The CRUK CoL Centre PhD Programme Applications for the CRUK CoL Centre PhD programme starting in September 2027 are open This is a unique multidisciplinary and collaborative training opportunity for graduates with a background in biological, biomedical or other relevant sciences, who are interested in carrying out research in cancer biotherapeutics. Students

Segura-Bayona et al. uncover genetically separable ATRX functions that independently safeguard telomeres and genome replication, revealing how CST and 9-1-1 pathways suppress accumulation of toxic sin...

The ImageJ wiki is a community-edited knowledge base on topics relating to ImageJ, a public domain program for processing and analyzing scientific images, and its ecosystem of derivatives and variants...

The tRNA nuclease SLFN11 is epigenetically silenced in ~50% of treatment-naive tumours and is the strongest predictor of chemoresistance but why it is frequently inactivated in cancer is unknown. To a...

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...

Big pharma and investors are piling into the precision radiation space as the next generation of increasingly potent targeted α-particle therapies promises to destroy cancerous cells with minimum dama...

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James and Farnung identify three structural snapshots of CHD1-nucleosome complexes, visualizing conserved regulatory elements that explain how CHD1 binds nucleosomes, senses DNA, and controls remodeling directionality. Their work provides a mechanistic model for how chromatin remodelers couple nucleosomal substrate recognition to directional nucleosome sliding activity.

Genome alterations arise from inaccurate DNA repair, accumulating into distinct mutational signatures. Here, we investigate the role of every genomically encoded gene in double-strand break (DSB) repa...

High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...

The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.

Investigating the role of POLE3 in resistance to ionizing radiation treatment Primary supervisor: Roberto Bellelli, Queen Mary University of London Secondary supervisor: Graeme Hewitt, King’s College ...

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...