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Matteo Cagiada

@mcagiada.bsky.social
234 followers 177 following 13 posts

🇮🇹, Computational biophysicist, NNF Postdoc in #OPIG at University of Oxford | previously PhD and PostDoc at University of Copenhagen (KLL group)

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Matteo Cagiada @mcagiada.bsky.social · 12/11/2025
My first full contribution from my time in @opig.stats.ox.ac.uk is now out! Together with @fspoendlin.bsky.social (and with contributions from King Ifashe), we created FlAbDab and FTCRDab: two large-scale, open molecular dynamics datasets to study flexibility in immune receptors.
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Stephanie Wankowicz @stephanieaw.bsky.social · 16/05/2025
The third episode of The Tortured Proteins Department is out now! We chatted about grant cancellations, exciting regional meetings and reunions, two fun new preprints, community norms around code release, and the importance of giving kudos. @fraserlab.com
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 15/05/2025
Led by @vvouts.bsky.social in @rhp-lab.bsky.social, we measured the degron potency of >200,000 30-residue tiles from >5,000 cytosolic human proteins and trained an ML model for degrons 📜 www.biorxiv.org/content/10.1... 🖥️ github.com/KULL-Centre/...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 04/05/2025
While this paper looks interesting, let me just say (again) that (essentially all) NMR ensembles in the PDB are NOT thermodynamic ensembles or meant to represent these. They are "uncertainty ensembles" and using them to benchmark machine learning (or other) models of dynamics is not a good idea.
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Nele Quast @nele-q.bsky.social · 01/05/2025
Do you wish working with T-cell receptor structures was easier? Us too! STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available! Github: github.com/npqst/stcrpy/ Pre-print: www.biorxiv.org/content/10.1... 1/3
github.com
GitHub - npqst/STCRpy
Contribute to npqst/STCRpy development by creating an account on GitHub.
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Fergus Imrie @fergusimrie.bsky.social · 23/04/2025
3-year postdoc opportunity as part of the Novo Nordisk - Oxford Fellowship programme! Develop machine learning approaches for drug discovery with me, Charlotte Deane (Oxford), and Christos Nicolaou (Novo Nordisk). 1 week left to apply! Details in next post
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Matteo Cagiada @mcagiada.bsky.social · 18/04/2025
Backbone predictions are great - but what about side chains? Me and @emilthomasen.bsky.social are happy to present AF2χ, a tool for predicting side-chain heterogeneity in protein structures!. If you want to read more about it, check out our preprint and localColabFold implementation!
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 17/04/2025
AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...
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Brotman Baty Institute @brotmanbaty.bsky.social · 27/03/2025
Mark your calendars now. The next variant effects seminar is Monday, 1 April, 9 am (Pacific), featuring Joyce Kang @harvard.edu @broadinstitute.org & Yiyun Rao @pennstateuniv.bsky.social. @varianteffect.bsky.social Learn more: www.varianteffect.org/seminar-series
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Matteo Cagiada @mcagiada.bsky.social · 27/03/2025
Delighted to announce that our paper "Predicting absolute protein folding stability using generative models"(lnkd.in/dZJMiY4r) has been awarded the Protein Science BEST PAPER 2024 by @proteinsociety.bsky.social.
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Matteo Cagiada @mcagiada.bsky.social · 24/01/2025
I am happy to share our latest review, which discusses the challenges of predicting unbound antibody structures using deep learning. Special thanks to Alexander Greenshields-Watson for leading and coordinating this work! 🧬💻 doi.org/10.1016/j.sb... #AntibodyEngineering #DeepLearning
doi.org
Redirecting
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Oxford Protein Informatics Group (OPIG) @opig.stats.ox.ac.uk · 15/01/2025
OPIG is now on Bluesky! Follow us for updates about the group's latest work, web app updates, and more. opig.stats.ox.ac.uk
opig.stats.ox.ac.uk
OPIG
Oxford Protein Informatics Group
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 14/12/2024
Predicting absolute protein folding stability using generative models @mcagiada.bsky.social @sokrypton.org & I used ESM-IF to predict ∆G for folding & conformational change Paper, code and colab 📜 dx.doi.org/10.1002/pro.... 💾 github.com/KULL-Centre/... 👩‍💻 colab.research.google.com/github/KULL-...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 16/03/2024
New preprint with @mcagiada.bsky.social & @sokrypton.org in which we present a benchmark and predictions of absolute protein stability (ΔG not ΔΔG) using using likelihoods from a generative model, and also benchmark it for conformational free energies against NMR 🧬 🧶 doi.org/10.1101/2024...
Scatter plot with experimental and predicted stabilities
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 24/10/2023
I'm excited to present Francesco Pesce's work on developing, applying & experimental testing of a method to design intrinsically disordered proteins. Our algorithm combines MC sampling in sequence space with an efficient CG simulation model and alchemical free-energy calculations. 🍝 🧶🧬
Schematic outline of a design algorithm for intrinsically disordered proteins
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