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David Hofer

@hofer.bsky.social
337 followers 95 following 301 posts

I work on software for tracking genome sequences, edits and variants. Cat dad. Boston, MA

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David Hofer @hofer.bsky.social · 05/10/2026
White beans + carrots + onion + diced tomatoes, vegetable or chicken stock, cumin + thyme + oregano + paprika. Add chopped sausage if you want meat
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depths of wikipedia @depthsofwikipedia.bsky.social · 02/10/2026
The Phantom of Heilbronn, also referred to as the Woman Without a Face, was a presumed female serial killer whose existence was inferred from DNA evidence found at 40 crime scenes across Austria, France and Germany from 1993 to 2009.

In March 2009, investigators concluded that the supposed serial killer did not exist, and the DNA belonged to a woman who worked at a factory that made the cotton swabs used for collecting DNA samples
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David Hofer @hofer.bsky.social · 01/10/2026
Love the tusks
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Sarah Andersen @sarahseeandersen.bsky.social · 26/08/2026
The image is of a four panel comic.
The title above the first two panels reads, "Dog Toys".
The first panel shows Sarah, the protagonist, holding a bone shaped dog toy. She says, "Look!"
The second panel shows a dog wagging its tail. There is a speech bubble leading back to Sarah saying "It squeaks!"
The title above the last two panels reads, "Cat Toys".
In panel three we see Sarah again. She says "Come, child."
Panel four shows a cat raising its paws in glee. We see Sarah's hands holding cat nip. We see a speech bubble leading back to Sarah saying "It is time to do drugs".
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David Hofer @hofer.bsky.social · 27/09/2026
Was at the world cycling championship women’s elite race in Montreal today. Demi Vollering won; I got a picture of her and the top three finishers on the last lap. One thing they don’t show on TV is the sweep car
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Keifer @dannyvegito.bsky.social · 13/01/2026
[guy who can’t fully remember that Gramsci quote] it’s Monster Time
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David Hofer @hofer.bsky.social · 07/09/2026
Toledo is enjoying a nap
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David Hofer @hofer.bsky.social · 06/09/2026
Turkeys (the bird) are named in most languages after the place they are believed to have come from. In England they were imported from the Ottoman Empire. In Turkey, they are called “Indias”. In India, they are called “Perus”.
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David Hofer @hofer.bsky.social · 06/09/2026
If you haven’t already, you should watch Lower Decks. They have a conspiracy theory guy
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David Hofer @hofer.bsky.social · 05/09/2026
Sorry, Thomas
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David Hofer @hofer.bsky.social · 04/09/2026
I was wondering if those free hours of electricity at midday would have an effect, seems like it might have
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David Hofer @hofer.bsky.social · 02/09/2026
The act of a cognitively challenged individual
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David Hofer @hofer.bsky.social · 01/09/2026
Crap, I emphasized the wrong syllable, you’re correct
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David Hofer @hofer.bsky.social · 01/09/2026
Now I’m double checking and heard one pronunciation video that kind of collapses it into “knife” (or “knieef”), so maybe it’s shifting
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David Hofer @hofer.bsky.social · 01/09/2026
It’s related to “naive” and “native”, from a Latin word roughly meaning “born”, as in “just born” (naive/ignorant) or “born there” (native).
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David Hofer @hofer.bsky.social · 01/09/2026
I believe I heard you say it like “knife”, but it’s NIGH-eef
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David Hofer @hofer.bsky.social · 01/09/2026
I hate to report this, but fyi I was listening to one of your podcasts today and I think maybe you mispronounced “naif”
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David Hofer @hofer.bsky.social · 31/08/2026
Went hiking in the Adirondacks this weekend, then hung out by a river
Me in front of the summit of Haystack mountainMy feet on the sand by a river
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David Hofer @hofer.bsky.social · 25/08/2026
Wout’s hair looking good!
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David Hofer @hofer.bsky.social · 24/08/2026
The “I tell you what, hooman” pose
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David Hofer @hofer.bsky.social · 24/08/2026
My solar + electric system just crossed over to being a net exporter for the year to date. It’ll probably go back to being a net importer in November or December, but I’m enjoying it for now
My solar electric system production/import/export numbers for the year
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David Hofer @hofer.bsky.social · 24/08/2026
30 years ago people were freaking out about future overpopulation and how we’d feed everyone
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David Hofer @hofer.bsky.social · 20/08/2026
Seems like we’re at chud 6.3 or 7.2 at this point
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David Hofer @hofer.bsky.social · 19/08/2026
I think he’d write every column about how Biden is to blame for something, if they’d let him
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David Hofer @hofer.bsky.social · 19/08/2026
Restitution for Bennet, who landed on his feet as the U.S. political columnist for The Economist? Wtf
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Ramin Nasibov @nasibov.me · 12/08/2026
If you missed the solar eclipse, this is what it looked like:
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David Hofer @hofer.bsky.social · 12/08/2026
What about maybe Emperor Valerian vibes? Or Crassus? I know these people respect the ancient Romans
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David Hofer @hofer.bsky.social · 12/08/2026
If you would like an informative post on organoids (not specifically neural ones), this one is great: www.owlposting.com/p/why-havent...
owlposting.com
Why haven't organoids solved all of drug discovery?
5.8k words, 26 minutes reading time
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David Hofer @hofer.bsky.social · 07/08/2026
Love Song by Sarah Bareilles is such an awesome fuck you to the record label
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David Hofer @hofer.bsky.social · 04/08/2026
Noted!
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David Hofer @hofer.bsky.social · 04/08/2026
It was covered on electoral-vote.com yesterday. One of many reasons it’s my primary source for political news. www.electoral-vote.com/evp2026/Sena...
electoral-vote.com
Electoral-vote.com
Track the 2026 Senate election with a red/blue map of the US updated daily using the latest state polls.
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David Hofer @hofer.bsky.social · 02/08/2026
www.heraldnews.com/story/news/l...
heraldnews.com
Bordalo II: The man and ideals behind New Bedford’s new Plastic Rooster sculpture
About 880 pounds of waste materials were pieced together by Portuguese artist Bordalo II to give shape to New Bedford's newest public art exhibition.
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David Hofer @hofer.bsky.social · 02/08/2026
Was in New Bedford today, they have a huge awesome sculpture of a rooster made from discarded materials and trash
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David Hofer @hofer.bsky.social · 31/07/2026
If it were a lab leak (which it seems not to be), what would satisfy them? The Chinese government saying, “Oh, our bad, sorry”? All scientists promising not to do directed evolution? I struggle to see any rational goal in them pursuing this
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David Hofer @hofer.bsky.social · 30/07/2026
And yes, I am referencing the low-level command that Data discovered
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David Hofer @hofer.bsky.social · 30/07/2026
No, they want to sleep too much of the time
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scare-cadus (is this anything) 🎃 @birdapp.rip · 29/07/2026
A scene from The Odyssey where Penelope stands before the suitors, but Tim Robinson has been added in. It’s a reference to I Think You Should Leave. Penelope says “Ronnie, I feel like you’re just here for the zip line” and Tim Robinson says “what?”
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David Hofer @hofer.bsky.social · 25/07/2026
Lowe has been posting things like this about once a month, but this particular one is more pointed than usual, and I appreciated it
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David Hofer @hofer.bsky.social · 21/07/2026
Not my original thought, but being defeated by the baby you washed is getting close to Greek tragedy
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Brendel @brendelbored.bsky.social · 19/07/2026
Vanquished by the baby you washed is some Athena bullshit
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David Hofer @hofer.bsky.social · 16/07/2026
I’ve realized Boston will never go on Atlantic time because half the people want the current amount of daylight in the morning, and I think my ideal place to live may be the Upper Peninsula in Michigan, for the cooler summers and later sunsets
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Adam Serwer @adamserwer.bsky.social · 15/07/2026
Messi goes super saiyan in the last 20 of every match and every opposing coach is like, what if he didn’t and we could just defend a narrow lead until the whistle
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The Life of Sharks @thelifeofsharks.com · 04/07/2026
Saw this ad for a goat on Facebook. It’s perhaps the greatest advert I’ve ever read. It’s just superb.
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David Hofer @hofer.bsky.social · 06/07/2026
Just read this morning there’s an effort to get rideshare drivers in Massachusetts to use EVs because they drive far more miles on average than anyone else, and I like how pragmatic my state is, overall
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Mrs Frog @musettedutour.bsky.social · 06/07/2026
Stage 2 Tarragone to Barcelone - After you, youngster #letourdepoupees #couchpeloton #sbscycling #TDF2026
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Mrs Frog @musettedutour.bsky.social · 05/07/2026
Stage 1 Barcelone to Barcelone - Stocking up for a hot TTT #letourdepoupees #couchpeloton #sbscycling #TDF2026
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TW @twesq.bsky.social · 02/07/2026
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David Hofer @hofer.bsky.social · 01/07/2026
How lovely to see an effective, well financed campaign to get people who support renewables into obscure offices that will let them make policy in favor of renewables
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Commercial Solar Guy @commercialsolarguy.com · 29/06/2026
“Comparing 1 acre of growing corn for ethanol, to 1 acre of solar panels to charge EVs”
Bar chart comparing annual vehicle miles per acre for corn versus Solar with the Solar being about 70 times greater
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Marie Le Conte @youngvulgarian.marieleconte.com · 27/06/2026
absolute height of comedy is when they cut to the goal and you see how many kid keepers they've got
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