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David Hofer

@hofer.bsky.social
336 followers 95 following 301 posts

I work on software for tracking genome sequences, edits and variants. Cat dad. Boston, MA

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Reposted by David Hofer
depths of wikipedia @depthsofwikipedia.bsky.social · 02/10/2026
The Phantom of Heilbronn, also referred to as the Woman Without a Face, was a presumed female serial killer whose existence was inferred from DNA evidence found at 40 crime scenes across Austria, France and Germany from 1993 to 2009.

In March 2009, investigators concluded that the supposed serial killer did not exist, and the DNA belonged to a woman who worked at a factory that made the cotton swabs used for collecting DNA samples
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Sarah Andersen @sarahseeandersen.bsky.social · 26/08/2026
The image is of a four panel comic.
The title above the first two panels reads, "Dog Toys".
The first panel shows Sarah, the protagonist, holding a bone shaped dog toy. She says, "Look!"
The second panel shows a dog wagging its tail. There is a speech bubble leading back to Sarah saying "It squeaks!"
The title above the last two panels reads, "Cat Toys".
In panel three we see Sarah again. She says "Come, child."
Panel four shows a cat raising its paws in glee. We see Sarah's hands holding cat nip. We see a speech bubble leading back to Sarah saying "It is time to do drugs".
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David Hofer @hofer.bsky.social · 27/09/2026
Was at the world cycling championship women’s elite race in Montreal today. Demi Vollering won; I got a picture of her and the top three finishers on the last lap. One thing they don’t show on TV is the sweep car
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Keifer @dannyvegito.bsky.social · 13/01/2026
[guy who can’t fully remember that Gramsci quote] it’s Monster Time
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David Hofer @hofer.bsky.social · 07/09/2026
Toledo is enjoying a nap
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David Hofer @hofer.bsky.social · 06/09/2026
Turkeys (the bird) are named in most languages after the place they are believed to have come from. In England they were imported from the Ottoman Empire. In Turkey, they are called “Indias”. In India, they are called “Perus”.
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David Hofer @hofer.bsky.social · 31/08/2026
Went hiking in the Adirondacks this weekend, then hung out by a river
Me in front of the summit of Haystack mountainMy feet on the sand by a river
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David Hofer @hofer.bsky.social · 24/08/2026
My solar + electric system just crossed over to being a net exporter for the year to date. It’ll probably go back to being a net importer in November or December, but I’m enjoying it for now
My solar electric system production/import/export numbers for the year
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Ramin Nasibov @nasibov.me · 12/08/2026
If you missed the solar eclipse, this is what it looked like:
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David Hofer @hofer.bsky.social · 02/08/2026
Was in New Bedford today, they have a huge awesome sculpture of a rooster made from discarded materials and trash
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scare-cadus (is this anything) 🎃 @birdapp.rip · 29/07/2026
A scene from The Odyssey where Penelope stands before the suitors, but Tim Robinson has been added in. It’s a reference to I Think You Should Leave. Penelope says “Ronnie, I feel like you’re just here for the zip line” and Tim Robinson says “what?”
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Brendel @brendelbored.bsky.social · 19/07/2026
Vanquished by the baby you washed is some Athena bullshit
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Adam Serwer @adamserwer.bsky.social · 15/07/2026
Messi goes super saiyan in the last 20 of every match and every opposing coach is like, what if he didn’t and we could just defend a narrow lead until the whistle
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The Life of Sharks @thelifeofsharks.com · 04/07/2026
Saw this ad for a goat on Facebook. It’s perhaps the greatest advert I’ve ever read. It’s just superb.
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David Hofer @hofer.bsky.social · 06/07/2026
Just read this morning there’s an effort to get rideshare drivers in Massachusetts to use EVs because they drive far more miles on average than anyone else, and I like how pragmatic my state is, overall
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Mrs Frog @musettedutour.bsky.social · 06/07/2026
Stage 2 Tarragone to Barcelone - After you, youngster #letourdepoupees #couchpeloton #sbscycling #TDF2026
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Mrs Frog @musettedutour.bsky.social · 05/07/2026
Stage 1 Barcelone to Barcelone - Stocking up for a hot TTT #letourdepoupees #couchpeloton #sbscycling #TDF2026
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TW @twesq.bsky.social · 02/07/2026
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Commercial Solar Guy @commercialsolarguy.com · 29/06/2026
“Comparing 1 acre of growing corn for ethanol, to 1 acre of solar panels to charge EVs”
Bar chart comparing annual vehicle miles per acre for corn versus Solar with the Solar being about 70 times greater
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Marie Le Conte @youngvulgarian.marieleconte.com · 27/06/2026
absolute height of comedy is when they cut to the goal and you see how many kid keepers they've got
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Buttercup Festival @buttercupfestival.bsky.social · 23/06/2026
The bell: Buttercup Festival 3-386
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Jane Coaston @janecoaston.bsky.social · 22/06/2026
Relatable.
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Mr. Joshua @pantspants.bsky.social · 05/06/2026
The New PJs (1/4)
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David Hofer @hofer.bsky.social · 03/06/2026
Toledo is enjoying the weather today on the back porch
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Emily Mullin @emilymullin.bsky.social · 28/05/2026
A network of research centers that was well-positioned to respond to the current Ebola outbreak in the Democratic Republic of Congo had its funding canceled last year by the Trump administration. My latest for @wired.com: www.wired.com/story/us-res...
wired.com
These Researchers Would Be in Africa Fighting Ebola—but Trump Cut Their Funding
The Centers for Research in Emerging Infectious Diseases were launched during the Covid-19 pandemic. The group lost its funding under Trump in part due to conspiracy theories.
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Alex Elizabeth Byrne McMillan @undeniablyalex.bsky.social · 23/05/2026
YOU’RE LISTENING TO SISYPHUS FM, THE HOME OF NON-STOP ROCK
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beetle moses @beetlemoses.bsky.social · 19/05/2026
Three panel comic. Panel 1: two dudes sitting in the car, driving late in the day. The friend in the passenger seat asks the other, “so, whats the move tonight?” Panel 2: a third friend in the backseat, a Qu from CM Kosemen’s book All Tomorrows, chimes in. It says, “we could genetically modify some people.” Panel 3: the passenger seat friend turns to the backseat and says, “nah, man. Why do you keep saying that?” The Qu says, “my bad.”
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David Hofer @hofer.bsky.social · 21/04/2026
@jtkantor.bsky.social I’m at the game tonight with a Belgian friend. Could you play Papaoutai by Stromae for him?
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David Hofer @hofer.bsky.social · 17/04/2026
I forgot to post this at the time, but a cat sitter recently got the all time best action shot of Hamburg
My cat Hamburg playing with a wand toy
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Jessica Elgot @jessicaelgot.bsky.social · 15/04/2026
Quite a flex to turn up at the presidential palace, get him to confirm you as prime minister, call him unfit to serve with no moral authority, tell him to resign, and then pose for a picture
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David Hofer @hofer.bsky.social · 23/03/2026
Cat timeline cleanser: My cat sitter recently got both an action shot of Hamburg and a closeup of Toledo
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David Hofer @hofer.bsky.social · 23/03/2026
New GenHub post: Cloning a combinatorial library into a plasmid, and viewing the result as a sequence graph: www.genhub.bio/blog/2026/3/...
genhub.bio
GenHub
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David Hofer @hofer.bsky.social · 16/03/2026
Oh, they’re having trouble getting spice off Arrakis? The emperor better go there himself to take charge of things
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David Hofer @hofer.bsky.social · 11/03/2026
The most relaxed cat in the world, currently. I can’t move. Don’t send help
My cat Hamburg asleep against my leg on my footstool
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David Hofer @hofer.bsky.social · 06/03/2026
My cat Hamburg has a pretty excellent diamond pattern by his shoulder blades
My cat Hamburg sleeping against my leg
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Athens Grease @athensgrease.bsky.social · 03/03/2026
fuck, I’m sorry, I can’t compete with this
An ad on the side of a truck advertising “man cereal,” with the slogan CEREAL GOT ITS BALLS BACK
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David Hofer @hofer.bsky.social · 24/02/2026
For non-bioinformaticians, here’s Toledo on the lookout for birdies, and warmer weather
My cat Toledo looking out the cat door
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David Hofer @hofer.bsky.social · 24/02/2026
GenHub (my company) was at FOSDEM (an open source conference) this year. We presented on gen and GenHub for the computational biology track. Check out the video here! fosdem.org/2026/schedul...
fosdem.org
FOSDEM 2026 - Gen: Git for genomes
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auntietiffa.bsky.social @auntietiffa.bsky.social · 10/02/2026
Everybody knows that Pupper just won Downhill Gold
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Rodney Brooks @rodneyabrooks.bsky.social · 06/02/2026
We've known for a while that Waymo has remote people in the loop (they were overwhelmed with "no green light" exec decisions during the Dec 20 SF power failure), but we did not know that many of them are in the Philippines--suggests a large scale contingent. futurism.com/advanced-tra...
futurism.com
It Turns Out That When Waymos Are Stumped, They Get Intervention From Workers in the Philippines
During a Congressional hearing, Waymo's chief safety officer, Mauricio Peña, was grilled over the company's reliance on overseas workers.
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David Hofer @hofer.bsky.social · 02/02/2026
Saw some lovely offshore wind farms flying out of Amsterdam today
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Wrong Station @thewrongstation.bsky.social · 02/02/2026
DOCTOR: I told him he needed to get out to a show, that was how he would cure his depression. CHOTINER: So you learned this technique in school? DR: No, not— listen it was good advice. Pagliacci was in town. C: Right. Is it standard to give advice before learning a patient’s name? DR: Now look
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lauren @lauren.rotatingsandwiches.com · 26/01/2026
new york magazine has a very nasty article out about my beautiful golden throne, which they say is the only thing keeping me alive. when I'm sitting on my big beautiful throne I am NOT ASLEEP!! I am directing the beacon of the astronomican, something sleepy joe did very badly may I add
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Lauri Myllyvirta @laurimyllyvirta.bsky.social · 13/01/2026
NEW: Coal-fired power generation fell in both China and India in 2025, for the first time since 1973. The drop came after record clean energy additions in both countries, and was the first time that clean energy was a major driver of falling coal power use.
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David Hofer @hofer.bsky.social · 07/01/2026
I’m digitizing some records I came into possession of. Toledo is fascinated with the turntable
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John Bull @garius.bsky.social · 06/08/2024
The Dickin Medal is the highest award that can be issued to animals in British military service. Bearing the words "We Also Serve" it has been awarded 75 times since its creation in 1943. Only one cat has ever received the award. This is the story of Able Seacat Simon, of HMS Amethyst. 🧵 1/25
a slightly grumpy looking tuxedo kitty, lounging in a wood tray filled with straw, with a medal round his neck.
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Paul Fairie @paulisci.bsky.social · 22/12/2025
The 2025 Headline of the Year Nominees 🧵
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David Hofer @hofer.bsky.social · 27/12/2025
I am a Tesla owner with grievances against the CEO, and there are multiple things about the car that suck in winter—I have a list. But you can bring it to a stop in six inches of fresh powder, and start it up again, and it moves forward with almost no problem. The dual axle motors are marvelous
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David Hofer @hofer.bsky.social · 25/12/2025
I guess this platform is getting a bunch of new ex-twitter Japanese users? Here’s my entry for the cat club #Blueskyねこ部
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Possum Acquainter @possumacquainter.bsky.social · 19/12/2025
frodo: "gandalf.. could we not have tom bombadil carry the ring?" gandalf, wincing slightly, sighing pissedly, rubbing the bridge of his nose: "tom is.. extremely high"
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