Itai Yanai @itaiyanai.bsky.social · 18/11/2024
Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."
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Ana Luisa Correia @alpcorreia.bsky.social · 17/11/2024
If you want to work at the interface of #cancer #dormancy #immunity in beautiful #Lisbon reach out to me. We have positions fully funded by #LaCaixa Join our amazing blue sky at Champalimaud Foundation ☀️
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