Sign in

Gyana Prakash Mahapatra

@gyanaprakash.bsky.social
560 followers 661 following 10 posts

Ph.D Student @Schuller Lab in Marburg University | Structural Biologist | #Microbiology🦠 #Biochemistry🧬 #CryoEM/ET❄🔬 🇮🇳->🇨🇦->🇩🇪

PostsRepliesMedia
Reposted by Gyana Prakash Mahapatra
Manon Demulder @manondemulder.bsky.social · 02/10/2026
If you’ve always been curious about how algae fix carbon, @phaips.vd.st, @cellarchlab.com and I have put together the quickest route into pyrenoids. And if you don’t feel like reading at all, we have an accompanying poster doi.org/10.1242/jcs....
06224
Reposted by Gyana Prakash Mahapatra
Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
1023696
Reposted by Gyana Prakash Mahapatra
Matt Johnson @profmattjohnson.bsky.social · 06/09/2026
Great to share our new preprint on Chlamy’s chloroplast ATP synthase at 2.2 Å we see 13 c subunits, a modified redox regulation and a complete Grotthuss proton wire 🦠☀️ www.biorxiv.org/content/10.6...
biorxiv.org
A 13-subunit c-ring in the Chlamydomonas chloroplast ATP synthase lowers the H⁺/ATP cost of carbon fixation
The chloroplast F1Fo ATP synthase is a rotary motor that converts the light-driven proton-motive force into the chemical energy of ATP. The number of c-subunits in its rotor fixes the number of proton...
0102
Reposted by Gyana Prakash Mahapatra
Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026
Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...
215450
Gyana Prakash Mahapatra @gyanaprakash.bsky.social · 28/07/2026
Come join us! If you’re interested in structural biology and photosynthesis, this is a great opportunity.
011
Reposted by Gyana Prakash Mahapatra
Bui Lab @McGill @builab.bsky.social · 23/07/2026
Exciting new work from Elaine Wang, PhD student co-supervised with Natalie Zeytuni! Check out their latest structural insights into native Type V fimbriae from Porphyromonas gingivalis: www.biorxiv.org/content/10.6...
biorxiv.org
Structural tuning of native type V fimbriae shapes mechanical specialization in Porphyromonas gingivalis
Bacterial fimbriae are central to adhesion, colonization, and biofilm formation, yet how related fimbriae systems are structurally and mechanically specialized within the same pathogen remains poorly ...
011
Reposted by Gyana Prakash Mahapatra
Tanmay Bharat @tbharat-lab.bsky.social · 15/07/2026
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
28535
Reposted by Gyana Prakash Mahapatra
Gregor Weiss @weiss-lab.bsky.social · 10/07/2026
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
311527
Reposted by Gyana Prakash Mahapatra
Sophia Paul @sophia-pa.bsky.social · 08/07/2026
Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...
37024
Reposted by Gyana Prakash Mahapatra
trisre.bsky.social @trisre.bsky.social · 06/07/2026
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
23215
Gyana Prakash Mahapatra @gyanaprakash.bsky.social · 27/06/2026
Excited to share our new preprint! How does the cyanobacterial hydrogenase HoxEFUYH drive photosynthetic H₂ production? Using #cryoEM, biochemistry, FTIR and EPR spectroscopy, we reveal its molecular mechanism, including the basis of electron bifurcation/confurcation. www.biorxiv.org/content/10.6...
biorxiv.org
Electron confurcation drives photosynthetic H2 production in cyanobacteria
Cyanobacteria are major contributors to global photosynthesis and are intensively studied for sustainable green H2 production. Central to this process is the bidirectional [NiFe]-hydrogenase HoxEFUYH,...
1115
Reposted by Gyana Prakash Mahapatra
Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 01/06/2026
🛠️💉It's time for engineering contractile injection systems! @chipericson.bsky.social & @davidschaumann.bsky.social introduce programmable CIS - PROCIS, combining tail length control, non-native cargo loading, and cell retargeting all in one system! www.biorxiv.org/content/10.6... 🧵 1/5
26429
Reposted by Gyana Prakash Mahapatra
Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
6313118
Reposted by Gyana Prakash Mahapatra
joe dobbs @joedobbs.bsky.social · 22/04/2026
Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...
15718
Reposted by Gyana Prakash Mahapatra
Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 16/04/2026
Photosynthetic bacteria helped shape Planet Earth. Among them cyanobacteria—microbes that produced the oxygen in Earth’s atmosphere & made complex life possible. They have captivated scientists for decades by offering insights into how life evolved from single cells into multicellular organisms.
Fluorescent Anabaena. Fluorescently labelled CorM filaments inside Anabaena. These represent a newly discovered cytoskeleton in multicellular cyanobacteria. © Loose group
23515
Reposted by Gyana Prakash Mahapatra
ASM @asm.org · 15/04/2026
Cyanobacteria are an ancient clade of phototrophic prokaryotes. But out of all the cyanobacteria available, why did Synechocystis sp. PCC 6803 become the default laboratory model? This #JBacteriology review offers insights: asm.social/2TD
Overview of key research directions using Synechocystis sp. PCC 6803 as a model cyanobacterium. Summary of the main structural, physiological, genetic, and behavioral characteristics that have established Synechocystis sp. PCC 6803 as a leading model organism for cyanobacterial research. Core cellular functions include oxygenic photosynthesis, carbon, and nitrogen metabolism. Emerging research directions focus on primary metabolism and regulatory and adaptive processes, such as stress responses, circadian clock, behavior, and biotechnological applications.
22311
Reposted by Gyana Prakash Mahapatra
Tomas Pascoa @tomaspascoa.bsky.social · 14/04/2026
1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
510237
Reposted by Gyana Prakash Mahapatra
Anuj @rnfr2d2.bsky.social · 14/04/2026
How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...
biorxiv.org
12714
Reposted by Gyana Prakash Mahapatra
Bui Lab @McGill @builab.bsky.social · 12/04/2026
The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel
25013
Reposted by Gyana Prakash Mahapatra
Debnath Ghosal @debnathghosal.bsky.social · 12/04/2026
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶‍♂️
310840
Gyana Prakash Mahapatra @gyanaprakash.bsky.social · 29/03/2026
Excited to share our new paper in @natcomms.nature.com ! Here, we present the cryo-EM structure of the Cytc₆:PSI complex from Chlamydomonas reinhardtii👇 www.nature.com/articles/s41...
1369
Gyana Prakash Mahapatra @gyanaprakash.bsky.social · 26/03/2026
Huge congratulations, @rnfr2d2.bsky.social !!! 🎉🏆 This is such a well-deserved recognition of your hard work and the incredible science behind your PhD.
191
Reposted by Gyana Prakash Mahapatra
Sven T. Stripp @stripplab.bsky.social · 24/03/2026
Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...
1178
Reposted by Gyana Prakash Mahapatra
Ben Engel @cellarchlab.com · 25/09/2025
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on! #TeamTomo #PlantScience 🧪 🧶🧬 🌾 elifesciences.org/articles/105... 1/🧵
313643
Reposted by Gyana Prakash Mahapatra
cryoEM papers @cryoempapers.bsky.social · 09/09/2025
Cryo-EM structure of Chlamydomonas Photosystem I complexedwith the alternative electron donor cytochrome c6 www.biorxiv.org/content/10.1101/2025.09.08.674899v1 #cryoEM
162
Reposted by Gyana Prakash Mahapatra
Alexey Amunts @amunts.bsky.social · 07/07/2025
Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence www.biorxiv.org/content/10.1...
14410
Reposted by Gyana Prakash Mahapatra
Sven T. Stripp @stripplab.bsky.social · 26/06/2025
Let's unpack what our new ferredoxin paper is about, shall we? ✨ She et al., Adv. Sci. (2025) doi.org/10.1002/advs...
media.tenor.com
a cartoon drawing of a genie holding a snake and a boat
ALT: a cartoon drawing of a genie holding a snake and a boat
1103
Reposted by Gyana Prakash Mahapatra
Misha Kudryashev @mishakudryashev.bsky.social · 08/06/2025
We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
410734
Reposted by Gyana Prakash Mahapatra
Schuller Jan @schullerjm.bsky.social · 04/06/2025
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social . www.biorxiv.org/content/10.1101/2025.06.02.657420v1
36825
Reposted by Gyana Prakash Mahapatra
Sven T. Stripp @stripplab.bsky.social · 21/05/2025
Ross @milton-group.bsky.social came up with a very similar idea: how about introducing cyanophenylalanine to a (bacterial) ferredoxin that binds two [4Fe-4S] clusters? One might learn where the electron resides as most ferredoxins are considered one-electron redox mediators... 🧵
173
Reposted by Gyana Prakash Mahapatra
Matt Johnson @profmattjohnson.bsky.social · 21/05/2025
Pleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol 🌞🌱 rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
rdcu.be
Structure, regulation and assembly of the photosynthetic electron transport chain
Nature Reviews Molecular Cell Biology - The electron transfer chain in chloroplast thylakoid membranes uses solar energy to produce NADPH and ATP, which power carbon fixation into biomass. This...
01712
Reposted by Gyana Prakash Mahapatra
Schuller Jan @schullerjm.bsky.social · 12/05/2025
Happy to present the lab latest work, today from the green-side. The ultimate PSII assembly intermediate that directly precedes incorporation of the Mn4O5Ca cluster and formation of the OEC. Psb32 binds to PsbV, challenging the assumption the extrinsic subunits all associate spontaneously in-vivo.
33714
Reposted by Gyana Prakash Mahapatra
Oli Clarke @olibclarke.bsky.social · 10/04/2025
I know there are more important things to worry about right now... but it really pisses me off coming across things like this in the literature. Nominally 4.8 Å map... check out Fig S1 😬 (also check out any other #cryoem paper by same group, ~all in BBRC) www.sciencedirect.com/science/arti...
55412
Reposted by Gyana Prakash Mahapatra
Schuller Jan @schullerjm.bsky.social · 17/04/2025
Do you want to join the team? I just got awarded a 2 year fully funded Postdoc position to investigate the metabolism of anaerobic pathogenic bacteria. If you have a strong background in protein biochemistry or anaerobes shown by solid publications, reach out. Job add follows, please repost.
098
Reposted by Gyana Prakash Mahapatra
Anuj @rnfr2d2.bsky.social · 16/04/2025
For decades, how methanogenic archaea activate the MCR complex to produce methane remained a mystery. Today in Nature, we report the high-resolution cryo-EM structure of the MCR activation complex! www.nature.com/articles/s41...
nature.com
Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature
The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...
25217
Reposted by Gyana Prakash Mahapatra
Anuj @rnfr2d2.bsky.social · 07/03/2025
Excited to share our latest work on the structure and mechanism of the ancient sodium-pumping Rnf complex. www.nature.com/articles/s41...
nature.com
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery - Nature Communications
The Rnf complex is a key respiratory enzyme of anaerobes and nitrogen-fixing bacteria. Here, the authors combine structural, computational, and biochemical experiments to probe the unique redox-couple...
181
Reposted by Gyana Prakash Mahapatra
Tomas Pascoa @tomaspascoa.bsky.social · 13/11/2024
First bluesky post! About time. This week, our manuscript revealing the structure, inhibition, and mechanism of human Ceramide Synthase 6 was finally published in NSMB. We combined cryo-EM and mass spectrometry to reveal its ping-pong mechanism. Check it out! doi.org/10.1038/s415...
1395
Reposted by Gyana Prakash Mahapatra
Jon Jerlström Hultqvist @jonhultqvist.bsky.social · 11/11/2024
Want to be amazed by how a symbiont can be located at the center of a cell while still being an epibiont! Please read and be amazed by the symbiosis between Anaerameoba and sulfate-reducing bacteria! Now out in Nature Communications (open access)! rdcu.be/dZGNe (1/11)
rdcu.be
A unique symbiosome in an anaerobic single-celled eukaryote
Nature Communications - Symbiont-housing structures are well-studied in multicellular eukaryotes but rarely in unicellular protists. This study shows that low-oxygen-adapted Anaeramoebae have...
55627