iiinova — where your digital self keeps evolving

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Cat Hicks @grimalkina.bsky.social · 15/02/2026

Key to efficient learning is realizing how we ACTUALLY learn, not just what FEELS like learning. I wrote a Claude Skill for some friends to help them think about this and they've liked it -- see Principles for some directions you could explore github.com/DrCatHicks/l...

github.com

GitHub - DrCatHicks/learning-opportunities: A Claude Code skill for deliberate skill development during AI-assisted coding

A Claude Code skill for deliberate skill development during AI-assisted coding - DrCatHicks/learning-opportunities

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Alex Naka @gottapatchemall.bsky.social · 15/01/2026

we're hiring! looking for a systems neuroscientist with extracellular ephys experience please share! link below, feel free to DM with questions

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Mark D Humphries @markdhumphries.bsky.social · 30/12/2025

Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...

medium.com

2025: A Review of the Year in Neuroscience

Enlightening the brain

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christine liu / two photon art @christineliu.art · 19/11/2025

Prima 2.2 companion device to restore vision for blindness caused by dry macular degeneration!! Created by @science.xyz !!!! Tera looks like a cartoon! Love it!!!!!! And optogenetics with ambient light by Amanda Tose and @gottapatchemall.bsky.social

Me Tera and Amanda together at Amanda’s poster

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Alex Naka @gottapatchemall.bsky.social · 01/10/2025

it's been seriously inspiring to watch the progress on this, E11 is kicking ass

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

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BejaLabTechnion @bejalab.bsky.social · 18/09/2025

I LOVE their curtain test!!

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Ofer Yizhar @oyiz.bsky.social · 18/09/2025

Really cool stuff! Engineered excitatory opsins responding to 15nW light

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Alex Naka @gottapatchemall.bsky.social · 18/09/2025

My group at Science has been running a big campaign to engineer new channelrhodopsins. Excited to share the first results from it today: a suite of highly sensitive new opsins. We call them "WAChRs". Everyday indoor office lighting is enough to activate them pretty strongly.

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Hideaki E. Kato @emekato.bsky.social · 18/09/2025

Happy to share our new preprint on the red-shifted channelrhodopsin ChR024, recently discovered by Inoue Lab (biorxiv.org/content/10.1... ), highlighting its long-wavelength absorption and ion conductance: biorxiv.org/content/10.1... Many thanks to our wonderful lab members and collaborators!

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mankrik's wife guy @byelacey.bsky.social · 24/06/2025

mac is here on this #makeaterriblecomicday2025 to school you all in THREAT MANAGEMENT SYSTEMS do not get caught off guard or Who Knows What Might Happen

a six panel comic titled "threat management: the complete guide". each panel is a hastily drawn white dog with large jowls detailing the steps on how to bark at things.

panel 1: step 1: scan all known dimensions. (the dog is staring into the middle distance, eyes seemingly going in different directions, while the background is reminiscent of the space odyssey stargate scene)

panel 2: lock in. (the dog's face is drawn in close up, biting his lip and growling)

panel 3: sound the alarm (the dog is barking, jowls flapping)

panel 4: cover the area in drool (the dog is spitting)

panel 5: refer to step 3 (the dog, head in the air, continues barking)

panel 6: ensure the people understand the urgency of the situation, then repeat step 3. (the dog is stomping, and huffing, looking toward the reader)

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womensartbluesky.bsky.social @womensartbluesky.bsky.social · 25/05/2025

Alexandra Buckle, contemporary printmaker known for her woodland scenes created via linocuts #WomensArt

Print featuring a lush green woodland scene with dappled bright sunlight and reflections on a stream to the right

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Brian Grubb @briancgrubb.bsky.social · 14/05/2025

not sure how i can be expected to focus on anything else today now that i've seen the promo photo from the Madden movie with Christian Bale as Al Davis and Nicolas Cage as John Madden

promo photo from the upcoming Madden movie with Christian Bale as Al Davis and Nicolas Cage as John Madden

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Alex Naka @gottapatchemall.bsky.social · 02/05/2025

Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies www.cell.com/cell/fulltex... broad spectrum antivenom

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Alex Naka @gottapatchemall.bsky.social · 01/05/2025

ATLAS: a rationally designed anterograde transsynaptic tracer www.nature.com/articles/s41... very cool

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 29/03/2025

Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations. Thanks @jjimenezluna.bsky.social for the help! 🌐 colab.research.google.com/github/sokry... 📄 www.biorxiv.org/content/10.1...

colab.research.google.com

Google Colab

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Lucien Hinderling @lhinderling.bsky.social · 23/02/2025

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...

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Ben Recht @beenwrekt.bsky.social · 18/02/2025

It’s easy to overfit if you try. How does machine learning practice get around it?

argmin.net

The Adaptivity Paradox

Test-set reuse: the problem that wasn't.

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Philip Gourevitch @pgourevitch.bsky.social · 15/02/2025

What these nihilistic vandals are doing to dismantle science & medicine—generations of expertise & public service & life improving benefits—is cultural revolution level national self harm. No foreign foe could inflict such brutal damage & senseless suffering on US so fast & effectively & unresisted.

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Josh Marshall @joshtpm.bsky.social · 14/02/2025

Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it. Strong power move for Team Cancer.

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Alex Naka @gottapatchemall.bsky.social · 23/01/2025

this is cool Rational multienzyme architecture design with iMARS

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Maximiliano José Nigro @maxnigro.bsky.social · 17/01/2025

Somatostatin interneurons have been an obsession of mine during my postdoc with Bernardo Rudy. They have diverse morphological, molecular and connectivity features. Here: a Martinotti with axon going all the way up, and a non-Martinotti whose axon targets layer 4. #neuroskyence

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Alex Naka @gottapatchemall.bsky.social · 19/12/2024

we're hiring a neuroscientist - looking for people with in vivo rodent physiology experience science.xyz/careers/neur...

science.xyz

Neuroscientist | Science Corporation

Science Corporation is a clinical-stage medical technology company.

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Jeremy Berg @jeremymberg.bsky.social · 16/12/2024

Bluetorial: Mentors III: The textbook author I worked in Lubert Stryer's laboratory as a freshman in college. This experience and my relationship with Lubert would change my life.

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 14/12/2024

Predicting absolute protein folding stability using generative models @mcagiada.bsky.social @sokrypton.org & I used ESM-IF to predict ∆G for folding & conformational change Paper, code and colab 📜 dx.doi.org/10.1002/pro.... 💾 github.com/KULL-Centre/... 👩‍💻 colab.research.google.com/github/KULL-...

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Alexander Terenin @avt.im · 15/11/2024

We've now got a project page for our NeurIPS paper "Cost-aware Bayesian Optimization via the Pandora's Box Gittins Index" - link below! This paper proposes a cost-aware acquisition function design principle for Bayesian optimization. Check it out! papers.avt.im/pandoras-box...

papers.avt.im

Cost-aware Bayesian Optimization via the Pandora's Box Gittins Index

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Andrew Payne @andrewcpayne.bsky.social · 03/12/2024

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

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Erik Ringen @err-ring.bsky.social · 18/11/2024

New blog post (and uh, new blog!) If you use observation-level random effects (e.g., for over-dispersed counts), your predictive checks are probably wrong. Here's how to do it the right way in both #brms and #PyMC. tl;dr: you need to sample new levels of the OLRE to avoid a false goodness-of-fit

erikringen.github.io

The right way to do predictive checks with observation-level random effects – Erik J. Ringen, PhD

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 03/12/2024

Three BioML starter packs now! Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc Pack 3: go.bsky.app/NAKYUok DM if you want to be included (or nominate people who should be!)

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Brian Naughton @btnaughton.bsky.social · 30/11/2024

New blogpost: The ABCs of Alphafold 3, Boltz and Chai-1 blog.booleanbiotech.com/alphafold3-b...

blog.booleanbiotech.com

Boolean Biotech

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Gabriele Corso @gcorso.bsky.social · 28/11/2024

We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...

github.com

GitHub - jwohlwend/boltz: Official repository for the Boltz-1 biomolecular interaction model

Official repository for the Boltz-1 biomolecular interaction model - jwohlwend/boltz

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 27/11/2024

Bacteriorhodopsin is a membrane-bound light-driven proton pump. Using neural networks, it's possible to redesign it so that it's soluble but retains its photocycle! @ivangushchin.bsky.social www.biorxiv.org/content/10.1...

Sequence design and initial characterisation of soluble BR variants

Photocycle and structure of soluble BR variant NeuroBR_A.

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Alex Naka @gottapatchemall.bsky.social · 26/11/2024

A muddy fall hike with Lily and puppy QWERTY From Nov 2022

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Diego del Alamo @delalamo.xyz · 25/11/2024

Yet more evidence that transfer learning of sequence-only PLMs does not benefit from scale beyond 650M params 🧵

Fig. 3. Impact of ESM Model size on transfer learning. LassoCV regression results using ESM mean embeddings for 35 DMS datasets. The x-axis represents different ESM model sizes: ESM1v 650M (orange) and ESM2 8M, 35M, 150M, 650M, 3B, and 15B (blues). The y-axis displays R^2 for each task.

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Kai Kupferschmidt @kakape.bsky.social · 24/11/2024

I think many people really underestimate how likely a new pandemic is to occur in the next four years. Even if you think of a pandemic as a once-in-a-century event, that's a 4% chance over the next four years. And I think in the world we live in a pandemic is far from a once-in-100 years event. 🧪

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emma zhou @emmz.bsky.social · 23/11/2024

so excited to finally announce this to the world! what’s a probe that can get anywhere in the brain, without destroying any tissue in the way, wiring up to existing structure to extract and inject information? sounds like a neuron :) #neuroscience #bci 🧪👩‍🔬🧠

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Max Hodak @maxhodak.bsky.social · 23/11/2024

I had an idea way back in college which I've long thought could be, in many ways, the ultimate BCI technology. What if instead of using electrodes, we used biological neurons embedded in electronics to communicate with the brain? Enter biohybrid neural interfaces: science.xyz/news/biohybr...

science.xyz

Biohybrid neural interfaces: an old idea enabling a completely new space of possibilities | Science Corporation

Science Corporation is a clinical-stage medical technology company.

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 18/11/2024

Two BioML starter packs now: Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc DM if you want to be included (or nominate people who should be!)

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Ashley Juavinett, PhD @ashleyjuavinett.bsky.social · 20/11/2024

dear cornell I AM HERE see you tomorrow

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Nicola Grissom @nicolagrissom.bsky.social · 19/11/2024

Hello numerous people who joined and followed! I want to hear your neuroscience takes, but not the same old debates. There's so much we can discuss that's truly new. Here I'll start: -The brain: too big, or not big enough -Most overrated region of cortex -manifolds: isn't just one fold sufficient

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 19/11/2024

Pack 2 is now up to 90/150. Get in while I can still keep up!

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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 19/11/2024

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...

Nature paper article with title and abstract

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Armin Ronacher @mitsuhiko.at · 19/11/2024

This is clever. Because uv supports explicit indexes you can in fact switch pytorch versions based on environment markers. docs.astral.sh/uv/guides/in...

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