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Ryan Gutenkunst

@ryangutenkunst.bsky.social
1.1K followers 1.6K following 156 posts

Computational population geneticist, evolutionary systems biologist, Department Head, educator, mentor, father, husband, triathlete, alpine skier. gutengroup.mcb.arizona.edu Views expressed are my own, not those of my employer.

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Reposted by Ryan Gutenkunst
Alex Palazzo @ribonucleicacids.bsky.social · 16/10/2026
Just back from Japan. What a trip. One of the highlights was meeting Tomoko Ohta. She is one of the most important figures in the history of the life sciences, but few outside of the field of molecular evolution know of her or her work.
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Ezra Levin ❌👑 @ezralevin.bsky.social · 17/10/2026
Full update from our team. We STILL do not have admin access to the account.
The No Kings Instagram account has been reactivated, but administrators have not yet regained access.

We now know that Meta pulled down the account. For approximately 90 minutes, Meta did not respond to our team, even as the account was offline at the peak of our national day of action and livestream. The account is now viewable again, and Meta told us in their response email that they made a bad call.

However, administrators are still unable to access the account, blocking our ability to post about an ongoing day of mass action for early voting. Meta is currently not allowing the team to log in using the No Kings email address originally associated with the account. The team is troubleshooting that issue now.
This is not OK.

This is part of a much bigger concern: activists and movements around the world are increasingly vulnerable to decisions made by powerful technology platforms that can determine who gets heard and who gets silenced.

We will close the loop once our team is fully back in the account. This remains a developing situation.
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Jim Faeder 🌈🐈‍⬛🐈⚽️ @jimfaeder.bsky.social · 16/10/2026
Just out this week: Yonosh KA, Faeder JR. Mathematical modeling of processive Ras activation by SOS reveals a general mechanism for digital signaling. npj Systems Biology and Applications (2026). Link: www.nature.com/articles/s41...
nature.com
Mathematical modeling of processive Ras activation by SOS reveals a general mechanism for digital signaling - npj Systems Biology and Applications
npj Systems Biology and Applications - Mathematical modeling of processive Ras activation by SOS reveals a general mechanism for digital signaling
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Manny Ares 👀 @mannyares.bsky.social · 16/10/2026
⚠️ Another problematic NIH policy needs your attention ⚠️ NOT-OD-26-112: grants.nih.gov/grants/guide... Redefines transient expression as "genetic modification". If adopted, mRNA medicines could be forbidden. Comments close October 19! Please go comment on this! osp.od.nih.gov/comment-form...
Screenshot of concerning policy proposal redefining "genetic modification".
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alex ioannidis @alexgioannidis.bsky.social · 08/10/2026
My group's paper out on the cover of Science! Native Hawaiians are most closely related to the Rapanui of distant Easter Island 😮 Proud of my students the two co-first authors Cole Shanks & former MS student Edward Huang and 3rd author group member Chris Thomassin. www.science.org/eprint/4HAYG...
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Anne Carpenter @drannecarpenter.bsky.social · 16/10/2026
Come work with me! TT Professor opening at Purdue University; Quantitative Neuroscience! I’d love to recruit someone working on high throughput image data. It's a great place to be, Purdue is a top-30 US university (12th among public universities): careers.purdue.edu/job/Assistan...
careers.purdue.edu
Assistant/Associate Professor in Biological Sciences
Assistant/Associate Professor in Biological Sciences
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Matthew Buckley @physicsmatt.bsky.social · 27/09/2026
Turns out the only unit on campus that is making a profit is central administration. And you're not going to believe this, but that's the unit who gets to decide the formula for how profitability of an academic unit is calculated.
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Julie S. Lalonde @julieslalonde.bsky.social · 14/10/2026
Being GenX/Millennial is such a trip. In our lifetimes, we saw people our age getting wild criminal penalties for pirating music and now have to sit and watch as companies gobble up our work with impunity.
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Katie Spoon @kspoon.bsky.social · 14/10/2026
Although formal DEI practices and programs in the US have largely been dismantled, your interactions with your colleagues still matter, and our paper suggests they may matter a lot more than you may think.
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Katie Spoon @kspoon.bsky.social · 14/10/2026
We found that the most gendered experience wasn’t work-life balance, the focus of most retention efforts. It was feeling devalued, in formal evaluations, but particularly in everyday interactions. Unlike every other topic, the gender gap in devaluation was larger among more senior faculty.
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Morgan Johnson @poormojo.bsky.social · 14/10/2026
No joke. I think this is the most important video I have ever seen about mobile games. This guy breaks down how this game psychologically profiles you, and makes the game harder or easier in order to show you ads
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Tim Hsu @timhsu.net · 14/10/2026
PSA: For anyone writing a recommendation for the NSF grad fellowship this year, recs are due on Fri Oct 16, 8pm Eastern, cleverly *before* the actual application deadline. This tidbit isn't on the NSFGRF front page anymore; it's buried inside the program solicitation:
From the NSFGRF program solicitation:

Reference letters are due Friday, October 16 by 8:00 p.m. Eastern Time (ET). Reference letters must be submitted through the NSF Reference Letter System in Research.gov and will not be accepted after 8:00 p.m. ET.
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Brian J. Enquist @bjenquist.bsky.social · 14/10/2026
Please pass along - my department @uofa-eeb.bsky.social is hiring! Assistant Professor in quantitative population and community ecology - come join us in wonderful #Tucson ! #AcademicJobs 🧪🌾🌐 arizona.csod.com/ux/ats/caree...
arizona.csod.com
Assistant Professor of Quantitative, Population, and Community Ecology (T/TE)
Establish and maintain a competitive research program.Teach at the undergraduate and graduate levels and contribute to mentoring and supporting studen...
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NY Times Pitchbot @nytpitchbot.bsky.social · 13/10/2026
The largest single Republican donor owns the platform X and uses it to spread false rumors about Democratic candidates. Here's why Bluesky has an intellectual diversity problem.
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Brian J. Enquist @bjenquist.bsky.social · 13/10/2026
Potential postdoc and PhD options please pass along. Thrilled to be a part of this - We will be advertising soon for a quantitative position in community, ecosystem, forest ecology and demography. 🧪🌾🌐
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Bernard Kim @bernardkim.bsky.social · 12/10/2026
Please share: we will be hosting a Zoom webinar Q&A on Thursday, Oct 15 at 1 PM ET to answer any questions you may have about our department's Assistant Professor job posting. Registration is not required. princeton.zoom.us/j/91471573963
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Dan Garisto @dangaristo.bsky.social · 12/10/2026
AIP FYI reports that the executive order renaming artificial intelligence will be applied at the grant level as well, though not retrospectively.
NSF grants will be rewritten for “super intelligence”
A National Science Foundation official said agency grants will be rewritten to alter references to artificial intelligence to “Super Intelligence”, following a White House executive order. Speaking at a Directorate for Mathematical and Physical Sciences webinar on Wednesday, division deputy directorate head Junping Wang said, “your program director may work with you by changing AI to SI,” in grant abstracts and related documents. Internal AI tools at the agency may summarize some grant submission materials, he added, “but not for making recommendations.”
Renaming existing grant materials would go beyond requirements in the September executive order. At the National Institutes of Standards and Technology, for example, a recent Super Intelligence update echoed the order by noting that it does not require “the alteration of previously issued regulations, Presidential actions, contracts, grants, or other historical documents.”
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Basil Greber @bjgreber.bsky.social · 12/10/2026
I knew it was time to bring out the good stuff when my phone camera started capturing odd colours in the sky: A few shots from last Saturday's #aurora extravaganza in the UK.
A four-panel image with photos showing the night sky lit up by pink and green auroras. Top left: Entrance to an old farm building; top right and bottom left: a small boat stranded on land, surrounded by water puddles, against a yellow, pink, and deep blue sky; bottom right: view of a farm building at night with green and purple aurora in the background.
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Gustavo Valadares Barroso @gvbarroso.bsky.social · 09/10/2026
Phylogenetic conservation scores have long been used to identify selection targets in the genome. With machine learning, they take a new form and will likely grow in popularity. @apragsdale.bsky.social and I investigate their relationship with mutation rates www.biorxiv.org/content/10.6...
biorxiv.org
Strong correlations between mutation rates and selective constraint in the human genome?
The 21st century has seen repeated challenges to the premise that de novo mutations occur independently from their fitness effects. So far, these attempts have been dismissed as technical artifacts, r...
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Richard Sever @richardsever.bsky.social · 11/10/2026
Autonomous AI agents discover reverse transcriptases with tandem repeat arrays - Anthropic paper now on bioRxiv www.biorxiv.org/content/10.6...
biorxiv.org
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Jonathan Z Simon @jzsimon.fediscience.org.ap.brid.gy · 11/10/2026
#NeuroJobs #ComputationalNeuroscience Faculty position in Computational Neuroscience, Assistant or Associate Professor, at the University of Maryland (please boost): “The Department of Biology at the University of Maryland, College Park (UMD), invites applications from individuals using […]
fediscience.org
Original post on fediscience.org
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Ryan Gutenkunst @ryangutenkunst.bsky.social · 11/10/2026
Love Taylor, but brutal to watch Solveig crumble like that. Glad she walked it in; hopefully no long-term consequences.
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Jess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 10/10/2026
I use this example in classes as showing how DNA sampling is very good at answering "who touched this sample", but not necessarily "and who therefore committed this crime"
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Urban Cycling Institute @urbancyclinginstitute.org · 10/10/2026
Who is the most efficient traveler? Step 1: find the cyclist on the graph Step 2: 🤯 This is the efficiency of locomotion in calories per gram per kilometer, as measured by @sciam.bsky.social
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Tom Gauld @tomgauld.bsky.social · 10/10/2026
My latest @newscientist.com cartoon
Panel 1: a large robot (composed of AI servers, network switches, storage arrays, and power distribution units) and a human are talking.

Professor "You don't want to destroy humanity do you, lLLM-A-9300x?"

Robot "Haha. What a silly question, Professor. I have no desires or feelings of my own whatsoever."

Professor (relieved)"Oh good." 

Panel 2: they walk on. The robot continues  "I am merely a tool of the company that created me. And that company, being composed of humans, will naturally have humanity's best interests at heart."

Panel 3: The professor is conspicuously quiet.
"Right?" says the Robot.
…
More silence

"Professor?"
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Steven Strogatz @stevenstrogatz.com · 10/10/2026
I chatted with @radiolab.bsky.social about math and AI – hope you enjoy the conversation radiolab.org/podcast/math...
radiolab.org
Math Vs Machine
Machines are answering our hardest problems. Does it matter if we don’t understand how?
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Jeremy Berg @jeremymberg.bsky.social · 09/10/2026
For the win! 🎉🎉🎉🎉🎉
A response to President Trump calling anyone who uses the term "Artificial Intelligence" the enemy:  I'm sorry, but I believe in calling Artificial Intelligence by its name given at birth. I'm not participating in this woke nonsense.
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SMBC Comics @smbccomics.bsky.social · 09/10/2026
The president is actually doing the same thing in the third to last panel. COMIC ◆ www.smbc-comics.com/comic/bet-2 PATREON ◆ www.patreon.com/ZachWeinersm... STORE ◆ smbc-store.myshopify.com
Part 1/2 of a 7-panel SMBC comic update. A generic version of an American president leans grimly over his desk, stating "we have no cards left to play. It is loss or stalemate. We launch the nuclear arsenal. Now." He then talks about the effects of the fallout for 2 panels: "once our strike is inbound, our foes will return fire. Billions, unsuspecting, reduced to shadows on a concrete wall. In the years that follow, crops will wither under a bituminous sky. And those children who survive infancy will forever bear the mark of the atom in their blood and tissues."Part 2/2 of a 7-panel SMBC comic update. The president concludes "Whatever world emerges, civilization shall not." An employee standing behind him asks "mr. president, I ask you to hesitate. Just for a moment." The president grants him 5 minutes, during which the employee bets on a prediction market app on his phone that there will be thermonuclear wold war before the end of the year."
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Jessica Santollo @drjess.bsky.social · 09/10/2026
Our Neuroscience Faculty Position closes in about a week. Please share with anyone you know on the job market! ukjobs.uky.edu/postings/646...
ukjobs.uky.edu
Assistant or Associate Professor of Biology
The Department of Biology at the University of Kentucky invites applications for a tenure-track faculty position at the rank of Assistant or Associate Professor, with expertise in the field of Cell an...
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Steve Huntsman @stevehuntsman.bsky.social · 09/10/2026
arxiv.org/abs/2610.10072
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Ann T. Tate @annttate.bsky.social · 09/10/2026
Please RT: Do you use math to address interesting biological problems? Join us at Vanderbilt BioSci! We are conducting an open-rank TT search in Theoretical Biology: apply.interfolio.com/194619. We are a friendly and collaborative department with interests spanning a range of biological disciplines!
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Rafael Marcondes @rafamarcondes.bsky.social · 01/10/2026
My dept is hiring 2 lecturers, one in cell/molec and the other in comp bio. 100% teaching, no tenure but generous intervals btwn renewals. Same position as me and I love my job!!! Very collegial dept w/ colleagues who take quality teaching v seriously barnard.wd1.myworkdayjobs.com/en-US/Facult...
barnard.wd1.myworkdayjobs.com
Lecturer of Biological Sciences
If you are a current Barnard College employee, please use the internal career site to apply for this position. Job: Lecturer of Biological Sciences Barnard is a premier liberal arts undergraduate coll...
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Kathleen Rhoades @kathleenrhoades.bsky.social · 08/10/2026
excited to add "Artificial Intelligence" to the List of Forbidden Terms for federal grant applications
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Joey Politano🏳️‍🌈 @josephpolitano.bsky.social · 08/10/2026
Again he’s really losing it with the AI stuff now
Donald J. Trump
@realDonaldTrump
+
The White House considers anyone that uses the term, "Artificial Intelligence," as opposed to the highly accepted new and more accurate term,
"Super Intelligence," THE ENEMY! President
DONALD J. TRUMP
2 ReTruths 9 Likes
10/8/26, 12:14 PM
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Ragnar {Groot Koerkamp} @curiouscoding.nl · 08/10/2026
Turns out 3 of the papers have been retracted based on a sign error in one of them. github.com/openai/math/...
3 withdrawals based on a sign error in a paper on the Algebraicity of Weill classes on split abelian eightfolds.
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Sean Carroll @seanmcarroll.bsky.social · 07/10/2026
Doesn't get much more transformational than this (if you're a mathematician). There will still be plenty for humans to do, but the nature of that work is going to be different.
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Mike Yass @mikeyass.bsky.social · 07/10/2026
you cut out the guy's best response:
	
	
philipswood 12 hours ago | prev | next [–]

Honest question: how is this different from some unknown mathematician having a breakthrough?

I mean: if some reclusive Japanese genius had a breakthrough on your problem and published it, would you have felt the same?

And if not, why not?

reply
	
	
jboggan 12 hours ago | parent | next [–]

If that had happened I would be overjoyed, maybe a hair chagrined that I didn't get it myself, but truly happy that someone got it and that I could go and talk to that person. Because it's the kind of problem I don't think would have fallen to a human after a few hours of thought, and I would have so much to talk about with that person. I would fly to Japan and hope to have tea with them, I would learn some Japanese to make the conversations easier. I would learn some interesting things hearing about their struggles and their false starts. I would make friends with that reclusive Japanese genius and my life would be far richer for it.

I will never meet that person and I will never hold a real conversation with the "creator" of that proof. They will never tell me how they came up with the cancelling exponential summation that cracked the constructio
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 07/10/2026
The OPT rule is out, and it's a mess. DHS is aware that this rule will be challenged in court, but didn't even bother to do a defensible analysis of the costs. For example, their estimate of costs that this rule will impose on the public over 10 years is a range between $241 million to $29 billion.
Due to high uncertainty in regulated parties’ behavioral responses, DHS uses ranges to estimate costs and transfers. These ranges reflect different scenarios for how many OPT fees the educational institutions would fund. If all OPT fees are paid by schools, the main impact would be the transfer of payments from the fees. If some OPT fees are not paid by schools due to reduced participation, there would be opportunity costs from the lost OPT participation. DHS estimates the annualized costs of the proposed rule would range from $32 million to $8.2 billion, with a primary estimate of $4.1 billion discounted at 3 percent. Discounted at 7 percent, the estimated annualized costs of the proposed rule would range from $34 million to $8.2 billion, with a primary estimate of $4.1 billion. DHS estimates the 10-year total costs of the proposed rule would be $275 million to $69.9 billion, with a primary estimate of $35.1 billion discounted at 3 percent (see Table 10). Discounted at 7 percent, the estimated total costs of the proposed rule would be $241 million to $57.7 billion, with a primary estimate of $29.0 billion.
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Catherine Rampell @crampell.bsky.social · 07/10/2026
Trump admin's new rule adding prohibitively expensive new fees for "OPT"—temporary work authorization program for international students and new grads in the United States—is out. Would require colleges to pay $70,000 for year one. $30,000 for years two and three combined for STEM fields.
public-inspection.federalregister.gov
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 07/10/2026
"This stands in stark contrast not only to national statistics...but also to UChicago’s peers...The gap between the rates of admissions is widening every single year: It is becoming easier and easier to be admitted to UChicago if you are male rather than female."
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Caroline Bartman @cbartman.bsky.social · 07/10/2026
Mitochondria is powerhouse of cell
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chasingmicrobes @chasingmicrobes.bsky.social · 07/10/2026
biohub.org
Open data for predictive AI models of biology: $1.8 billion committed
Biohub, DOE, NIH, and partners will generate open, standardized data to train AI models that predict how cells respond to interventions.
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crumb @crumb.bsky.social · 07/10/2026
news.ycombinator.com/item?id=4998...
ihoggan 
 I was a graph theory junkie long ago and even moved to Budapest for awhile to study among the greats. While I was there I started working on Barnette's Conjecture which came to occupy my thoughts over the next 24 years of my life, on and off as I worked in many different fields. Last summer I even thought for a few days that I had actually solved it. But it's supposedly proven here - problem 180. I don't know what to think exactly. I spent thousands of hours on that problem. I really enjoyed it. Hearing that it is solved somehow makes me sad in a far-off way, like hearing an ex-girlfriend died suddenly in a car crash. I don't know, there's probably a lot of people feeling odd emotions tonight. There's no Lean proof for this one so I'm digesting the paper. On the surface it looks like an approach I considered 24 years ago and abandoned. 
I revisited the problem this summer, along with my partial solutions, when the previous round of stunning proofs came out. Several hours of work with Fable simply convinced me it wasn't yet solvable and reinforced how hard of a problem it was. 
 WheelsAtLarge
I have very little understanding of higher math, so I ask you: Was the proof due to a type of brute-force solution that could be solved had you gained enough information from reading others' work, or was it more like a proof that was sparked by an insight that came once a clue on how to solve it was put forward? I guess my question is: Was the problem proven by using a collection of everyone's work, or was it due to a brand-new insight? 
reply 
jboggan
 Hi I'm still digesting the proof and translating a bit from the dual case back to the primal in which I most commonly thought about it. I don't think it was a brute force proof in the sense that it combined every possible paper and commentary. It's rather odd because I feel like most of the work on the conjecture was focused on an induction proof based around graph reductions, and this proof avoided those issues entirely by offering a concrete constructive proof of finding a Hamiltonian cycle. Rather, it explicitly selected the edges not in the Hamiltonian cycle, which is in line with previous attempts via the dual. 
The "oho" insight for this is actually f**ing wild, it involves a complex valued exponential sum on the edges. I've seen a lot of clever counting arguments before in graph theory but this is the first time I've seen complex roots and annihilating terms like this, the symbolic manipulation tricks in this look like things out of quantum physics. I don't understand where this trick originated, I need to really digest this. 



jboggan
 I went back to that Fable chat and showed it this new preprint. It coded up the new constructive algorithm and ran it against the existing test suite, that looks good at least. 
It has been super helpful in delineating where the crucial concept came from. The proof is rather simple as graph theory proofs go, but it does seem to use some constructions that would only seem obvious if you had serious physics experience with partition function and calculating energy states that cancel out. It's not a wholly alien bolt from the heavens, but I can also see how there hasn't been a human being with the broad theoretical physics knowledge combined with the deep graph theory experience in planar graphs to come up with this idea. I don't know, I'm looking for precedents of this formulation and some old papers of Penrose counting the number of edge colorings of this same graph type are coming up, the line of argument at least rhymes. But I agree with the thought that this sort of progress should not be siloed inside those companies. I propose a tax so that every slop cannon Al video pays for another hour of compute time for advancing mathematics. 
reply
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 07/10/2026
Pls share:The Department of Microbiology at the University of Georgia invites applications for a tenure track Associate or Full professor position in Medical Mycology, beginning August 1, 2027. www.ugajobsearch.com/postings/508...
ugajobsearch.com
Associate Professor or Professor of Microbiology in Medical Mycology
The Department of Microbiology at the University of Georgia invites applications for a nine-month, tenure-track position in Medical Mycology at the rank of Associate or Full Professor, with an anticip...
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Pedro Beltrao @pedrobeltrao.bsky.social · 07/10/2026
Open AI released 722 manuscripts (skipping preprint server) on 372 families of math problems. On average it took their internal model a few hours each. Despite the scientific advance this must be a difficult day for the thousands (?) of people that were working on these. github.com/openai/math
github.com
GitHub - openai/math
Contribute to openai/math development by creating an account on GitHub.
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Micah @rincewind.run · 06/10/2026
remember after citizens united when everyone pretended super pacs wouldn't coordinate with politicians and would be truly independent entities? that was a fun five minutes
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Andres Bendesky @bendeskylab.com · 04/10/2026
10 days left to apply for an Assistant Professorship in Evolutionary Biology at Columbia.
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Chipockalips Now! @fragboner.bsky.social · 06/10/2026



right about now, the funk soul brother






check it out now, the funk soul brother






right about now, the funk soul brother






check it out now, the funk soul brother
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Geoff Brumfiel @gbrumfiel.bsky.social · 06/10/2026
The IceCube neutrino detector has won the 2026 Nobel Prize in physics. The Trump administration has proposed slashing its budget in half in 2027.
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Benjamin Freeman @benjaminfreeman.bsky.social · 06/10/2026
Come join the bio dept at Georgia Tech - we are hiring an ecologist! tinyurl.com/GT-eco-coasts
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