Insomnia is the most prevalent sleep complaint, occurring as a primary or comorbid condition, increasing the public healthcare burden. Prior reviews e…

Huang et al. show that prolonged exhalation increases risky decisions by enhancing reward sensitivity and cardiac parasympathetic activity. Individuals with greater parasympathetic upregulation exhibi...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 diabetes and atherosclerotic cardiovascular disease. This trajectory emphasises the urgent need to address this growing health crisis. Cardiometabolic diseases can have detrimental effects on bone health, leading to fractures, morbidity and mortality, and reduced quality of life.1 Despite these known relationships, bone health is often underestimated and overlooked in this context.

A rare variant of a gene called TP53 means Tracy Hutchinson has an extreme risk of developing cancer anywhere in her body, causing endless anxiety and requiring regular whole-body MRIs and other screening

Nature Metabolism, Published online: 27 May 2026; doi:10.1038/s42255-026-01535-7This study reveals that glycogen metabolism is crucial for the sensory activation of POMC neurons, which is necessary for proper feeding behaviour and metabolic health in mice.

Psychiatric disorders frequently co-occur with endocrine, nutritional, and metabolic disorders, complicating diagnosis, treatment, and prognosis. To d…

Insomnia is the most prevalent sleep complaint, occurring as a primary or comorbid condition, increasing the public healthcare burden. Prior reviews e…

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

To examine associations between ambient temperature and hospital admissions for mental health disorders among children (aged <=12), adolescents (aged …

Developmental biology; Chronobiology

In this Perspective, Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets.

Skin aging is a complex biological process driven by oxidative stress, chronic inflammation, and the disruption of extracellular matrix homeostasis. C…