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Gerry Tonkin-Hill

@gerrythill.bsky.social
946 followers 561 following 20 posts

Group leader at Peter Mac & the Doherty Institute in Melbourne, Australia microbial genomics, statistics, machine learning

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Reposted by Gerry Tonkin-Hill
Jim Shaw @jimshaw.bsky.social · 15/09/2026
The sylph metagenome profiler is v1.0.0! sylph-docs.github.io A new DB format + approach --> huge performance gains: GTDB-R232 (200k species) now takes < 5 GB of RAM and ~30s (2GB fq.gz). Huge thanks to @benjwoodcroft.bsky.social and his ongoing performance efforts (github.com/wwood/weebill)
sylph-docs.github.io
Documentation for sylph - ultrafast, precise metagenomic profiling
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Wellcome Sanger Institute @sangerinstitute.bsky.social · 14/09/2026
New research suggests that the risk of developing bacterial pneumonia, sepsis, and meningitis after air pollution exposure could depend on the subtype of bacteria a person has. Read the full story ⤵️
sanger.ac.uk
Bacteria in airway shape air pollution health risk
By studying over 59,000 cases of invasive disease caused by Streptococcus pneumoniae, experts have found that the subtype of bacteria influences the impact of environmental factors, such as air pollution, on disease risk.
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Inigo Martincorena @imartincorena.bsky.social · 03/09/2026
Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and @r-rahbari.bsky.social. www.biorxiv.org/content/10.6...
biorxiv.org
A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells
Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...
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Gerry Tonkin-Hill @gerrythill.bsky.social · 02/09/2026
Glad to share StrainSpy, a new method developed by Sudaraka and co which identifies strain-level associations in metagenomics using ANI estimates from tools like Sylph. www.biorxiv.org/content/10.6...
biorxiv.org
Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy
Genetic variation among microbial strains of the same species can profoundly influence their phenotypes, ecological functions, and impacts on human health. Traditionally, the relative abundance of a s...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 02/08/2026
Exciting collaboration with @annabiosys.bsky.social's lab just went online. @isbscience.org metaSPLiT: a fast, efficient, and relatively low-cost method for single-cell transcriptomics in the human gut microbiome. 👇
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Sonika Tyagi @tsonika.bsky.social · 31/07/2026
We are hosting the 2026 @abacbs.bsky.social conference at RMIT University City Campus Melbourne on 16-20 Nov 2026. Hope to see you there.
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Josie Bryant @josiebryant.bsky.social · 08/07/2026
Very proud of this preprint out of my lab, our first (of hopefully many) host-microbe spatial transcriptomics paper. www.biorxiv.org/content/10.6... Amazing insights into P. aeruginosa biology and chronic airway disease @cysticfibrosis.org.uk @sangerinstitute.bsky.social @asthmaandlung.org.uk
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Ryan Wick @rrwick.bsky.social · 24/07/2026
New blog post! I reran the Autocycler paper benchmarks on some new tools/versions/pipelines: rrwick.github.io/2026/07/24/b... (1/3)
rrwick.github.io
Benchmark update: Ilesta, Autocycler-fast and new versions
a blog for miscellaneous bioinformatics stuff
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César de la Fuente @delafuentelab.bsky.social · 20/07/2026
Biology has plenty of data—the challenge is making it usable. AllTheBacteria transforms 2.44 million public bacterial and archaeal genomes into an open, uniformly processed, searchable, AI-ready resource. www.biorxiv.org/content/10.1...
biorxiv.org
AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics
Public microbial genomes encode an immense record of biological diversity, evolution and molecular function, but much of this information remains difficult to reuse because raw sequencing data are not...
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Reposted by Gerry Tonkin-Hill
Kate Baker @ksbakes.bsky.social · 09/07/2026
👀👇 New work on sexually transmitting Shigella (press-friendly: bit.ly/4bBarEL) From continued collaboration with @clairejenkins2.bsky.social @ukhsa.bsky.social, @pducambridge.bsky.social co-lead @hsalje.bsky.social, a talented student Julia Marshall www.linkedin.com/in/julia--ma..., and others! 🧫🧬💊
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Gerry Tonkin-Hill @gerrythill.bsky.social · 30/06/2026
Happy to share the latest work from Zunair Khurram, a PhD student in our lab! Zunair has developed a new method, MxSure, to infer within-host substitution rates and transmission thresholds from longitudinal isolate and metagenomic sequencing data. www.biorxiv.org/content/10.6...
biorxiv.org
MxSure: a mixture model for inferring within-host substitution rates and transmission SNP thresholds
Quantifying short-term evolutionary rates of microbial genomes is essential for understanding the processes that shape within-host evolution and for establishing thresholds needed to track transmissio...
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Michael Payne @mjohnpayne.bsky.social · 26/05/2026
Finally a preprint for our tool DAMPA (Australiana included) that generates efficient probe panels for targeted metagenomics from pangenome graphs. Presented at ABPHM and ABACBS last year. www.medrxiv.org/content/10.6...
medrxiv.org
DAMPA - accelerated and simplified design of probe panels for targeted metagenomics using pangenome graphs
Targeted metagenomics, where samples are enriched for multiple organisms of interest using oligonucleotide probes, is a highly efficient sequencing methodology that is becoming standard practice for g...
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Reposted by Gerry Tonkin-Hill
Vijini Mallawaarachchi @vijinim.bsky.social · 08/05/2026
🎉 Excited to share that our paper, “agtools: A Software Framework to Manipulate Assembly Graphs”, has been accepted in Bioinformatics Advances. (1/n) 🔗 GitHub: github.com/Vini2/agtools 📄 Paper: academic.oup.com/bioinformati... #bioinformatics #genomics #openscience
academic.oup.com
agtools: A Software Framework to Manipulate Assembly Graphs
AbstractMotivation. Assembly graphs are a fundamental data structure used by genome and metagenome assemblers to represent sequences and their overlap info
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John Lees @johnlees.bacpop.org · 06/05/2026
New work on using transformers (using gene order) for tasks in genomic epidemiology: www.biorxiv.org/content/10.6... We trained BART models (w/ extended context windows) on E.coli and S.pneumo from AllTheBacteria and tested if the model could find new strains, insertions (blaCTX-M) and co-selection
Embeddings of gene order from PanBART model
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Sam Horsfield @samuelhorsfield.bsky.social · 13/04/2026
ggCallaroo v0.1.0 is now out! This snakemake pipeline predicts, clusters and annotates bacterial genes using ggCaller, Panaroo and Bakta. It generates Panaroo files with functional annotations already integrated, which can then be used with the usual downstream tools. github.com/samhorsfield...
github.com
GitHub - samhorsfield96/ggCallaroo: A snakelike pipeline combining ggCaller and Panaroo.
A snakelike pipeline combining ggCaller and Panaroo. - samhorsfield96/ggCallaroo
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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 06/04/2026
We’re hiring! Postdoc position at APC/School of Micro, working on gut microbiome–pathogen interactions in an ERC-funded project with @hilarybrowne.bsky.social 🧫 Anaerobic microbiology + bioinformatics 📅 Deadline: 17 April 2026 📰 Apply here: buff.ly/IxGKwH6 #Microbiome #Postdoc #AcademicJobs
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes. www.biorxiv.org/content/10.6...
biorxiv.org
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Rebecca A. Gladstone @becctococcus.bsky.social · 25/03/2026
Now published! 'Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli' www.nature.com/articles/s41... insights below.....
nature.com
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John Lees @johnlees.bacpop.org · 17/03/2026
You can now view a tree of 2,399,238 bacterial genomes we made from AllTheBacteria (on the great Taxonium): taxonium.org/atb That's a big tree! (unless you're used to SC2 trees)
taxonium.org
Taxonium
Interactive exploration of large phylogenetic trees
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Zamin Iqbal @zaminiqbal.bsky.social · 25/02/2026
@wytamma.bsky.social 's WASM tools have transformed my experience of teaching Python to first year undergraduate biologists this year. Since last year, I've been teaching ~400 undergrads how to code (functions, lists, dictionaries, loops) over (one hour intro lecture +) two 2-hour practicals. 1/n
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Gerry Tonkin-Hill @gerrythill.bsky.social · 20/02/2026
It's a bit last minute, but we have an RA/junior postdoc position available in my lab (closing Sunday). Please reach out if you're interested in developing and applying methods to analyse microbial genomes and metagenomes! careers.petermac.org/job/MELBOURN...
careers.petermac.org
Research Assistant - Tonkin-Hill Lab
Research Assistant - Tonkin-Hill Lab
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Reposted by Gerry Tonkin-Hill
Sam Horsfield @samuelhorsfield.bsky.social · 07/02/2026
At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...
biorxiv.org
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Tami Lieberman @contaminatedsci.bsky.social · 05/01/2026
Proud to announce SimPhyNI, a new tool for bacterial GWAS with higher precision and scalability than existing tools. Try it out and let us know what you think!!
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Reposted by Gerry Tonkin-Hill
Ben Vezina @bananabenana.bsky.social · 13/12/2025
Absolutely stoked to have this published in @plosbiology.org We looked at the metabolism of #Klebsiella pneumoniae 🦠🧫. We not only demonstrated lineage-specific #metabolism, but that lineages can cross-feed and support each other. journals.plos.org/plosbiology/... #MicroSky #microbiology 🧬 🧪 💊
journals.plos.org
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation
Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...
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Rob Edwards @linsalrob.bsky.social · 26/11/2025
Long read Metagenomics, #phage and #prophage in the gut by Ami Bhatt's group. Beautiful data showing changes in phages over two years #phagesky www.nature.com/articles/s41...
nature.com
Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature
Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...
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Vijini Mallawaarachchi @vijinim.bsky.social · 25/11/2025
🧬 Come check out my poster on agtools, an open-source Python framework for analysing and manipulating assembly graphs at #ABACBS2025 Poster #106 • 💻 Github: github.com/Vini2/agtools 📄 Preprint: biorxiv.org/content/10.110…
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Alicia Oshlack @aliciao.bsky.social · 26/11/2025
PeterMac @petermaccc.bsky.social representing at #abacbs2025 What a community 😍
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David Ma @frostickle.bsky.social · 25/11/2025
Great talk from Michael Payne at #ABACBS2025 on DAMPA - tool for designing probe panels for targeted metagenomics using pangenome graphs! Captures all diversity efficiently, uses fewer probes than competitors. Critical for syndromic surveillance! 🧬🔬 #Metagenomics
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John Lees @johnlees.bacpop.org · 19/11/2025
Happy to share our new AMR resource which has phenotypic AMR (usually MIC data) collected from publications and databases. This is paired with assemblies and annotations We're excited for users who might train new models, find phenotype/genotype mismatches, or any other use
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 13/11/2025
📣 Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems". co-director - @flash-point.bsky.social 🦠💥 It's free, & we have an amazing line-up of speakers! Dec. 12th. Please share! isbscience.org/2025-isb-vir...
isbscience.org
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects
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Samuel Aroney @aroneys.bsky.social · 13/11/2025
“Bin Chicken” is now published in Nature Methods! It substantially improves genome recovery through rational coassembly 🧬🖥️. Applied to public 🌍 metagenomes, we recovered 24,000 novel species 🦠, including 6 new phyla. doi.org/10.1038/s415... @benjwoodcroft.bsky.social @rhysnewell.bsky.social 🧵1/6
Logo of Bin Chicken (Australian white ibis) on a rubbish bin, pulling out a strand of DNA
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Michael Kuhn @biocs.bsky.social · 15/08/2025
We're very happy to release our new database Metalog metalog.embl.de ! It offers manually curated and harmonised contextual data for 110k metagenomics samples across the globe, incl. precomputed taxonomic profiles, for interactive browsing and for download 🧵 1/7 #microsky
metalog.embl.de
Metalog
Metalog is a repository of manually annotated metadata (or contextual data) for metagenomic sequencing data from across the globe.
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Ryan Wick @rrwick.bsky.social · 29/09/2025
Happy to share that the paper describing Autocycler is now 100% up: doi.org/10.1093/bioi... (1/3)
doi.org
Autocycler: long-read consensus assembly for bacterial genomes
AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l
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Zamin Iqbal @zaminiqbal.bsky.social · 25/09/2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n
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Ruoshi @ruoshiz.bsky.social · 16/09/2025
Happy to see that Spacedust is now published on Nature Methods! It combines sensitive Foldseek structure search and conserved neighborhood detection to discover functionally-associated gene clusters in prokaryotic & viral genomes. 1/6🧵
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Zamin Iqbal @zaminiqbal.bsky.social · 10/09/2025
Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...
nature.com
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.
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Nikolai Slavov @slavov-n.bsky.social · 10/09/2025
Large AI models are reported to achieve high accuracy (AUROC) predicting pathogenic variants across the genome. A preprint reports that the predictions are based on splice variants. Using only this info (no sequences, no AI) achieves AUROC=0.944 across noncoding variants. 1/2
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Rayan Chikhi @rayanchikhi.bsky.social · 03/09/2025
🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...
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Michael Baym @baym.lol · 01/09/2025
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen: www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics
Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...
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Rob Edwards @linsalrob.bsky.social · 17/07/2025
The 10th anniversary #ABACBS conference will be held in Adelaide from Nov 24-28. If you're thinking of coming, get in quick, as it's going to be a big week: A fantastic #bioinformatics conference with outstanding national and international speakers, and we're wrapping up the ABACBS week an AC/DC gig
The view of the Adelaide Oval, site of the 2025 Australian Biology and Computational Biology Society (ABACBS) conference, from across the River Torrens. The conference will be held in Adelaide from 24 to 28 November and celebrates 10 years of ABACBS.
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Ben J Woodcroft @benjwoodcroft.bsky.social · 16/07/2025
Out in @natbiotech.nature.com: Metagenome taxonomy profilers usually ignore unknown species. SingleM is an accurate profiler which doesn't, even detecting phyla with no MAGs. Profiles of 700,000 metagenomes at sandpiper.qut.edu.au. A 🧵
Logo for the Sandpiper website
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abacbs.bsky.social @abacbs.bsky.social · 04/07/2025
The day is finally here! 🎉 We’re releasing the invited speaker line-up, key dates, and lots more info for ABACBS 2025. Check it out and share widely: www.abacbs.org/abacbs2025 Registrations and abstract submissions open next week, with abstracts due in August!
abacbs.org
ABACBS 2025 Conference
Adelaide, South Australia. Nov. 24-
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Jesse Shapiro @bjesseshapiro.bsky.social · 11/06/2025
Are you a recent PhD (or soon to be PhD) from outside Canada looking to do a postdoc in Quebec? Get in touch if you are excited about microbes, evolution, ecology, genomics (or all of the above!) and I'd be happy to help develop a project together! www.mcgill.ca/gps/funding/...
mcgill.ca
PBEEE/Quebec Merit Scholarship for Foreign Postdocs and Visiting Research Student and Visiting Researchers
**Note that the FRQ is in the process of revamping their webpages. We will update links soon as we can with the current 2025 year's information. Be sure to check back to see if any eligibility or docu...
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Ed Feil @edfeil.bsky.social · 20/05/2025
www.bath.ac.uk/jobs/Vacancy... Post doc available to work on Candida genomics with me at the Milner Centre for Evolution (U Bath, UK) as part of the JPIAMR funded project Fugaci www.jpiamr.eu/projects/fug... For queries, email me!
jpiamr.eu
FuGACI – JPIAMR
JPIAMR is a global collaborative organisation and platform, engaging 28 nations to curb antimicrobial resistance (AMR) with a One Health approach.
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Feargal Ryan @feargalr.bsky.social · 03/04/2025
Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology www.nature.com/articles/s41...
nature.com
Bifidobacteria support optimal infant vaccine responses - Nature
Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...
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Rebecca A. Gladstone @becctococcus.bsky.social · 03/04/2025
Being able to data plasmid acquisition, and to see the diversity of plasmids being gained and lost from lineages, was really eye opening! It was a pleasure to contribute my tiny bit to this huge paper and the data has so much more to give! @arredondo.bsky.social @gerrythill.bsky.social et al.
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Ben Hogan @benjhogan.bsky.social · 05/03/2025
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in Melbourne, Australia 🔬🦘💥 Work in a cutting edge research environment in a vibrant world city! We value research excellence, creativity and diversity. Join us! careers.petermac.org/job/MELBOURN...
careers.petermac.org
Group Leader
Group Leader
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Lars Barquist @lbarquist.bsky.social · 17/01/2025
Interested in predicting AMR in bacteria? We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. With @nwheeler443.bsky.social and former PhD student Yanying Yu. 🦠🧫🧬🖥️🧪 www.biorxiv.org/content/10.1...
biorxiv.org
Biased sampling confounds machine learning prediction of antimicrobial resistance
Antimicrobial resistance (AMR) poses a growing threat to human health. Increasingly, genome sequencing is being applied for the surveillance of bacterial pathogens, producing a wealth of data to train...
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Ryan Wick @rrwick.bsky.social · 31/12/2024
New year, new assemblies! I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes! It's the successor to Trycycler, designed to be faster and less reliant on user intervention. Check it out: github.com/rrwick/Autoc... (1/5)
github.com
Home
A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler
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Martin Hunt @martibartfast.bsky.social · 29/11/2024
I just made a first release of TNA - new tool to compare 2 bacterial genomes. Is shamelessly inspired by ACT, but should be simpler to use. Drag-n-drop two genomes: it runs BLAST for you and then you can visualize. For Mac, Windows 11, Linux tna.readthedocs.io
tna.readthedocs.io
TNA documentation — TNA 0.0.1 documentation
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